Articles tagged with Retinoblastoma
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Researchers found a genetic change, pR552*, that could give the RB1 gene a new function leading to cancer growth. This challenges the common belief that both copies of the RB1 gene must be damaged for cancer to develop.
A team led by CHLA's Dr. Jesse Berry is conducting an international liquid biopsy retinoblastoma study to investigate the use of liquid biopsies for diagnosis and disease severity determination. The study will provide valuable genetic and chromosomal information, enabling oncologists to diagnose retinoblastoma at a molecular level.
Scientists have identified estrogen-related receptor gamma (ESRRG) as a key molecular driver of retinoblastoma. Blocking ESRRG kills retinoblastoma cells, even under low-oxygen conditions. This breakthrough discovery offers new hope for treating this rare cancer.
A recent study published in The Lancet Global Health reveals stark differences in survival rates for children with retinoblastoma between high- and low-income countries. In low-income countries, the risk of death from retinoblastoma within three years of diagnosis is significantly higher, with over two-fifths of children dying within t...
Pediatric cancer patients from lower- and middle-income countries faced a higher risk of all-cause mortality than those in high-income countries during the COVID-19 pandemic. The study found that patients in LMICs had 35.7 times the risk of all-cause mortality compared to those in HICs.
Researchers found that piperlongumine inhibits cell growth, impacts cell cycle, and triggers caspase-3 independent cell death in retinoblastoma cell lines. PL's toxicity was inhibited by a ROS scavenger treatment, suggesting its potential as an anticancer molecule for retinoblastoma treatment.
Researchers found that retinoblastoma survivors who received treatment began to recover their early learning and life skills by age 10. The study highlights the importance of early intervention to promote growth and development in young children with retinoblastoma.
Researchers at UNC Lineberger Comprehensive Cancer Center developed a therapy using immune system T cells and an immune-boosting drug packaged in a gel to preserve vision in mice implanted with retinoblastoma. The therapy successfully delayed tumor development and prevented recurrence, showing promise for future clinical trials.
Researchers at Children's Hospital Los Angeles have developed a novel way to biopsy retinoblastoma, allowing for more accurate diagnoses and access to studying the disease on a molecular level. This breakthrough discovery has the potential to drastically improve retinoblastoma research and clinical practice.
A Baylor University researcher's prototype smartphone app, CRADLE, detects early signs of various eye diseases in children by searching for abnormal reflections from the retina. The app surpassed the 'gold standard' of sensitivity and detected leukocoria with 80% accuracy.
Retinoblastoma arises from abnormal proliferation of cone cells due to a tumor-suppressing gene mutation. Dr. Cobrinik's research aims to understand how RB mutations affect cone cells, which could lead to new cancer therapies.
Researchers developed a virus-based therapy VCN-01 that targets retinoblastoma, a tumor affecting mainly children, by infecting cancer cells with a dysfunctional RB1 pathway. The treatment successfully replicated in tumor cells without causing systemic inflammation and extended time to enucleation compared to chemotherapy.
Johns Hopkins researchers discovered that blocking the activin receptor can suppress the growth and spread of retinoblastoma cells, halting the cancer's progression. The therapy showed promising results in both human cells and zebra fish, offering new hope for treating this deadly eye cancer in children.
Researchers at Children's Hospital Los Angeles have pinpointed the exact stage of development of the human retina when cells can grow out of control and form cancer-like masses. The finding could lead to future interventions in retinoblastoma, a tumor affecting children under five years of age.
Children considered at risk for retinoblastoma should receive genetic counseling and testing as soon as possible to detect the disease early. The new guidelines aim to improve care for these children by focusing on those at highest risk while reducing unnecessary examinations.
Researchers at Children's Hospital Los Angeles developed a safe and effective way to derive genetic information from retinoblastoma tumors without removing the eye. The technique uses aqueous humor, which contains tumor DNA, to provide valuable insights for diagnosis and treatment.
Researchers at Children's Hospital Los Angeles identified a critical role of the MDM2 oncogene in promoting expression of the MYCN oncogene required for retinoblastoma cell growth and survival. The study found that MDM2 promotes MYCN expression, which plays a key role in cell proliferation.
A study by St. Jude Children's Research Hospital found that triple-drug chemotherapy with topotecan improved survival of eyes and useful vision in patients with advanced localized disease, compared to standard chemotherapy including etoposide.
Researchers at Children's Hospital Los Angeles found that targeting survivin enhances chemotherapy effectiveness in retinoblastoma cells and mouse models. The combination of a survivin inhibitor with chemotherapy agents increased Rb cell death, demonstrating a therapeutic advantage.
A study led by Michigan State University reveals that the retinoblastoma tumor suppressor protein controls cell migration in fruit flies and humans, contributing to cancer metastasis. The researchers also found that this protein regulates polarity genes important for maintaining proper cell organization and specialized functions.
A new study reveals that adult retinoblastoma survivors are at higher risk of developing various medical problems, including second cancers, compared to unaffected individuals. Despite this, the majority of survivors report excellent general health and minimal long-term impact on their psychological or socio-economic outcomes.
A study published in CANCER found that adult survivors of retinoblastoma have few cognitive or social problems decades after diagnosis and treatment. The research suggests the brain may adapt to early insults, with some survivors performing better on verbal memory tasks.
A St. Jude Children's Research Hospital study found that adult survivors of retinoblastoma, particularly those diagnosed in infancy, have normal cognitive function and fulfill milestones of adult life. The brain may compensate for early visual loss by reorganizing areas responsible for processing verbal and auditory information.
Researchers at Children's Hospital Los Angeles discovered the origin of retinoblastoma tumors in young children, revealing a single genetic change in the RB1 gene. This finding holds promise for developing novel therapies and advancing understanding of cancer development.
Research suggests that shortening the time from symptoms to diagnosis has no bearing on survival or disease stage for most children with unilateral retinoblastoma. However, a longer lag-time between symptom onset and diagnosis is associated with a more advanced stage and worse survival in bilateral cases.
Digital photography shows promise as a tool to detect retinoblastoma in its earliest stages. A study found that analyzing family photographs can identify leukocoria, a symptom of the disease.
A study analyzing 203 children with retinoblastoma found that delays in diagnosis led to more invasive and life-threatening disease courses in non-white, Hispanic, or uninsured patients. The researchers aim to explore the causes of these delays and eliminate them.
A new type of retinoblastoma has been discovered, driven by an oncogene, and is found in babies with no family history. The cancer starts long before birth and can be identified through molecular diagnostics.
Michigan State University researchers have identified a unique protein that regulates cell growth and controls excessive cell proliferation. The study focuses on Retinoblastoma tumor suppressor proteins, which use controlled destruction to perform their jobs, highlighting new potential ways to treat cancer.
A study found that DCIS patients with combined RB and PTEN loss are at high risk of progressing to invasive breast cancer. Women lacking both genes are over 5 times more likely to develop invasive breast cancer.
US-born Latina women are at higher risk of having children with retinoblastoma due to factors like poorer diets and smoking during pregnancy. In contrast, Mexican-born Latinas are at lesser risk, possibly due to healthier behaviors after immigration.
Researchers have made significant advancements in treating autoimmune diabetes by harnessing the power of gut bacteria. Additionally, studies on cancer treatment and tumor growth have revealed that vascular normalization can prevent dangerous side effects while enhancing anti-tumor effects. Furthermore, scientists have discovered a coo...
Researchers at St. Jude Children's Research Hospital have identified a new mechanism behind the rapid growth of retinoblastoma, a rare childhood eye tumor. The study found that epigenetic factors play a crucial role in cancer progression, linking an abnormal gene to aggressive tumor growth.
A multidisciplinary team approach to genetic testing in retinoblastoma patients ensures timely evaluation and appropriate counseling, improving risk prediction for patients and family members. Genetic testing also prevents overutilization of clinical screening tests, reducing potential morbidity for relatives.
A study by Baylor College of Medicine reveals the benefits of genetic evaluation in managing retinoblastoma, a childhood eye cancer. The research showed that genetic analysis helped identify hereditary cases and determined at-risk relatives, reducing unnecessary screening.
Researchers at St. Jude Children's Research Hospital identified a hybrid cell as the origin of childhood eye tumor retinoblastoma, which has been linked to multiple developmental pathways being turned on simultaneously. The study also found that blocking certain chemicals reduced growth in human retinoblastoma cells, providing a potent...
Researchers found reduced p16INK4a RNA expression and demethylation of the gene in 55% of patients, suggesting a novel susceptibility marker. Low to moderate 16INK4A protein expression was also detected in 45% of retinoblastoma tumor specimens.
A large cohort study found that long-term survivors of hereditary retinoblastoma are at a significantly increased risk of death due to subsequent cancers. Hereditary retinoblastoma survivors had a 35-fold higher mortality rate compared to the general population.
Researchers found that among women under 40, black women have a higher breast cancer incidence rate than white women. However, this trend reverses among women over 40, with white women having a higher incidence rate. The study confirms the age-related crossover effect in breast cancer incidence rates between black and white ethnic groups.
Researchers found a significant increase in soft tissue sarcoma cases among hereditary retinoblastoma survivors, with leiomyosarcoma being the most common subtype. Regular medical surveillance is crucial for these patients to detect potential cancers early.
Researchers have developed a localized treatment that shrinks retinoblastoma tumors while avoiding chemotherapy side effects. The new treatment shows promise against certain breast, lung, prostate and colon cancers, offering a simpler and more effective alternative to current therapies.
A new study by St. Jude investigators reveals the role of several key genes in retina development and suggests new studies for designing more effective drugs to treat retinoblastoma. The study found that humans are more susceptible to developing eye cancer due to a difference in gene expression between mice and humans.
Researchers found that in mice, proteins Rb and p107 compensate for each other in retinal progenitor cells, preventing deregulated proliferation that leads to retinoblastoma. In contrast, humans lack these compensatory mechanisms due to the main protein RB1, leading to retinoblastoma.
A new treatment approach using topotecan and carboplatin eliminates the need for etoposide, reducing the risk of leukemia. The study also suggests that vincristine contributes little to treating retinoblastoma, making it a promising alternative.
Researchers at Temple University have found a link between the Rb2/P130 gene and lung cancer, with epigenetic activity causing the gene to be silenced. A simple genetic test could identify cancerous or pre-cancerous conditions using this epigenetic state.
Knudson's two-hit theory explained the hereditary and sporadic forms of retinoblastoma, launching the study of tumor suppressor genes. His work has profoundly influenced cancer research, guiding countless geneticists and molecular biologists.
Researchers discovered specific retinal cells are predisposed to becoming tumours due to genetic mutation removing protective barriers. The study found three types of cells resistant to cell death and continued dividing despite the defective gene.
Researchers developed a reliable animal model to test new drugs for retinoblastoma, a deadly childhood cancer. The model has already identified a promising new treatment being studied in clinical trials.
The study reveals Rb protein is crucial for retinal cell proliferation and rod development, providing clues to improving treatment of retinoblastoma. Understanding Rb's role in normal mouse development can help explain why mice without the gene don't develop the disease.
A 57-year study found that hereditary retinoblastoma patients have a significantly higher risk of developing a second primary cancer, with an increased incidence of melanomas and sarcomas. The risk is independent of radiotherapy treatment.
Researchers at St. Jude Children's Hospital have successfully treated four pediatric patients with retinoblastoma using a combination of chemotherapy, radiation therapy, and stem-cell transplantation. The study shows promising results, with two out of four patients surviving for over six years without disease recurrence.
Dutch researchers found a possible link between IVF and eye cancer in children. The study suggests that IVF children are 5-7 times more likely to develop retinoblastoma, a rare form of childhood eye cancer. Researchers are now calling for closer follow-up and monitoring of IVF-conceived children.
Researchers at Albert Einstein College of Medicine found that Id2 gene is implicated in neuroblastoma development and underlies tumor growth. The study suggests developing drugs to counteract the Id2 gene may provide targeted treatment for neuroblastoma and other cancers.