Articles tagged with Antitoxins
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Researchers created new proteins using AI that bind to and neutralize deadly snake toxins, providing a safer alternative to traditional antivenoms. The study's results show an 80-100% survival rate in mice, offering potential benefits for people in developing countries.
A team of scientists at the University of Sydney has repurposed a commonly used blood thinner, heparin, as an inexpensive antidote for cobra venom. The discovery could drastically reduce the impact of snakebites worldwide, particularly in low- and middle-income countries where cobra species account for most snakebite incidents.
Researchers have developed nanodiscs based on the cell membranes of human red blood cells, which can effectively neutralize bacterial toxins. These nanodiscs, called RBC-NDs, are biocompatible and non-toxic, making them potentially useful as nanovaccines.
Caulobacter crescentus uses a toxin-antitoxin system to regulate programmed cell death in response to oxygen limitation, releasing DNA that promotes sibling dispersion. This mechanism helps maintain biofilm balance and prevents overcrowding.
Researchers have discovered a new toxin-antitoxin system that allows bacteria to slow down their activity and thrive during periods of scarcity. The HEPN/MNT system, the most abundant TA system in prokaryotes, enables bacteria to conserve energy and resources by inhibiting toxin production.
Researchers at Skoltech identify a component of a bacterial self-defense system that works by targeting transfer RNAs for glycine, disrupting translation and protein synthesis. The discovery may lead to the development of powerful new antibiotics by controlling each step of protein synthesis.
Researchers developed bifunctional nanobodies that neutralize multiple types of botulinum neurotoxins, including Botox, with greater potency than single-nanobody approaches. The findings address urgent need for antitoxins against Tier 1 select agents.
Researchers develop animal-free antitoxin to block diphtheria toxin, reducing animal suffering and increasing safety. PETA-funded project uses human blood cells to create effective treatment with no risk of allergic reactions.
A global shortage of diphtheria treatment drugs due to lack of market incentive poses a significant threat to Western nations. Experts warn that the medicine is only produced in limited quantities and its availability is compromised by European-wide efforts to coordinate a stockpile.
A team of researchers has identified an oxygen-dependent toxin antitoxin system that can be targeted to inhibit biofilm formation and combat antibiotic-resistant bacteria. By understanding the molecular mechanisms behind this system, scientists hope to develop more effective antimicrobials.
Scientists at Université de Genève found a novel regulatory mechanism in the HigBA toxin-antitoxin system that can selectively kill bacteria when they suffer from DNA damage. This discovery could lead to new treatments for bacterial infections by forcing bacteria to turn their weapons against themselves.
Engineered anti-toxin antibodies have been shown to increase toxin neutralization activity by enhancing the interaction between toxins and Fc receptors on immune cells, improving protection against anthrax toxin. Additionally, prenatal retinoid deficiency has been linked to airway hyperresponsiveness in adult mice, highlighting the imp...
Researchers at The Rockefeller University demonstrate that engineering Fc domains of anti-toxin antibodies enhances toxin neutralization activity. Mice expressing humanized FcR were better protected from anthrax toxin when given engineered anti-anthrax toxin antibodies.
A Utah prison outbreak of severe botulism poisoning from homemade pruno highlights the importance of prompt medical attention. The CDC's anti-toxin is rarely administered due to lengthy supply chains, emphasizing the need for emergency physicians to act quickly on clinical suspicion.
A novel 'beads on a string' approach may help reduce cost and development time for agents that neutralize and clear pathogenic molecules. The strategy has been shown to be efficacious against several toxins and may also prove effective in targeting other types of pathogens.
Scientists at Washington University School of Medicine have identified a protective mechanism in Streptococcus pyogenes that could be exploited to create new antibiotics. The discovery reveals how the antitoxin blocks the toxin's activity, sparing the bacteria from self-destruction.
Researchers at Brown University have discovered a couple of prime suspect genes, MqsR and MqsA, that control the formation of biofilms by regulating persister cell growth. The investigation provides a new avenue for developing novel sets of antibiotics targeting these proteins.
Researchers at VIB have determined the structure and operating mechanism of a deadly toxin-antitoxin system found in bacteria. The discovery provides new avenues for developing a class of antibiotics to combat bacterial threats.
A new high-affinity antibody successfully eliminated anthrax bacteria and its deadly toxins in animal tests, offering a promising treatment for late-stage anthrax infection. The antibody produced in bacterial cells could lead to a simpler and cheaper way to treat anthrax, providing an effective treatment that doesn't require antibiotics.
A recent study highlights the need for cheaper antitoxins to treat plant poisoning in developing countries. The research found that removing an expensive antitoxin led to a significant increase in deaths, emphasizing the importance of affordable treatments.