Renowned cell therapy expert establishes new laboratory at Weill Cornell Medicine
Dr. George Coukos, a leading authority on tumor immunology and cellular immunotherapy, joins Weill Cornell Medicine to lead the Ludwig Laboratory for Cell Therapy.
Immunotherapy
Articles tagged with Immunotherapy
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Immunotherapy reduces plaque in arteries of mice
A novel antibody-based therapy has been shown to reduce plaque in the arteries of mice, eliminating harmful immune cells that drive inflammation and unstable plaque formation. This immunotherapy could complement traditional methods and help patients with advanced coronary artery disease.
Immunotherapy before surgery helps shrink tumors in patients with desmoplastic melanoma
A new clinical trial shows that treating desmoplastic melanoma with immunotherapy before surgery dramatically shrinks or eliminates tumors, improving quality of life for patients. The study found that 71% of patients had no detectable cancer remaining at the time of surgery.
Lipid droplets in the tumor microenvironment
Lipid droplets regulate diverse cellular processes in cancer, including membrane biosynthesis and metabolic homeostasis. Targeting lipid metabolism may disrupt tumor survival and counteract immune cell-mediated protumorigenic effects.
Mount Sinai study finds antibody-producing immune cells can help shape cancer immunotherapy
A Mount Sinai study found that antibody-producing immune cells called IgG1 plasma cells help patients respond to PD-1 immune checkpoint inhibitors, which have transformed cancer care. The researchers identified IgG1 plasma cells as a critical factor in determining clinical outcomes.
How do nature and nurture shape our immune cells?
Researchers at Salk Institute debut an epigenetic catalog that shows genetic inheritance and life experiences have distinct effects on various types of immune cells, shedding light on individual differences in immune responses and potential new personalized therapeutics.
Chinese Medical Journal article review: cGAS‑STING pathway emerges as cornerstone for next‑generation immunotherapies
The cGAS-STING pathway plays a crucial role in detecting cellular DNA, triggering type I interferons and cytokines, and modulating immune responses. Its therapeutic potential is being explored in cancer and various diseases, with promising preclinical evidence suggesting its potential as a target for next-generation immunotherapies.
A research redefines the role of neutrophils and opens new avenues for cancer and inflammation therapies
Researchers propose a new conceptual framework for neutrophils, highlighting their dynamic and adaptable nature. The study reveals neutrophils' functional diversification and immunological memory capabilities, opening avenues for innovative therapeutic strategies.
Hope for smarter lung cancer care
A study from Flinders University found that patients with progressive disease, which describes the way cancer grows, have varying survival rates depending on whether their existing tumours re-grow or new ones appear. Understanding this progression can help doctors make better decisions about future treatment strategies.
Immunotherapy success could be predicted with new biomarkers
Researchers discovered that CHD1 and MAP3K7 gene deletion improves tumor vulnerability to immunotherapy. This finding suggests new biomarkers for predicting patient response and opening up personalized cancer care. The study sheds light on why some patients are more or less likely to respond to certain types of cancer treatments.
“Recipe book” for reprogramming immune cells
Researchers have created a library of over 400 immune-related factors to reprogram rare immune cell populations. This technique allows for the systematic discovery of 'recipes' for specific immune cells, offering hope for unresponsive patients and advancing immunotherapy.
TB and HIV treatments are not enough for a full recovery
A team at Texas Biomedical Research Institute found that even with effective treatments for TB and HIV, the immune system remains seriously out-of-whack following treatment. The study suggests that host-directed therapies specifically targeting the immune system could potentially restore lung immune system functionality.
Blood test predicts which patients with lung cancer will benefit from newly approved immunotherapy drug
A new blood test has been developed to predict which patients with lung cancer will benefit from the newly approved immunotherapy drug tarlatamab. The test, based on circulating tumor cells, correctly identified 85% of patients who responded to the drug and 100% of those who did not.
Gut bacteria molecule boosts lung cancer treatment response
Researchers at the University of Florida have discovered a small compound produced by gut bacteria that doubles the response to lung cancer immunotherapy treatment in mice. The findings could lead to a new combination therapy that boosts patient responsiveness by 50% without adding invasive treatments.
Novel immunotherapy demonstrates early potential to overcome resistance to immune checkpoint therapy
A Phase I study led by Timothy Yap demonstrates the potential of linavonkibart to target and prevent activation of transforming growth factor-beta 1 (TGFβ1), overcoming treatment resistance in multiple cancers. The trial showed manageable safety profiles and objective responses in heavily pre-treated patients, suggesting a promising ne...
Study: ADRIATIC clinical trial results suggest durvalumab may offer a new path in small cell lung cancer care
A new study suggests that durvalumab may offer a promising treatment option for limited-stage small cell lung cancer patients, extending overall and progression-free survival. However, the therapy's high cost poses significant challenges to sustainability and access in the real-world setting.
MD Anderson shares latest research breakthroughs
Researchers at MD Anderson have made significant advancements in cancer treatment, demonstrating the effectiveness of immunotherapy before and after surgery in improving lung cancer patient outcomes. Additionally, a new study shows promise in using CAR T cell therapy to treat large B-cell lymphoma, reducing relapse rates.
Strengthened immune defense against cancer
Researchers have identified a new class of molecules that specifically degrade the cancer-promoting enzyme IDO1, offering a potential solution to enhance checkpoint-based immunotherapy. These IDO1 degraders may overcome limitations of previous inhibitors and open new avenues for treating various types of cancers.
Victoria’s Secret grant backs cutting-edge ovarian cancer research
Melanie Rutkowski's pioneering research may lead to novel immunotherapy treatments for ovarian cancer by understanding how faulty cellular signaling interacts with the microbiome. The grant aims to enhance immune system's ability to kill cancer cells and improve patient outcomes.
Some antibodies outmaneuver germs from sticking to cells
Researchers discovered that certain antibodies employ unusual tactics to block bacterial adhesion, including creating molecular wedges and conformational traps. These mechanisms could lead to the development of immune therapies targeting glycan-binding cell-attachment proteins produced by bacteria causing urinary tract infections.
Breast cancer hijacks immune alarm: turning defense into cancer-fueling inflammation
Researchers discover breast cancer cells hijack the immune system's alarm pathway, inducing chronic pro-tumor inflammation. This shift creates a vulnerability that can be targeted by existing immunotherapies.
Low-dose peanut therapy may help protect more kids with peanut allergy
A new study found that a small dose of peanut oral immunotherapy can help children with their peanut allergy and reduce the risk of severe reactions from accidental exposures. Children receiving the low-dose treatment experienced significant increases in their allergic reaction threshold to peanuts.
Review highlights novel targets in immunotherapy for multiple myeloma
Recent advances in immunotherapy have transformed multiple myeloma treatment, offering durable survival benefits. Emerging targets such as regulatory T cells, myeloid-derived suppressor cells, and tumor-associated macrophages are being explored to enhance treatment efficacy.
Promising target improves antitumor response in preclinical models of pancreatic cancer
Researchers at MD Anderson Cancer Center have found that inhibiting GFER, a mitochondrial enzyme, in combination with immune checkpoint blockade improves antitumor response in preclinical models. This two-pronged approach holds promise for patients with pancreatic cancer.
Engineering dendritic cells boosts cancer immunotherapy
Researchers at EPFL have developed two bioengineering approaches that exploit extracellular vesicles to train dendritic cells to identify cancer cells without the need for tumor material. The approaches, published in Nature Communications and Science Translational Medicine, show promising results in enhancing cancer immunotherapy.
This new understanding of T cell receptors may improve cancer immunotherapies
Researchers at Rockefeller University discovered that the T cell receptor springs open when activated by an antigen, contrary to previous studies. This finding could lead to next-generation treatments for a broader group of cancer patients.
Large-scale study provides real-world data on rare side effect of cancer immunotherapy
A large-scale study identified risk factors and clinical features of ICI-ITP, a rare but serious complication of anti-cancer immunotherapy. The study found that patients with ICI-ITP tend to have lower platelet counts at the start of treatment, experience additional immune-related adverse events, and have a higher risk of death.
Identification of an immuno-inflammatory biomarker in the brain supports potentially more effective personalized treatment for major psychiatric disorders
A study published in Biological Psychiatry identifies a distinct immuno-inflammatory biomarker in the brain linked to immune system dysfunction and poorer response to standard treatments. The findings provide potential value for clinical prediction and precision therapies.
Gut health à la CAR T
Researchers at Cold Spring Harbor Laboratory have devised a new approach to stimulate cell growth and repair in the intestine using CAR T-cell therapy. This therapy has shown promising results in improving gut health in both young and old mice, with significant reductions in inflammation and improved nutrient absorption.
Mayo Clinic researchers find new hope for toughest myeloma through off-the-shelf immunotherapy
A new Mayo Clinic study found that an off-the-shelf dual-antibody therapy generates deep and durable responses in extramedullary multiple myeloma. In a trial of 90 patients, 79% responded to treatment, with nearly two-thirds maintaining disease control at one year.
JMC Publication: Insilico’s Chemistry42 empowered efficient discovery of potent, oral CBLB inhibitor for immuno-oncology
Insilico Medicine's Chemistry42 platform enables the efficient discovery of a potent, oral CBLB inhibitor with low toxicity risks and favorable ADME/PK profiles. The compound demonstrates strong in vitro activity and improved metabolic stability in mouse, rat, and dog models.
Immunotherapy works for sepsis thanks to smart patient selection
A precision medicine-based approach tailors treatment to each patient's unique immune status, improving disease severity and reducing organ failure. The study reveals a significant improvement in clinical outcomes for patients with specific types of sepsis.
Could altering the daily timing of immunotherapy improve survival in people with cancer?
Researchers found that patients who received immunochemotherapy before 3:00 pm experienced significantly longer progression-free survival and overall survival compared to those treated later. Earlier administration of immunotherapy was also associated with lower risks of cancer progression and death.
‘Ready-made’ T-cell gene therapy tackles ‘incurable’ T-cell leukemia
A new treatment using genome-edited immune cells has shown promising results in helping children and adults fight a rare form of blood cancer called T-cell acute lymphoblastic leukaemia (T-ALL). The gene therapy, known as BE-CAR7, uses base-editing to modify T-cells and destroy cancerous cells.
Lower doses of immunotherapy for skin cancer give better results
A new study by researchers at Karolinska Institutet found that lower doses of approved immunotherapy drugs can give better results against tumours, while reducing side effects. The regimen with the lower dose of ipilimumab was more effective, with a higher proportion of patients responding to treatment and longer overall survival.
Long-term HIV control: Could this combination therapy be the key?
A new combination therapy approach enabled seven out of ten participants to keep the virus at low levels for many months after going off antiretroviral therapy. The results suggest a possible cure for HIV and offer a proof of concept that this approach could work.
Study: New protocol for Treg expansion uses targeted immunotherapy to reduce transplant complications
A new protocol for Treg expansion uses targeted immunotherapy to reduce transplant complications, boosting survival rates while preserving anti-cancer immunity. The protocol, led by Robert Levy, uses TL1A-Ig fusion protein and low-dose IL-2 to stimulate specific receptors on Tregs, promoting a safer environment for stem cell transplants.
Breakthrough in cancer immunotherapy using marine bacteria
Researchers discovered P. angustum selectively targets colorectal cancer, inducing direct tumor lysis and robust immune activation. The therapy promotes intratumoral infiltration of immune cells and enhances production of inflammatory cytokines, significantly prolonging survival in treated mice.
A ‘magic bullet’ for polycystic kidney disease in the making
Researchers at UC Santa Barbara propose a cyst-targeted therapy using monoclonal antibodies to interrupt the runaway growth of fluid-filled sacs in polycystic kidney disease. The treatment, targeting a driver of cyst progression, shows promise in slowing or reversing the disease with minimal side effects.
Targeting the matrix for anti-tumor T cell revival
Researchers have identified a protein complex that drives T cell exhaustion in tumors and show that disrupting it can revive exhausted anti-tumor CTLs. The study's findings offer new hope for improving the efficacy of cancer immunotherapy.
Nasal therapeutic vaccine for treating cervical cancer
Researchers at Chiba University have developed a nasal therapeutic vaccine targeting E7 oncoprotein, which is produced by high-risk strains of HPV associated with cervical cancer. The vaccine triggers an immune response in the cervical mucosa, providing local protection against pathogens and foreign particles.
University of Ottawa medical scientist leads pioneering cancer immunotherapy research with $3 million grant
A team of researchers led by Dr. Michele Ardolino is bridging scientific fields to unlock the mechanisms behind effective immune responses in cancer patients. They will study the interactions between the immune system, nervous system, and gut microbiome to design more personalized treatment strategies.
Synergistic ferroptosis–immunotherapy nanoplatforms: Multidimensional engineering for tumor microenvironment remodeling and therapeutic optimization
Researchers have presented a comprehensive review on synergistic ferroptosis–immunotherapy nanoplatforms to overcome TME resistance and enhance antitumor immunity. The work offers a systematic roadmap for integrating ferroptosis induction with immunotherapy.
Colorectal cancer evades immunotherapy using a dual barrier
A study reveals how colorectal tumors use TGF-β to prevent immune cells from reaching and attacking the tumor. The researchers suggest strategies to improve immunotherapy efficacy by blocking this dual barrier and identifying new therapeutic targets.
MD Anderson experts spotlight key immunotherapy advances at 2025 SITC Annual Meeting
Researchers at MD Anderson Cancer Center are sharing new insights on training the immune system to improve patient outcomes. Key findings include the potential of gut microbiome manipulation in improving immunotherapy responses and developing novel treatments for patients with EGFR-positive lung cancer.
Moffitt study reveals way to spark immune hotspots that attack tumors
A new biomaterial platform induces local accumulation of immune cells, forming structures similar to those found in tumors. This model could lead to therapies that stimulate TLS formation and boost antitumor immunity.
Inflammation may be responsible for driving earliest stages of lung cancer
Researchers at University of Texas M. D. Anderson Cancer Center discover that inflammation is responsible for driving the earliest stages of lung cancer, identifying potential targets for early intervention and suggesting a promising approach to intercepting lung cancer development.
Protective microglia subtype offers potential new therapeutic pathway in Alzheimer’s disease
Researchers have identified a distinct population of neuroprotective microglia that may point to a new therapeutic approach for Alzheimer's disease. Microglia with reduced expression of PU.1 and co-expression of CD28 limit neuroinflammation and slow amyloid plaque build-up.
Protective microglia subtype offers potential new therapeutic pathway in Alzheimer’s disease
Researchers identified a PU.1-promoting subset of microglia that suppresses inflammation and protects cognitive function in mice with Alzheimer's disease. This discovery opens a new avenue for immunotherapies targeting microglial activity.
Turning on an immune pathway in tumors could lead to their destruction
MIT researchers use messenger RNA to activate an immune pathway in nearby immune cells, triggering the destruction of tumors. The approach combines existing immunotherapy drugs and avoids side effects associated with large doses of STING activators.
New antibody therapy reawakens immune system to fight pancreatic cancer
Researchers at Northwestern University have discovered how pancreatic tumors evade the immune system and created an antibody therapy that blocks this mechanism, reawakening immune cells to attack cancer cells. The study shows promise for treating pancreatic cancer and may have broader implications for other hard-to-treat cancers.
From blood to solid tumors: A new way to power up CAR T cell therapy
Researchers at Monash University have developed a new strategy to improve CAR T cell therapy for solid tumors. By targeting the PTPN2 protein, they enhanced the efficacy of CAR T cells and generated long-lived memory T cells that can persist in circulation.
DNA copy-number changes help melanoma develop resistance to immunotherapy, UCLA study finds
A UCLA study finds that DNA copy-number changes enable melanoma cells to resist immune attacks, leading to tumor relapse. The researchers suggest a strategy to make tumors more prone to self-destruction after immune attacks, potentially extending the effectiveness of immunotherapy.
RNA modification m⁶A emerges as key player in cancer development and therapy
Research suggests m⁶A modification regulates oncogenic pathways, immune evasion, and metabolic reprogramming in cancer. Dysregulation of m⁶A drives cancer hallmarks like uncontrolled proliferation and metastasis.
Mayo Clinic researchers find enhancing the body’s ‘first responder’ cells may boost immune therapy for cancer
Researchers at Mayo Clinic have found a way to enhance the body's 'first responder' cells, which can boost standard immunotherapies for cancer. By targeting these myeloid cells, it may be possible to improve treatments that interfere with immune suppressive proteins PD-1 and PD-L1.
Custom-designed receptors boost cancer-fighting T cells
Researchers developed a computational platform to design synthetic protein receptors that can detect tumor signals and boost T cell activity. The new receptors, called T-SenSERs, showed improved tumor control and longer survival in mouse models of lung cancer and multiple myeloma.
Allison Institute’s third annual scientific symposium highlighted by panel discussion with five Nobel laureates
The Allison Institute's third annual scientific symposium featured a panel discussion with five Nobel laureates, highlighting breakthroughs in cancer vaccines, immunotherapy, and immunology research. The event also recognized scientific achievement and leadership through award presentations.
New Alliance trial studies targeted therapies for rare adrenal cancers
A new Alliance trial is exploring the effectiveness of a combination of targeted therapy and immunotherapy for patients with advanced adrenocortical carcinoma, a rare and aggressive cancer. The study aims to improve disease control and quality of life for patients with limited treatment options.
UCLA scientists develop one-product-fits-all immunotherapy for breast cancer
Researchers at UCLA have developed CAR-NKT cell therapy, which can attack tumors from multiple fronts while dismantling their protective shields. The therapy uses engineered immune cells that can be mass-produced from donated blood stem cells and stored ready-to-use, offering a potentially life-changing treatment option.
Immunotherapy after surgery shows potential in preventing the spread of aggressive skin cancer
A new clinical trial by ECOG-ACRIN Cancer Research Group found pembrolizumab reduced cancer recurrence risk to 73% in patients receiving the treatment after surgery. Patients also showed a 42% lower risk of developing distant metastases.