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The extracellular matrix supports breast cancer cell growth under amino acid starvation by promoting tyrosine catabolism

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2 institutional releases

Published in PLOS Biology · View the paper (DOI)

Breast cancer cells survive by consuming the extracellular matrix when nutrients are scarce. The process involves macropinocytosis and metabolic conversion of key amino acids to energy-releasing substrates. This mechanism could represent a novel therapeutic target.

Coverage from 2 institutions

  • Energy-starved breast cancer cells consume their surroundings for fuel
    • Article 1 PLOS · Jan 16, 2024 · first to report
    • Article 2 University of Sheffield · Jan 16, 2024