Articles tagged with Costimulation
A cost analysis suggests Lecanemab, an antidementia medication with modest clinical benefit, could add billions to Medicare spending each year. Beneficiaries without supplemental coverage would face substantial out-of-pocket costs.
Researchers at the University of Pittsburgh have discovered that even terminally exhausted T cells retain some capacity to function again. They identified approaches to overcome exhaustion by targeting co-stimulation pathways and reprogramming T cells to be resistant to hypoxia, a common tumor microenvironmental signal.
A study by Dr Jay S Skyler and colleagues found that abatacept slows the loss of insulin-producing beta-cells in type 1 diabetes patients, but only for the first six months. The treatment helps modulate T-cell activation, resulting in higher C-peptide levels.
Researchers at Emory Transplant Center developed a combination therapy that replaces calcineurin inhibitors with costimulation blockers and alefacept, reducing rejection rates in monkey transplants. The new regimen allows for less-toxic post-transplant treatment, potentially administered once a week.
Researchers aim to achieve permanent tolerance without immunosuppressive medication for hand transplants, potentially allowing patients to reject donor tissue. A new protocol using costimulation-blocking antibodies has extended the survival of transplanted limbs in mice, paving the way for future clinical trials.