Researchers at Shenzhen Institute of Advanced Technology (SIAT) have developed a novel acoustothermal transfection device to enhance the permeability of cell and nuclear membranes. The study found that the method achieved efficient cargo delivery into hard-to-transfect cells with high efficiency.
Scientists from Tokyo Metropolitan University have created a new polymer that can effectively transport plasmid DNA into T-cells during CAR T-cell therapy. The polymer, called PAMAM-G2-Gu, is stable, non-toxic, and doesn't use viruses, making it a promising candidate for next-gen gene carriers.
Researchers developed a hybrid micro-robot that can navigate in physiological environments and capture targeted damaged cells. The micro-robot uses electric and magnetic mechanisms to identify and transport single cells for further study.
The Rutgers team has developed a microfluidic platform that detects membrane permeabilization in cells exposed to electric fields, allowing for efficient delivery of biomolecules. The technology improves transfection efficiency and cell viability, enabling the study and engineering of fundamental cellular processes.
Scientists at Tohoku University found that discharge plasma increases calcium ion influx through TRP channels, triggering cell activities like gene transfection and wound healing. This breakthrough may contribute to developing more efficient plasma medicine treatments.
Researchers at Toyohashi University of Technology have developed a novel gene-transfection method that uses electrostatic manipulation in water-in-oil droplets. This technique increases transfection efficiency and cell viability compared to traditional methods, offering promising applications in regenerative medicine and gene therapy.
Researchers at NYU-Poly and NYUCD developed a peptide-polymer hybrid that delivers DNA into cells five times more efficiently than existing commercial delivery methods. The study's findings could improve gene therapy by understanding gene function and introducing targeted gene editing.
Researchers developed a novel tool, nanofountain probe electroporation (NFP-E), to deliver molecules into targeted cells through temporary nanopores. The technique provides unprecedented control over cell transfection and has shown high efficiency and viability in HeLa cell experiments.
Researchers developed a method to induce transient ischemia during non-surgical interventional cardiac procedures, boosting adenovector gene transfection by over 100 fold. Cardium Therapeutics' Generx product candidate is being tested in a 100-patient Phase 3 trial for patients with myocardial ischemia and stable angina.
Researchers at Polytechnique Montréal developed a new transfection method that changes the genetic material of cancer cells, allowing for precise nanometric-scale surgery. This breakthrough could lead to new therapeutic approaches in oncology, neurology, and cardiology, with promising applications.
Amanda Rudisin, a Virginia Tech undergraduate, has developed polymers that can transport DNA across cell membranes. Her research found that linear and branched molecules have varying effects on complexation with DNA.