Articles tagged with Bioreactors
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Scientists at Southwest Research Institute (SwRI) have successfully replicated induced Pluripotent Stem Cells (iPSCs) using a new application of their cell-expansion bioreactor. The bioreactor's unique geometry allows for the growth of large quantities of iPSCs, which can differentiate into any other cell type in the body.
Researchers developed a technology to detach cells from surfaces on demand, reducing waste and improving workflow in industrial processes. The system uses electrochemically generated bubbles to separate cells without damaging them, paving the way for more efficient CO2 absorption and lifesaving cell therapies.
The EBDM system effectively controls membrane fouling, enhances effluent quality, and improves methane productivity in wastewater treatment. The electric field modifies the physicochemical properties of the biomass, reducing the fouling potential and promoting microbial metabolism.
Researchers have developed a bioreactor that can produce over 10 grams of chicken muscle for cultured meat applications. The system enables cell distribution, alignment, contractility, and improved food-related properties, making it a practical alternative to vascular-based methods.
Researchers have developed a new technique for quantum sensing using nanodiamonds in microdroplets, which can detect trace amounts of certain ions and molecules. This method uses flowing droplets and carefully modulated microwaves to ignore unwanted background noise and add precision.
A team of Kobe University bioengineers successfully produced artepillin C in bioengineered yeast, achieving ten times the previous yield. The production process involved carefully tuning key steps along the molecular production line, and further improvements are being explored to increase efficiency.
Researchers developed a system using woodchips and biochar to remove nitrogen, phosphorus, and pharmaceuticals from wastewater. The treatment-train approach showed significant removal of pollutants, with the biochar acting like activated carbon to efficiently remove pharmaceutical residues.
Researchers on the International Space Station have developed human liver tissues with enhanced functionality in microgravity, paving the way for novel stem cell-derived liver tissues and alternative to traditional liver transplants. The team also created a bioreactor system for stable supercooling preservation of tissues.
A novel genus, Candidatus Alkanivoras nitrosoreducens, is described as potentially performing nitrite-driven anaerobic ethane oxidation. The study reveals a prospective fumarate addition pathway for anaerobic ethane oxidation and a complete denitrification pathway for nitrite reduction.
Researchers establish new standards for laboratory experiments to improve PET recycling efficiency. Four engineered enzymes were tested, with LCC-ICCG outperforming the others in terms of depolymerisation rate and enzyme requirement. The study aims to accelerate the development of industrial-scale solutions for PET waste management.
A new tool has been developed to rapidly grow cancer-killing white blood cells, called T cells, which could advance the availability of immunotherapy. The bioreactor is 30% faster than current technologies and can be self-contained in a sterile cabinet.
Scientists at UCSF have developed an artificial kidney that can mimic key functions of a real kidney. The bioreactor keeps kidney cells alive for up to seven days and has shown promising results in animal trials. If successful, the device could improve treatment for kidney disease, making it more effective, tolerable, and comfortable.
The Texas Heart Institute has received a five-year, $2 million grant from the National Institutes of Health to advance organ bioengineering. The project aims to develop transplantable bioartificial hearts to combat end-stage heart failure.
Researchers discovered a methanogen that converts sulfate into a cellular building block, reassembling a metabolic pathway piece by piece. The microbe assembled the first sulfate assimilation pathway from a methanogen, using genetic tricks to overcome energetic costs and toxic intermediates.
Researchers developed a technology to prevent algae buildup on photobioreactor surfaces, allowing for more efficient CO2 capture. The system uses electrostatic repulsion created by coating the container with an electrically charged material and applying a small voltage.
A new bioreactor system developed by KAUST scientists delivers gases to maintain physiological environments, reducing unpredictable shifts in cell growth. The system allows for more accurate and reproducible experiments in biomedical research.
A two-year research project aims to overcome technical difficulties in large-scale algae cultivation, a promising method for climate change mitigation. The ROBA project focuses on developing economically feasible algal cultivation processes using advanced measurement technologies and bioprocess engineering.
Researchers at NUS have developed a method to produce cell-based meat using magnetic pulses, reducing reliance on animal products and increasing efficiency. This technology has the potential to revolutionize the food industry and improve regenerative medicine by stimulating the growth of healthy cells.
Researchers at KAUST developed conductive membranes that stimulate microbial growth and separate biochemical products, reducing the CO2 conversion time from over 30 days to just one month. The membranes use nickel nanoparticles to catalyze hydrogen production, enhancing efficiency and stability in microbial electrosynthesis systems.
Researchers have developed a unique 3D printed system to harvest mesenchymal stem cells from bioreactors, which can be used for various treatments. The system combines microfluidics and 3D printing to process adult stem cells, potentially making stem cell therapies more widely available.
A UFZ research team has developed a new method called 'mass transfer with a loop' to stabilize microbial communities in bioreactors. This approach prevents the loss of crucial microorganisms, which are essential for various biotechnological processes, by synchronizing their composition and functions.
Researchers have identified efficient technologies to remove endocrine disruptors from wastewater, including ozonation and adsorption with activated carbon. These methods can be added to existing treatment plants, improving performance without major changes.
A study of 20 full-scale WWTPs found MBR performed better than CAS in terms of energy consumption and environmental benefits, with increased marginal environmental benefit and average net profit. The techno-economic feasibility of retrofitting from CAS to MBR is confirmed, especially under strict effluent standards.
Researchers have designed and built bioreactors at a fraction of the cost of commercial systems to investigate bacterial biofuel production. A subtle change to a single gene can result in remarkable changes to how sugars are converted to biofuel products, revealing new avenues for improving biofuel production.
Researchers at the University of Helsinki and VTT Technical Research Centre of Finland have developed a biotechnology-based solution to produce ovalbumin, a key protein in egg white powder. The fungus-produced ovalbumin reduces greenhouse gas emissions and land use by up to 72% compared to traditional chicken-based production.
A team of researchers has developed a Dynamic Sampling Platform to analyze cells in real-time, overcoming the time-consuming and expensive process of biomanufacturing. The platform provides insight into cell behavior and biochemical information needed for process control, potentially lowering the cost of cell therapies.
Researchers at RMIT University have developed a new bioreactor technology to create artificial super stool for treating chronic gut infections. The innovation aims to overcome the limitations of donor-derived faecal microbiota transplantation (FMT), an established life-saving therapy.
The project will populate a database of bioreactor and saturated buffer designs, trial novel modifications to improve efficiency, and install monitoring systems for real-time water quality detection. The goal is to increase adoption and effectiveness of these low-cost solutions in the Midwest.
Researchers at UCSF have successfully implanted a bioreactor containing human kidney cells into pigs without triggering an immune reaction or blood clots. The device, similar to the size of a deck of cards, maintained healthy kidney function and demonstrated progress towards eliminating dialysis for patients with end-stage renal disease.
The Southwest Research Institute (SwRI) has received additional funding to develop a novel bioreactor for stem cell and CAR T-cell manufacturing, which could revolutionize personalized regenerative medicine.
Researchers reconstructed jawbones in sheep using 3D printed bioreactors filled with autologous bone or synthetic graft. The bioreactors aided the growth and harvesting of bony tissue, successfully repairing five out of six sheep's jawbones.
A team of scientists designed a bioreactor device that induces partial hindlimb regeneration in adult frogs by stimulating tissue repair at the amputation site. The device triggers complex downstream outcomes, resulting in bigger, more structured appendages.
Researchers developed a microfluidic technique to monitor specific biomolecules, indicating the health of living cell cultures. The technique uses electrospray ionization mass spectrometry and can detect low concentrations of biomolecules, guiding process control and improving quality control in cell manufacturing.
A Kyoto University study reveals that turbulence enhances platelet generation in the blood, potentially resolving global shortages of these cells. The discovery could enable mass production of platelets using iPS cell technology.
Researchers at TU Wien have created a comprehensive mathematical model that accurately replicates the complex growth behavior of penicillin-producing organisms. This model is now helping Sandoz GmbH to optimize its production process, ensuring optimum quality by adjusting parameters such as nutrient supply in real-time.
By applying analytical techniques for stirred bioreactors to orbitally shaken bioreactors, researchers reconstructed a 3D model of OSB flow and identified key features of coherent structures. The study assesses the dispersion of nutrients in OSBs using Finite-Time Lyapunov Exponent analysis.
Researchers discovered that Chlamydomonas algae can control its adhesion to surfaces using blue light, a phenomenon that could improve the efficiency of biofuels production. By understanding this mechanism, scientists hope to develop algae strains with modified photoreceptors that don't form biofilms on glass walls.
Researchers discovered that microgravity inhibits cartilage formation, while cyclic hydrostatic pressure increases cartilage production. This finding has significant implications for regenerating cartilage in space travelers and patients on prolonged bed rest or paralyzed due to trauma.
Penn State researchers have developed a novel approach to efficiently convert potato waste into ethanol, achieving a maximum ethanol concentration of 37.93 grams per liter in a co-culture biofilm reactor. The process eliminates the need for externally added enzymes and energy costs, reducing production costs and increasing productivity.
Researchers at UBC Okanagan have developed a new biomass pretreatment technique that significantly reduces production time for biofuels, making them safer and more efficient. The new method can produce methane 172 per cent faster than traditional processes using forestry waste products like Douglas fir bark.
Researchers are using bioreactors to intercept nitrogen-rich drainage water from tile-drained fields, neutralizing the nutrient that causes problems for aquatic ecosystems. The trenches enhance a natural process, converting nitrogen into benign gas, and have shown promise in improving water quality.
Columbia University researchers develop groundbreaking technique to repair large bone defects in the head and face with lab-grown living bone. The innovative approach, which uses autologous stem cells derived from a patient's fat, enables precise anatomical replication and active bone remodeling.
Researchers designed a biomimetic environment to support the growth of engineered whole lungs. The new bioreactor system mimics ventilation and blood flow in the chest cavity, keeping lung tissue alive and functional.
Bioreactors are passive filtration systems that remove up to 45% of nitrate from water draining from farm fields. Researchers are urging large-scale deployment to address the 'dead zone' issue in the Gulf of Mexico.
A cell-free protein synthesis system developed at Oak Ridge National Laboratory uses microfabricated bioreactors to produce therapeutic proteins for medicines and biopharmaceuticals. This technology simplifies the process, lowers cost, and enables point-of-care use.
Researchers found that wetlands created between tile-drained agricultural fields and rivers can remove 62% of nitrates from water. The slow flow of water through the wetland allows microbes to eliminate nitrate, reducing its emission as a greenhouse gas. Building a wetland is an effective long-term solution for reducing nitrate runoff.
Researchers developed a scalable, next-generation platelet bioreactor to generate fully functional human platelets in vitro. The breakthrough addresses blood transfusion needs and has several advantages over conventional donor-derived platelets.
Michigan State University scientists develop a standardized algae growing platform that simulates dynamic natural environments to cultivate strains capable of producing oil in real-world settings. The ePBR system has inspired the launch of a spinoff company and shows promise for scalable algae biofuel production.
Researchers at NIST created a novel bioreactor that stimulates and evaluates tissue as it grows using ultrasound technology, reducing the need for destructive sampling. The device has shown promise in creating three-dimensional engineered cartilage with improved structural properties.
Scientists at Ben-Gurion University have created bioreactors that increase microalgae biomass yields dramatically. The innovative design, which synchronizes photosynthesis with flow patterns and illumination, has the potential to make microalgae an economically viable source of renewable energy.
A new study optimizes fluid mixing in bioreactors by controlling undercurrents to improve cell exposure. Researchers found that rotating inner cylinders and adjusting fluid velocities can create homogeneous feeding of cells from a liquid nutrient supply.
Researchers at Texas A&M University have developed a way to control the formation and dispersal of biofilms by manipulating bacterial signals. This breakthrough enables the creation of novel bioreactors that can efficiently produce chemicals and potentially transform the economy.
Researchers used state-of-the-art instrumentation to track wave motion and measure liquid velocity, discovering that orbital shaking enhances mixing near the glass wall. The study suggests optimal shaking diameter and rotation speed for improved mixing and oxygenation in bioreactors.
Texas researchers are studying microalgae's benefits, including its use as a sustainable source of fuels, animal feed and fertilizer. The microscopic algae thrive in freshwater and marine systems and have the potential to reduce greenhouse gas emissions.
Cornell scientists studied brewery bioreactor sludge, identifying unique microbial communities and their resilient populations. They hope to use this knowledge to shape these communities for producing carboxylates, a precursor to fuels.
Excess nitrogen in groundwater and water bodies harms aquatic life; new denitrifying bioreactors can treat agricultural runoff and urban wastewater at a lower cost. Research confirms successful operation in various settings, including agricultural fields and small townships.
bbi-biotech offers a novel sampling system that extracts sterile samples from bioreactors without dead volume, ensuring representative and contamination-free samples. The bioPROBE MK1 system facilitates at-line analysis and real-time monitoring of process status, enabling immediate regulation and optimization.
A team of scientists from the University of Sheffield has created an air-lift loop bioreactor that consumes less than 18% more energy, making it a significant breakthrough in the production of alternative renewable fuels. The device is now being tested with various organizations to reduce energy consumption and costs.
Researchers at Stanford University School of Medicine have developed a technique to generate solid organs using stem cells. By utilizing microcirculatory beds and a bioreactor, the team can keep tissue healthy enough for reimplantation into a second animal, overcoming the major hurdle of blood supply in tissue engineering. The techniqu...
A new study at Ohio State University Medical Center has successfully grown human blood platelets in a laboratory for transfusion. The three-dimensional bioreactor produced up to 1.2 million platelets per day, continuing production for over 32 days.