Articles tagged with Diabetic Retinopathy
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A WVU research team is working to restore vision in people with inherited blindness due to genetic mutations in the Prominin1 gene. The team has observed encouraging early results using a mouse model and plans to investigate the therapy's effectiveness beyond initial restoration.
A new technology allows for clear observation of living retina and microglia's behavior, revealing their increased activity before tissue damage in diabetic mice. The study found that the diabetes drug liraglutide reduced microglia's activity in healthy mice too, suggesting a direct modulation mechanism.
A team of researchers has received funding to study the PRPH2 gene, crucial for normal vision, but when mutated causes a range of retinal diseases leading to blindness. They aim to uncover the underlying mechanisms of PRPH2-associated pathology to develop effective therapies.
Researchers developed a first-trimester blood test that accurately predicts gestational diabetes risk, using just seven biomarkers. The test's strong ability to distinguish high-risk from low-risk pregnancies could enable early interventions and reduce long-term health burdens.
A study found no association between semaglutide treatment and diabetic retinopathy, but suggested a potential link to nonarteritic anterior ischemic optic neuropathy. Further research with larger sample sizes is needed to clarify this risk.
Cohort study finds GLP-1 receptor agonist use associated with modestly increased risk of incident diabetic retinopathy; however, those with preexisting DR experience fewer sight-threatening complications. Regular screening and monitoring recommended for all T2D patients on GLP-1 RAs.
A CU Anschutz study identifies a genetic variation in the GLP-1R gene that may explain why some children exposed to gestational diabetes become obese, while others don't. The study found that children with this variation gained weight faster and had higher BMI compared to those without.
Researchers found that an inexpensive HIV drug can improve vision in patients with diabetic macular edema (DME) more effectively and at a lower cost than existing treatments. The drug, lamivudine, is taken orally and may represent a game-changing option for millions of patients worldwide.
Researchers at Wayne State University are developing a new treatment to prevent diabetic corneal complications, which can lead to vision loss and poor healing. The project combines two naturally occurring peptides to target inflammation, delayed healing, and nerve degeneration.
A study led by Johns Hopkins Medicine researchers found that low blood sugar contributes to eye damage and vision loss in diabetic retinopathy. The research suggests that an experimental drug called 32-134D may help treat the condition by inhibiting the HIF protein, which triggers a chain reaction leading to blood vessel leakage.
A study found that patients with diabetes who recognize ophthalmology consultation recommendations are twice as likely to undergo a fundus examination. Individuals who recognized the recommendation were also more likely to understand the recommended frequency of ophthalmology visits.
A new study published in Lancet Gastroenterology and Hepatology found that a combined screening approach can detect liver damage in people with type 2 diabetes. The method involves elastography, an ultrasound-based technique, which was found to be willing to be adopted by most patients. Early detection of liver fibrosis is crucial, as ...
Empagliflozin was associated with a 22% lower risk of diabetic retinopathy progression in patients with early-stage non-proliferative DR. The study found that empagliflozin may be beneficial in slowing down progression to more advanced stages of DR in type 2 diabetes patients.
Researchers have introduced DSFN to improve the speed and accuracy of diagnoses of retinal disorders. This AI-powered medical imaging technique combines retina images with vascular distribution information to accurately locate the fovea in complex clinical scenarios, enabling doctors to detect early signs of ocular diseases.
This study found that certain social determinants of health affect monitoring for diabetic retinopathy differently for Black and white patients with diabetes. Patients living in rural communities, including Black patients with preexisting diabetic retinopathy, are not receiving eye care in accordance with clinical practice guidelines.
Researchers aim to find a new treatment pathway for diabetic retinopathy by targeting the IL-6 protein. They suspect that selectively inhibiting trans-signaling while allowing cis-signaling will stop damage and restore balance in the retina.
A Danish study published in The Journal of Dental Research found that individuals with diabetes complications are at higher risk of gum disease. Periodontitis was more common among those with microvascular complications such as retinopathy and neuropathy.
Scientists at the University of Augsburg have found that macrophages, also known as scavenger cells, form in the vitreous body of the mouse eye during embryonic development. This new understanding could lead to therapies for diseases like diabetic retinopathy and prenatal vessel defects.
Implementing diabetic retinopathy screening using in-clinic retinal photographs and automated software analysis increased screening rates among low-income minority patients. The clinic's strategy, including patient tracking and selective eye dilation, reduced the insufficient exam rate and improved detection rates.
A genetic variation common in people of African ancestry is associated with an increased risk of diabetic retinopathy and nephropathy. Testing for this variant could help clinicians diagnose and treat diabetes more effectively, reducing disparities in diabetes complications between individuals of European and African ancestries.
Researchers have developed a new treatment for diabetic retinopathy that addresses the root cause of the disease, preventing progression and potential blindness. The anti-ceramide immunotherapy has been shown to be effective in animal and cell culture models, offering a safer alternative to current treatments.
A long-term study published in the Journal of Epidemiology & Community Health found that men with diabetes are at a greater risk of developing cardiovascular disease, leg/foot complications, and eye disease compared to women. The study analyzed data from over 25,000 people with diabetes and found that men were 51% more likely to develo...
A study found that 670 nanometres of red light stimulated energy production within mitochondria, leading to increased glucose consumption and a 27.7% reduction in blood glucose levels. This non-invasive technique has the potential to impact diabetes control by reducing damaging fluctuations of blood glucose.
A new type of inhibitor drug has shown promise in preventing microvascular diabetic complications, including diabetic eye and kidney disease. Researchers have developed a novel class of drugs that target the glycocalyx lining, which is damaged in diabetes.
A new study published in Nature Communications found that AI-driven eye exams can close care gaps among racial and ethnic minority youth with diabetes, populations with historically higher rates of diabetic retinopathy. The technology uses cameras to take pictures of the back of the eye without dilation and provides immediate results.
Researchers develop a versatile imaging system for targeted spectroscopy in the eye fundus, allowing for continuous color imaging and spectral measurements. The system enables users to select targets and move them to any location within the eye fundus region without realignment or fixation changes.
Social determinants like food insecurity and housing issues were linked to lower likelihoods of receiving diabetic retinopathy screening. The study highlights the importance of addressing barriers to care for promoting health equity.
A retrospective study found that research staff of the same race or ethnicity as patients increased consent rates by 65.1% compared to those of a different race or ethnicity. Employing diverse research teams can improve trust and engagement among potential study participants, according to researchers.
A team of researchers has created a 'proteomic clock' that can predict a healthy person's age based on their protein profile, revealing accelerated aging due to diseases. The study also detected proteins associated with Parkinson's disease in eye fluid, offering a potential pathway for earlier diagnoses.
A UK study found that emergency department screening for type 2 diabetes could identify tens of thousands of previously undiagnosed cases every year. The study used the glycated haemoglobin test to screen 1,388 patients, yielding an additional 9% of type 2 diabetes cases and 30% of prediabetes cases.
A significant increase in the need for treatment of eye diseases is expected due to the growing elderly population. The number of patients requiring anti-VEGF medication is projected to rise by 50% over the next five years.
Researchers at Cedars-Sinai have identified two disease-associated changes to the cornea in diabetes patients that delay wound healing. The study proposes three therapeutic pathways that reversed these changes and partially restored wound-healing function, offering new potential treatments for diabetes.
Researchers have developed a biodegradable fluorescent nanoprobe to detect diabetic retinopathy (DR) at its early molecular stage. The nanoprobe binds to VEGFR-2, expressed in the retinal microvessels, allowing for early diagnosis and intervention.
In 2021, 9.6 million Americans had diabetic retinopathy and 1.84 million had vision-threatening forms. The number of people living with diabetes-related eye disease has grown since the last prevalence estimate in 2004.
Researchers developed an AI model to estimate best-corrected visual acuity from fundus photographs in patients with diabetic macular edema, achieving accuracy within one to two lines on a standard chart. The study's findings support the potential of AI in clinical settings, with opportunities for further improvement.
Researchers developed an experimental drug, 32-134D, that inhibits HIF protein levels, reducing blood vessel production and leakiness in diabetic eyes. The study shows promising results in both human cell models and mice, suggesting a safer therapeutic approach for diabetic eye disease.
Researchers have found a new target and drug combination that appears to stop the destruction of vision in premature newborns. By blocking ACAT1, an enzyme that converts cholesterol into smaller pieces, scientists can prevent the formation of leaky blood vessels and inflammation in the retina.
UVA scientists have discovered a new contributor to abnormal blood vessel growth in the eye, which could lead to new treatments for macular degeneration and other vision loss conditions. The discovery identifies a key protein that determines VEGF levels, blocking it has reduced VEGF levels significantly without unwanted side effects.
A recent study by the DRCR Retina Network found that early treatment with anti-VEGF drugs did not improve visual acuity in patients with diabetic retinopathy. The study enrolled 328 participants and used preventative injections to slow disease progression, but showed no benefit to vision.
A novel treatment involving ACE2-producing probiotic Lactobacillus paracasei may prevent or reverse diabetic retinopathy in Type 1 diabetes patients. The study found that human subjects with retinopathy had a dysregulated systemic RAS and profound gut permeability defects, which were reversed by the probiotic treatment.
Researchers have identified a Vegf-Notch signaling system that enables Muller glial cells to regenerate retinal neurons in zebrafish. This discovery may help understand why the human retina does not regenerate and could inform treatments for blindness.
A new study suggests that human retinal endothelial cells have a protective system against hyperglycemia, which delays the onset of diabetic retinopathy. Prolonged exposure to high glucose actually promotes cell recovery and resistance to damage.
Researchers explore the interactions between adipose tissues and surrounding blood vessels in connection with lipid metabolism and associated diseases. Targeting angiogenesis may provide a gateway for treating obesity, while its inhibition or promotion depends on the specific disease context.
A high-quality Nile rat genome sequence has been assembled, expanding its potential as a model organism for studying type 2 diabetes and disorders associated with disrupted circadian rhythms. The genome's long contigs and completeness make it suitable for investigating the genetic factors contributing to disease, including epigenetics.
Researchers found that increasing arginase 1 availability helps alleviate unhealthy responses and interrupt destructive inflammation in diabetic retinopathy and retinopathy of prematurity. This is achieved by reducing L-arginine levels, which in turn reduces inducible nitric oxide synthase activity.
A recent study found that patients vividly remember the way they were told they had their condition, which affects their perception of vision loss and interactions with others. Clinicians should consider empathetic communication when delivering bad news to minimize long-term psychological impact.
A specific step strategy, starting with a less expensive medicine and switching to a more expensive one if vision does not improve sufficiently, gives results similar to starting off with the higher-priced drug. After two years, both groups had similar visual acuity outcomes, improving on average approximately three lines on an eye chart.
A study found that telemedicine and community screening for diabetic retinopathy are highly cost-effective in rural and urban China. The results suggest that adopting telemedicine screening programs at the national primary care level is economically reasonable.
Researchers developed smart contact lenses that emit far-red light to treat diabetic retinopathy. The study showed the lenses prevented retinopathy in diabetic animal models, demonstrating their safety and effectiveness.
A comprehensive study investigates the metabolism of four drugs in rabbit eyes, revealing different enzyme profiles from liver metabolism. The findings provide valuable information for advancing ophthalmic drug development.
Researchers have discovered that a low-dose oral compound, HBI-002, can safely reduce oxidative stress and inflammation in the retina, common causes of diabetic retinopathy. The study suggests that small amounts of carbon monoxide may help protect vision in diabetes patients.
Researchers from Tokyo Medical and Dental University have developed a non-invasive imaging technique using blue light to identify areas affected by diabetic retinopathy. The study found that blue images obtained through multicolor widefield scanning laser ophthalmoscopy (SLO) can reveal hyporeflective areas indicative of damage associa...
Researchers identified a pattern that links the accumulation of amyloid beta (Aβ) proteins with a reduction of serotonin, which may help predict who will develop late-life depression. The study found that individuals expressing this pattern had more severe depressive symptoms.
Researchers at Indiana University School of Optometry have identified new biomarkers that can detect early eye changes associated with diabetes-related blindness. The study's findings may lead to earlier identification of people at risk for diabetes or visual impairment.
Researchers at Duke University developed a robotic imaging tool that can automatically detect and scan patients' eyes for eye diseases, producing clear images in under 50 seconds. The system uses optical coherence tomography and is designed to be safe and accessible for optometrist offices, primary-care clinics, and emergency departments.
A four-year clinical trial from the DRCR Retina Network found that early anti-VEGF injections slowed diabetic retinopathy progression, but did not improve vision at two years. Standard treatment remained effective in preventing further vision loss.
Researchers at Johns Hopkins Medicine used autonomous AI to detect pediatric diabetic retinopathy in a study of 310 patients. The AI tool achieved high sensitivity, specificity, and diagnosability rates, leading to improved screening adherence and early diagnosis.
Researchers tested seven AI screening algorithms against expert ophthalmologists and found that most perform poorly in real-world settings, highlighting the need for proper image quality and training data. Only one algorithm matched human screener performance.
A new 30-year study found that public health services worldwide have failed to meet targets for reducing avoidable sight loss, with cataract and uncorrected refractive error being major contributors. The number of cases of blindness and severe vision impairment is expected to rise dramatically by 2050.
A new study found that public health services are failing to meet targets to reduce avoidable sight loss, with a significant increase in cases despite a decrease in prevalence. Cataract is the leading cause of blindness, accounting for 15 million people, and treatable by surgery.