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Engineered microbe-based micro/nanorobots redefine interventional therapy for luminal cancers

Engineered microbe-based micro/nanorobots can revolutionize clinical intervention for luminal cancers by navigating and adapting to hostile luminal cavities. The review categorizes this living robotic paradigm into four synergistic capabilities, including active navigation, environmental sensing, and continuous biosynthesis.

SourceScience China Press·JournalMedicine Plus·TypeLiterature review·DateSep 3, 2026

Don't build the engine, grow it: biohybrid miniature robots using living organisms

Researchers create living biohybrid miniature robots that solve traditional engineering trade-offs between structural rigidity and environmental adaptability. These biological engines utilize embodied intelligence to navigate complex terrains and achieve performance metrics rivaling state-of-the-art synthetics.

SourceInternational Journal of Extreme Manufacturing·JournalInternational Journal of Extreme Manufacturing·DateApr 15, 2026

A nanoscale robotic cleaner

Researchers have developed light-driven nanorobots that can track down and collect bacteria, perform rapid 90° turns and selectively capture bacteria. The nanorobots enable controlled interaction with the microscopic world, opening possibilities for microbiology, biomedical research and targeted manipulation at the microscale.

SourceUniversity of Würzburg·JournalNature Communications·DateApr 8, 2026

Penn and UMich create world’s smallest programmable, autonomous robots

Researchers at Penn and UMich created microscopic swimming machines that can independently sense and respond to their surroundings, operate for months, and cost just a penny each. The robots are powered by light and can be programmed to move in complex patterns, sense local temperatures, and adjust their paths accordingly.

SourceUniversity of Pennsylvania School of Engineering and Applied Science·JournalScience Robotics·TypeExperimental study·DateDec 15, 2025

Malaria parasites are full of wildly spinning iron crystals. Scientists finally know why.

Researchers find that malaria parasites use a chemical reaction powered by hydrogen peroxide decomposition to make their iron crystals spin. This motion may be crucial for the parasite's survival, helping it to eliminate excess toxic chemicals and efficiently store essential heme.

SourceUniversity of Utah Health·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateOct 29, 2025

World's first MPI-trackable alginate-based microrobot: breakthrough platform enables targeted stimulation, position tracking, and cell delivery without cameras or radiation

Researchers developed an alginate-based microrobot that can be tracked using Magnetic Particle Imaging (MPI) and performs real-time localization, selective thermal therapy, and cell delivery. The robot is powered by a single magnetic actuation system independent of conventional medical imaging devices.

SourceInternational Journal of Extreme Manufacturing·JournalInternational Journal of Extreme Manufacturing·DateAug 12, 2025

Velcro DNA helps build nanorobotic Meccano

Scientists at the University of Sydney create programmable nanostructures using DNA origami, enabling rapid prototyping of diverse configurations. These custom-designed nanostructures have potential applications in targeted drug delivery, responsive materials, and energy-efficient optical signal processing.

SourceUniversity of Sydney·JournalScience Robotics·TypeExperimental study·DateNov 27, 2024

How can micro/nanorobots overcome the design and manufacturing bottleneck and drive future technological advancements?

Researchers have identified coupling design methods, composite manufacturing techniques, and future prospects for micro/nanorobots. The review explores three core functions: mobility, controllability, and load capacity, offering insights into designing high-performance MNRs.

SourceInternational Journal of Extreme Manufacturing·JournalInternational Journal of Extreme Manufacturing·DateSep 23, 2024

Nanorobot with hidden weapon kills cancer cells

Researchers at Karolinska Institutet developed nanorobots that target and kill cancer cells using a 'kill switch' activated in low pH environments. The study achieved a 70% reduction in tumour growth in mice, paving the way for further investigation into its potential as a cancer treatment.

SourceKarolinska Institutet·JournalNature Nanotechnology·TypeExperimental study·DateJul 1, 2024

Shape memory for nano-sized objects

Researchers at ETH Zurich have successfully applied the shape-memory effect to nano-sized objects, overcomes the limitation of objects needing to be larger than 50 nanometers. The material ferroic oxides showed a free-standing nanoscale structure made of ferroic oxides that are highly elastic and resilient.

SourceETH Zurich·JournalNature Communications·DateMar 9, 2023

Tiny bots that can deep clean teeth

Researchers at IISc and Theranautilus have developed nano-sized robots that can manipulate using a magnetic field to kill bacteria in dentinal tubules, improving the success rate of root canal treatments. The nanobots were able to penetrate further than previous methods, providing a safer alternative to harsh chemicals or antibiotics.

SourceIndian Institute of Science (IISc)·JournalAdvanced Healthcare Materials·DateMay 16, 2022

Tiny biohybrid robots for intelligent drug delivery

Biohybrid micro- and nanorobots promise to deliver drugs to body tissues with high precision, enabling tasks such as cancer treatment, cell microsurgery, and tissue engineering. Researchers envision incorporating novel biological components into robots to overcome immune responses and increase efficiency in manufacturing.

SourceBeijing Institute of Technology Press Co., Ltd·JournalCyborg and Bionic Systems·TypeExperimental study·DateMar 2, 2022

Nanobot pumps destroy nerve agents

Researchers create nanobot pumps that neutralize nerve agents and administer antidotes, powered by the enzyme's chemical energy. The technology has applications in medicine, manufacturing, robotics, and fluidics, and could be used to treat diseases like diabetes and deliver targeted treatments.

Nanorobot for transporting drugs in the body

Scientists at Aarhus University and Duke University have developed a DNA nanorobot that can encapsulate and release active biomolecules, including enzymes. The nanorobot uses temperature changes to open and close its structure, allowing for targeted drug delivery to diseased cells.

SourceAarhus University·JournalACS Nano·DateDec 2, 2013

Are nanobots on their way?

Researchers have built a proto-prototype nano assembler, a microscopic device capable of constructing nano machines. The NIST system uses micro-scale nanomanipulators to assemble complex structures on a small scale, with the potential for real-time imaging and low-cost production.

SourceInderscience Publishers·JournalInternational Journal of Nanomanufacturing·DateApr 28, 2008

World first in medical robotics

Researchers at École Polytechnique de Montréal have successfully guided a microdevice inside an artery using computer control and a clinical MRI system. The breakthrough could enable interventional medicine to target inaccessible sites using nanorobots.

SourcePolytechnique Montréal·JournalApplied Physics Letters·DateMar 16, 2007