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Study assesses seizure risk from stimulating thalamus

A new study by researchers at MIT and MGH found that even low stimulation currents could sometimes still cause electrographic seizures in awake mice, with a rate of 2.2 percent of tests experiencing seizures. The study cautions against the use of brain stimulation-based therapies without proper monitoring.

SourcePicower Institute at MIT·JournalBrain Stimulation·TypeExperimental study·DateAug 21, 2024
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The role of the cerebellum in absence seizures

Researchers at Ruhr-University Bochum found that stimulating cerebellar nuclei cells can prevent abnormal brain activity associated with absence seizures. The study used mice and optogenetic stimulation to confirm the therapeutic potential of targeted cerebellar stimulation.

SourceRuhr-University Bochum·JournalCellular and Molecular Life Sciences·DateMay 4, 2022

Absence epilepsy -- When the brain is like 'an orchestra without a conductor'

A team of researchers used 2-photon microscopy to visualize individual neurons during absence seizures, revealing uncoordinated firing activity instead of the expected rhythmic pattern. The study aims to better understand the underlying causes of absence epilepsy and potentially develop new treatments.

SourceBaylor College of Medicine·JournalNature Communications·DateJun 19, 2018

Research at Stanford locates absence epilepsy seizure 'choke point' in brain

Researchers at Stanford University School of Medicine used optogenetics to show that inducing synchronized activity in a specific nerve tract within the thalamus is sufficient to cause seizures, while disrupting it can terminate them. This finding may lead to improved ways of reducing or preventing absence seizures in susceptible child...

SourceStanford Medicine·JournalNeuron·DateDec 15, 2016
Celestron NexStar 8SE Computerized Telescope

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Researchers found an important clue to potential treatments for absence seizures

Researchers identified a key clue to treating absence seizures by deleting the T-type calcium channel CaV3.3 in mice, which suppressed burst firing and increased tonic firing. This study challenges existing hypotheses and provides a foundation for developing effective treatment methods.

SourceInstitute for Basic Science·JournalProceedings of the National Academy of Sciences·DateAug 21, 2014