Published in Nature · View the paper (DOI)
Scientists analyzed somatic mutations in stomach lining tissue to explore cancer development, finding that cells with 'driver' mutations occupy almost 10% of the gastric lining by age 60. An unusual discovery suggests exposure to an unknown mutagen led to trisomy of chromosomes 13, 18 and 20, increasing the risk of gastric cancer.
Coverage from 2 institutions
- Earliest stages and possible new cause of stomach cancer revealed Wellcome Trust Sanger Institute · Mar 19, 2025 · first to report
- HKUMed uncovers early mutations and risk factors for stomach cancer, and develops a pre-cancer model for stomach cancer prevention The University of Hong Kong · Apr 16, 2025