Atherosclerotic Plaque
Articles tagged with Atherosclerotic Plaque
Immunotherapy reduces plaque in arteries of mice
A novel antibody-based therapy has been shown to reduce plaque in the arteries of mice, eliminating harmful immune cells that drive inflammation and unstable plaque formation. This immunotherapy could complement traditional methods and help patients with advanced coronary artery disease.
Scientists uncover how immune cell “fuel” shapes atherosclerosis
Two studies reveal that insufficient glutamine in macrophages drives atherosclerosis progression. Researchers identified new ways to detect high-risk plaques using protein markers like TREM2 and SLC7A7, which could lead to PET imaging and blood tests for early detection.
Study links genetic variants to higher 'bad' cholesterol and heart attack risk
A new resource identifies genetic variants associated with elevated 'bad' cholesterol, a major contributor to heart disease. Clinicians can now predict patient risk for heart attacks and strokes, allowing for prevention and early treatment.
Glucose-lowering medication classes and cardiovascular outcomes in patients with type 2 diabetes
This study found that GLP-1RAs and SGLT2is offer the greatest cardiovascular benefits for adults with type 2 diabetes. The magnitude of benefit depends on baseline age, atherosclerotic cardiovascular disease, heart failure, and kidney impairment.
Deep learning-based model enables fast and accurate stroke risk prediction
A deep learning-based model enables fast and accurate stroke risk prediction by segmenting carotid arterial vessel lumens, vessel walls, and plaques in MRI images. The model achieves high accuracy in plaque segmentation, outperforming manual methods, and completes assessment in under 3 seconds.
New gene variants significantly increase the risk of blood clots
Researchers at Lund University discovered three gene variants associated with a significantly increased risk of blood clots in the leg. These genetic mutations can lead to a 10-30% higher risk of venous thrombosis and are found in various populations worldwide.
Valentin Fuster, MD, PhD, wins prestigious award from the International Atherosclerosis Society
Valentin Fuster, MD, PhD, has made significant contributions to the understanding of atherosclerosis through his research on inflammation, thrombosis, and treatment breakthroughs. His work has led to major advances in diagnosis and therapy, including the development of a cardiovascular 'polypill' that reduces cardiovascular mortality.
Persistent racial disparities in vascular surgery outcomes
A recent study published in the Journal of Vascular Surgery found that non-white patients have twice the risk of dying within 30 days of carotid endarterectomy compared to white patients. The study analyzed data from over half a million patients and highlights persistent racial disparities in medical outcomes.
Taurine reduces atherosclerotic plaque area and stability in mice
This study investigated the effect of taurine on atherosclerotic plaques in mice. Taurine treatment significantly decreased plaque areas and lowered the ratio of anti-α-SMA to anti-CD68 staining, suggesting potential benefits for cardiovascular health.
Metal exposure can increase cardiovascular disease risk
A study published in JACC found that metal exposure is associated with progression of plaque buildup in the arteries, comparable to traditional risk factors like smoking and diabetes. The findings support considering metal exposure as a significant risk factor for atherosclerosis and cardiovascular disease.
Eating too much protein is bad for your arteries, and this amino acid is to blame
Researchers discovered that consuming over 22% of daily calories from protein can lead to increased activation of immune cells contributing to atherosclerotic plaque formation. Leucine, an amino acid found in animal-derived foods, plays a disproportionate role in driving pathological pathways linked to atherosclerosis.
Natto consumption suppresses arteriosclerosis
A study revealed that natto consumption significantly reduced atherosclerotic lesions in mouse models, altering intestinal microflora and regulating cytokine production. High vitamin K2 natto showed the most significant effect, decreasing pro-inflammatory cytokines while increasing anti-inflammatory IL-10 production.
Updated Canadian Cardiovascular Society Guidelines advise against routinely taking aspirin daily for primary prevention of heart attack or death but acknowledge there may be a role for some people
The Canadian Cardiovascular Society has updated its guidelines to no longer recommend routine daily aspirin use for primary prevention of heart attacks or death. However, daily aspirin may be considered for people with high risk factors for heart attack, such as diabetes, high cholesterol, and smoking. The new guidelines emphasize the ...
SARS-CoV-2 infects coronary arteries, increases plaque inflammation
Researchers found SARS-CoV-2 directly infects coronary arteries, causing fatty plaque to become inflamed. The virus replicates in macrophages, leading to increased inflammation and potentially worsening cardiovascular complications.
NIH awards The Texas Heart Institute $1.14 million to develop a novel, first-in-class drug for atherosclerotic cardiovascular disease
The Texas Heart Institute has been awarded $1.14 million by the NIH to develop a novel, first-in-class drug for treating atherosclerotic cardiovascular disease. The goal of this research is to target lingering inflammation in patients with cardiovascular disease.
New treatment method reduces size and increases stability of atherosclerotic plaque on arterial walls, preventing heart diseases: NUS study
Researchers at NUS have developed a new treatment method that reduces the size and increases the stability of atherosclerotic plaques in arterial walls. The treatment involves injecting omega-3 fatty acids into the bloodstream via nanomedicine, which helps to reduce inflammation and prevent plaque rupture.
New discoveries about where atherosclerotic plaques rupture can lead to preventive treatments
Researchers at Lund University have mapped the location where atherosclerotic plaques rupture, identifying an enzyme marker that could predict patients at risk of myocardial infarction or stroke. The study's findings may lead to preventive treatments and new therapies.
Physical activity trajectories and functional recovery after stroke
A study of 1,300 participants found that increased physical activity 6 months after stroke was associated with better functional outcomes. Interventions targeting individuals with decreasing physical activity in the subacute phase may play a role in improved functional recovery.
Asymptomatic, CT angiography-detected coronary artery disease associated with 8-fold increased risk for heart attack
A cohort study of over 9,000 persons found that asymptomatic middle-aged individuals with subclinical coronary atherosclerosis are at an 8-fold increased risk for myocardial infarction. The study highlights the importance of identifying and addressing obstructive coronary artery disease in patients without known cardiovascular disease.
A dietary supplement leads to remarkable regression in atherosclerotic lesions
Researchers from Osaka University found that tricaprin supplementation leads to remarkable regression of coronary artery plaque and resolution of symptoms in patients with triglyceride deposit cardiomyovasculopathy. The study's findings provide a novel treatment concept for coronary atherosclerosis.
Favine protein found to potentially protect against vascular disease
Researchers at Osaka University have developed a mouse model that shows Favine protein can protect against atherosclerosis and thrombosis. The study also found that reduced levels of Favine are associated with calcification and thrombus formation, revealing a new potential therapeutic target for treating atherosclerosis.
Study uncovers what happens inside artery plaque to trigger strokes
A study at Tulane University found that recently formed stroke plaques contain messenger RNA that causes inflammation and degrades a protective cap, leading to rupture. This discovery could lead to new tools to stop strokes from happening and develop new drugs or diagnostics to prevent heart attacks and strokes.
Blacks found twice as likely to have atherosclerosis as Hispanics in young adult populations in underserved communities
A new Mount Sinai study reveals that young Black adults are twice as likely to have atherosclerosis as their Hispanic counterparts. Researchers used comprehensive questionnaires and 3D vascular ultrasounds to determine cardiovascular risk scores, finding significant discrepancies between the groups.
Ultrasound-assisted laser technique vaporizes artery plaque #ASA182
Researchers developed a method combining low-power lasers with ultrasound to safely and efficiently remove arterial plaque. The technique reduces the risk of complications and improves the efficiency of plaque removal compared to traditional methods.
Exploring dynamics of blood flow in vascular, atherosclerotic diseases
Scientists use advanced measurement methods to study carotid artery stenosis, discovering significant gaps between their findings and clinical methods. They propose improvements for surgical treatment technology and future medical devices.
Atherosclerotic plaques “talk” with the brain
Researchers discovered a connection between atherosclerotic plaques and the central nervous system, involving immune cells, nerves, and cardiovascular tissues. This 'ABC' circuit can be modulated or disconnected, potentially leading to innovative therapies for treating atherosclerosis.
3D matrix ultrasound accurately identifies cardiovascular injury in healthy individuals
A new 3D matrix ultrasound method has been developed to assess cardiovascular risk in healthy individuals, offering a reliable and accurate alternative to traditional methods. The technique shows promise for personalized prevention and treatment strategies by detecting and quantifying an individual's accumulated cardiovascular damage.
A non-invasive way to predict heart attack and stroke
Researchers have made a significant breakthrough in predicting heart attacks and strokes by developing a non-invasive method using super-resolution ultrasound imaging. The technology aims to detect high-risk atherosclerotic plaques that are prone to rupture, allowing doctors to prescribe life-saving interventions.
New discovery on how omega-3 fatty acids can reduce atherosclerosis
Researchers at Karolinska Institutet discovered that omega-3 fatty acids activate the GPR32 receptor, which reduces inflammation in blood vessels and prevents atherosclerosis. This breakthrough discovery paves the way for new strategies to treat and prevent cardiovascular disease using omega-3 fatty acids.
Cytokine APRIL protects from atherosclerotic cardiovascular disease
Researchers discovered that cytokine APRIL protects against atherosclerosis by binding to proteoglycans in arteries, reducing plaque formation. High levels of non-canonical APRIL (nc-APRIL) in human blood predict risk of cardiovascular death.
Improved In vivo imaging of atherosclerotic plaque development
A team at University of Tsukuba developed a tool to image atherosclerotic plaque development in mice, allowing for the evaluation of drugs and analysis of individual patient risk. The method involves expressing fluorescent protein in immune cells that congregate in plaque, enabling accurate measurement of plaque quantity and progression.
Brown fat responsible for from heart disease-related deaths in winter
A new study published in Cell Metabolism suggests that cold exposure can accelerate the growth of atherosclerotic plaque in blood vessels, leading to increased risk of heart disease-related deaths. Brown fat activation has been linked to the formation of unstable plaques that can rupture and cause blockages in the heart and brain.