Articles tagged with Necrosis
A comprehensive review of surgery for necrotizing enterocolitis (NEC) in premature infants highlights the importance of preserving functional bowel, reducing long-term complications, and supporting survival with better quality of life. Emerging perioperative tools and risk scores may improve assessment and recovery.
A recent study reveals that MLKL activation causes direct damage to mitochondria, impairing energy production and leading to functional decline in hematopoietic stem cells. In contrast, deletion or inhibition of MLKL significantly alleviates these defects, suggesting a post-transcriptional mechanism driving HSC aging.
Intravenous tenecteplase administered 4.5 to 24 hours after ischemic stroke non–large vessel occlusion improved functional outcomes at 90 days compared to standard care. However, it also increased the risk of symptomatic intracranial hemorrhage.
Researchers have characterised how dying cells contribute to the body's regeneration process, suggesting a new mechanism for tissue repair. The study found that cells released from necrosis play a role in signaling the production of other cells involved in controlling natural cell death and inflammation.
Persistent microvascular over-dilation may cause muscle hypoxia, worsening chronic limb-threatening ischemia outcomes. Research suggests this phenomenon could be used to screen and treat patients with the disease.
A team of researchers from the University of Tokyo proposes a new mathematical definition of cell death based on enzymatic reactions and thermodynamics. This definition enables the development of computational methods to quantify the life-death boundary, which could lead to better understanding and control of cellular processes.
Researchers develop optogenetic system to precisely target cancer cells using light, inducing inflammatory cell death and triggering immune response. The approach aims to modulate the immune suppressive environment around cancer cells, helping T cells recognize and attack the disease.
Scientists have found an effective treatment for spitting cobra snakebites by blocking one of the major dermonecrosis-causing toxins with varespladib. The study suggests that this repurposed drug can prevent tissue damage and may become a valuable treatment against black-necked and red spitting cobra venoms.
Researchers assess vamorolone's promise in treating Duchenne muscular dystrophy, finding similar efficacy to prednisone but some reduced adverse side effects. However, further investigation is needed on its cost and mechanisms of action.
Researchers found that SARS-CoV-2 alters mitochondria on a genetic level, leading to widespread 'energy outages' throughout the body and its major organs. This affects the heart, brain, and lungs, contributing to long COVID symptoms.
A team of Chinese and UK researchers has identified superoxide dismutase 1 (SOD1) as a potential target for reversing drug resistance in ovarian cancer. By using nanoparticles to deliver siRNA that reduces SOD1 levels, the study showed reduced growth and decreased resistance to cisplatin in female mice.
A recent study confirmed which genes in the HiVir cluster are essential and which contribute partially to the disease. The toxin produced by Pantoea ananatis has broad-spectrum activity, potentially targeting conserved functions within plants.
Researchers found that necroptosis promotes metastasis in breast cancer models, and blocking it leads to inhibition of metastasis. Necroptosis may be a key factor in tumor progression, and targeting its regulators could be critical for mitigating metastasis.
A team of scientists from City University of Hong Kong and HKUST discovered novel, tridimensional compounds with high anticancer activity and low toxicity. These compounds can overcome drug resistance in cancer cells by inducing a different cell death pathway.
A six-year study involving 146 patients found that antivenom reduced the risk of skin necrosis in those bitten by brown recluse spiders. Administration of the substance was safe with minimal adverse effects, particularly when given within 48 hours of the incident.
A recent study led by University at Buffalo researchers found that photobiomodulation reduces inflammation, improves blood flow and heals wounds up to 19 days faster. Light therapy accelerated skin healing from cancer radiation therapy by an average of 49-42 days.
Researchers at University College London discovered that worm mothers secrete a milk-like fluid to support their offspring's growth. This unique selfless act helps explain mysteries about the biology of ageing in nematode worms, which could have far-reaching implications for understanding human ageing.
A new study led by Washington State University researchers has identified protein kinase A (PKA) as a potential target for improving treatment outcomes after a heart attack. The research suggests that PKA plays a role in heart muscle cell necrosis, a major type of cell death that commonly occurs after reperfusion therapy.
Researchers uncover that neuronal necrosis occurs earlier in Alzheimer's progression than thought and identifies YAP as a key regulator. Early intervention with YAP supplementation can prevent neuron loss, restore cognitive function, and reduce beta-amyloid plaques.
A preclinical trial found that retinoid X receptor (RXR) enhances the clearance of dead cells and debris in the brain after a stroke, limiting inflammation and improving recovery. RXR activation could lead to discovery of a promising new therapeutic target for improving neurological outcomes.
Bacteria do not die randomly in hunger phases; their neighbors play a crucial role. The team identified two key factors: basic energy consumption and biomass recycling efficiency. Changes to these factors affect the mortality rate, which can arise from genetic or ecological perturbations.
New research at the University of Sheffield reveals that dead cells can disrupt the normal function of immune cells, called macrophages, which are crucial for responding to wounds and patrolling for infection. The study's findings could lead to new therapies to manipulate white blood cells and accelerate healing processes.
The presence of reactive oxygen species (ROS) drives the digestion process of dead cells through efferocytosis. This mechanism helps limit host inflammation and regulates the immune response. Producing optimal levels of ROS is essential to prevent autoimmune disease and chronic conditions.
Researchers discovered that Axl and Mer receptors work in different settings to recognize and engulf dead cells. The study found multiple critical differences between the receptors, including their ligand use and regulation.
A University of Michigan study found two critical components involved in the brain's cell clearing process: TRPML1 calcium channel protein and an alipid molecule. The researchers also identified a synthetic chemical compound that can activate TRPML1, potentially providing a drug target for combating neurological diseases.
A study published in PRS Global Open found that the weight of tissue flaps used in breast reconstruction significantly increases the risk of fat necrosis. Flaps weighing over 650 grams had a higher risk of fat necrosis, with African American women being at nearly 12 times higher risk than Caucasian women.
A recent Weizmann Institute study has discovered that caspase 8 signaling enzymes, which were previously thought to only induce programmed cell death, can also activate an entirely different process in certain cells - causing inflammation more directly. This finding highlights the need for further research into the signals transmitted ...
A study found that combined treatments for severe acute pancreatitis are safe and effective in managing the disease, resulting in shorter hospitalizations and fewer radiological procedures. Primary conservative treatment also showed promise in avoiding surgery and improving patient outcomes.
A recent study assessing nasal ventilation in newborns reveals that nearly 1 in 7 infants (12%) develop internal nasal complications while receiving oxygenation and ventilation support. The primary external complication found was columellar necrosis, which can lead to adverse cosmetic results if left untreated.
Researchers have identified a specific gene and protein that contribute to the development of deadly arterial plaques. Deleting this gene in mice resulted in smaller, less unstable plaques. The study suggests that therapies targeting cellular stress may be useful in treating heart disease.
A University of British Columbia study found that popular osteoporosis drugs like Actonel, Didrocal, and Fosamax nearly triple the risk of developing bone necrosis. Researchers also discovered that this condition primarily affects shoulders, knees, and hips.
Researchers find that mis-regulated immune systems can establish reproductive barriers in plants, leading to hybrid necrosis. This phenomenon challenges the classical definition of a species and suggests that speciation may be a gradual process.
A study found that a mis-regulated plant immune system can establish reproductive barriers, potentially leading to speciation. Researchers discovered that hybrid necrosis, a syndrome affecting unfit hybrids, is caused by a common group of genes being more strongly or weakly active in the hybrids than in their parents.
A study published in the Canadian Medical Association Journal found that levels of ischemia-modified albumin provided no useful information in predicting which patients with potential acute coronary syndrome would experience serious cardiac outcomes. The analysis suggests that prognosis may precede diagnosis in these cases.