Leukocytes
Articles tagged with Leukocytes
Sauna bathing may boost immune responses
C-reactive protein is closely related to cardiac repolarization in patients with coronary artery disease in contrast to patients with cirrhosis
A new study reveals that C-reactive protein is associated with ventricular arrhythmias in stable coronary disease, while its relationship with heart rhythms is different in patients with cirrhosis. In cirrhosis, only high white blood cell count shows a trend for linking to unstable rhythms.
Chinese Neurosurgical Journal highlights eosinophils as a potential target in chordoma treatment
Researchers found that eosinophils suppress chordoma growth and induce cell death in tumor cells, suggesting them as a novel immunotherapeutic target. The study's findings provide new insight into the immune mechanisms underlying chordoma progression.
Discrimination linked to diminished immune system function
Researchers found that people experiencing everyday discrimination have elevated levels of "exhausted" white blood cells, indicating chronic stress may hamper the immune system. This study suggests social experiences like discrimination shape immune health at the cellular level and contribute to biological aging.
Cat disease challenges what scientists thought about coronaviruses
Researchers have discovered that feline infectious peritonitis virus infects a broader range of immune cells, including B lymphocytes and T lymphocytes. The findings suggest that the virus can persist in these cells even after treatment, potentially leading to long-term immune problems.
Night shifts aren’t just tiring, they can be deadly
A new study from Texas A&M University reveals that circadian disruptions change the structure of mammary glands, weaken immune defenses, and fuel aggressive breast cancer. Disabling an immune checkpoint molecule called LILRB4 helps restore the immune system's ability to fight back.
Rejuvenating the blood: A new pharmacological strategy targeting RhoA in haematopoietic stem cells
Researchers develop ex vivo treatment of blood stem cells with Rhosin, a RhoA inhibitor, to rejuvenate them and improve the production of healthy blood cells. This strategy targets the core of the ageing process, making blood stem cells more capable of regenerating and producing new healthy blood cells.
Insight into how sugars regulate the inflammatory disease process
Scientists have discovered that immune cells shed their glycocalyx layer to move into tissues, changing the understanding of inflammatory skin diseases like psoriasis. This finding may lead to new approaches in developing drugs targeting immune cell movement and treating infections and inflammatory diseases.
Heat as a turbo-boost for immune cells
Researchers discover that temperature affects immune cell movement and efficiency, with Myosin II playing a key role in regulating cellular thermo-adaptability. The study finds that increased temperature leads to faster immune cell migration and a higher number of cells entering lymphatic vessels.
‘Molecular shield’ placed in the nose may soon treat common hay fever trigger
Researchers have engineered a monoclonal antibody that blocks allergic reactions against common pollen when applied inside the nose of mice, providing new hope for hay fever sufferers. The treatment, known as a 'molecular shield,' acts immediately and locally at the lining of the nose to prevent IgE antibodies from being activated.
Researchers create chemotaxic biomimetic liquid metallic leukocytes with versatile behavior
The researchers created a chemotaxic biomimetic liquid metallic entity that exhibits various behaviors like engulfing foreign substances and changing shape, similar to living cells. These liquid metal structures can autonomously climb slopes and move through complicated surfaces with versatility and potential for future applications.
Terasaki Institute researchers develop promising nanoparticle-based approach to obesity treatment
Researchers at Terasaki Institute have developed simvastatin-loaded nanoparticles to target adipose tissue inflammation, promoting fat tissue browning and weight loss. The treatment effectively inhibits obesity-related inflammation, controlled white fat production, and demonstrated strong anti-inflammatory effects.
Leukocyte telomere length and disease severity in cystic fibrosis
A new study found that cystic fibrosis patients with more severe disease characteristics exhibit shorter leukocyte telomere length and greater LTL attrition. This association may accelerate aging and increase susceptibility to age-related diseases, emphasizing the importance of early CF diagnosis and timely therapeutic intervention.
Scientists discover how the body's killer cells attack cancer
Researchers have found that natural killer cells instinctively recognize and attack the XPO1 protein, which drives cancer growth. By targeting this protein, scientists may be able to activate more killer cells to destroy cancer cells. The study suggests that this approach could lead to personalized cancer treatment with less side effects.
Association between osteoporosis and telomere shortening
Researchers found that osteoporosis is independently associated with rapid leukocyte telomere length shortening over a 2-year period. A total of 233 subjects were enrolled in the study, and multivariable linear regression analysis indicated that only osteoporosis was significantly linked to LTL shortening.
Scientists discover new T cells and genes related to immune disorders
Researchers have discovered several rare types of helper T cells associated with immune disorders such as multiple sclerosis and rheumatoid arthritis. The study found that genetic variants in bidirectional enhancer DNA are linked to specific immune-mediated diseases, including inflammatory bowel disease.
Interferon-beta regulates excessive alternative splicing in multiple sclerosis
A new study found extensive alternative splicing of messenger RNA in untreated multiple sclerosis patients compared to healthy controls. Interferon-ß therapy corrected dysregulated alternative splicing, linking it to future clinical exacerbations.
Possible trigger for autoimmune diseases discovered: B cells teach T cells which targets must not be attacked
Researchers have discovered a previously unknown mechanism behind immune tolerance, where B cells teach T cells to ignore the body's own proteins. This failure can lead to autoimmune diseases such as Multiple Sclerosis-like Neuromyelitis optica.
New study uncovers molecular interactions driving multiple inflammasome activation and inflammatory cell death
A team of researchers discovered a multiprotein complex involving NLRP3, AIM2, NLRC4, and Pyrin that drives PANoptosis, a type of programmed inflammatory cell death. The findings have implications for understanding inflammasome biology and identifying potential therapeutic targets.
Short telomeres in alveolar type II cells associate with lung fibrosis in post COVID-19 patients with cancer
Researchers found a link between short telomeres in ATII cells and lung fibrosis in post-COVID-19 patients. The study revealed loss of ATII cellularity and shorter telomeres concomitant with increased fibrotic lung parenchyma remodeling.
Pre-basophils: A basophil origin story
Researchers from Tokyo Medical and Dental University have identified a previously unknown intermediate cell type, pre-basophils, which plays a critical role in the differentiation of precursor cells into mature basophils. These newly discovered cells exhibit higher proliferation capacity and distinct surface protein expression profiles...
Clues found regarding tumor suppressor gene’s breast cancer activity
A new study reveals that HOXA5 binds to protein IκB-α, boosting its cancer-suppressing properties and reducing the development of breast cancers. The presence of HOXA5 suppresses malignancy in breast epithelial cells by blunting NF-κB action.
Genetic discovery to improve lung cancer treatment
Researchers at Edith Cowan University have found a genetic link between human leukocyte antigens and immunotherapy side effects in non-small cell lung cancer patients. The discovery enables doctors to tailor treatment to individual patients, reducing the risk of toxicities and improving overall outcomes.
New analysis approach could increase the number of usable donor kidneys
Researchers developed a new SERS-based multiplexing technique to detect kidney injury biomarkers SLPI and IL-18, achieving high sensitivity and reliability. The approach shows promise for objectively assessing donor kidney quality, potentially reducing discard rates and recipient complications in clinical practice.
A stunning 3D map of blood vessels and cells in a mouse skull could help scientists make new bones
Johns Hopkins Medicine researchers have developed a 3D map of blood vessels and stem cells in a mouse skull, revealing previously unknown niches for stem cell residence. The map provides precise locations of blood vessels and stem cells, which could be used to repair wounds and generate new bone tissue.
Discovery of new role for the brain’s immune cells could have Alzheimer's implications
Microglia play a vital support role in maintaining blood vessels in the brain, regulating blood flow and capillary diameter. This discovery may lead to new therapies for diseases affecting small brain vessels, such as Alzheimer's and stroke.
Scientists identify protein markers related to the most common form of leukemia
Researchers have discovered protein markers related to chronic lymphocytic leukemia (CLL), a common form of leukemia. The markers can help determine patients' prognoses and point to potential therapeutic targets.
Observations indicate strengthening of tropical Pacific western boundary currents for six decades
Recent study reveals significant strengthening of tropical Pacific western boundary currents (WBCs) over the past six decades, primarily driven by temperature change. The WBCs' intensification is attributed to a strengthening of trade winds in the western Pacific Ocean.
Polysaccharides from red algae affect mice immune systems, say FEFU scientists
Researchers found that red algae polysaccharides can suppress the activity of immune cells in lab mice, reducing leukocyte count and congenital immunity cell activity. However, it is unclear whether this effect is beneficial or detrimental, and further study is needed to understand its potential as a pharmacological substance.
In the lab, St. Jude scientists identify possible COVID-19 treatment
Researchers discovered a potential strategy to prevent life-threatening inflammation, lung damage, and organ failure in patients with COVID-19. They identified specific cytokines that trigger inflammatory cell death pathways, leading to tissue damage and multi-organ failure. Treatment using existing drugs targeting these cytokines show...
How the enzyme lipoxygenase drives heart failure after heart attacks
A recent study by Dr. Ganesh Halade and colleagues found that lipoxygenase deficiency delays heart failure progression and improves survival in mice. The researchers discovered that epoxyeicosatrienoic acids facilitate cardiac healing after a heart attack, reducing diabetes risk biomarkers and altering plasma metabolic signaling.
Blood leukocytes mirror insufficient sleep
A study by the University of Helsinki found that insufficient sleep is associated with changes in DNA methylation in gene regulatory elements related to the nervous system development pathway. This indicates a potential link between chronic sleep deprivation and long-term health risks.
Assaying circulating tumor cells
A study describes a microfluidic system to concentrate and encapsulate circulating tumor cells, which are cancer cells that can travel through the bloodstream. Experiments with prostate cancer cells revealed high matrix metalloprotease enzyme activity.
Potent new mechanism of action for treatment of inflammatory bowel disease revealed
A novel mechanism of action has been identified for the treatment of inflammatory bowel disease, showing promise for a new therapeutic approach. The study discovered that an orally active small molecule, ER-464195-01, suppresses leukocyte adhesion by binding to calreticulin and inhibiting integrin activation.
Psoriasis treated with compound derived from immune cells
A compound derived from immune cells has been found to treat psoriasis in mice, with the potential to be effective against other autoimmune diseases such as multiple sclerosis and rheumatoid arthritis. The study suggests that the compound suppresses an inflammatory pathway that is overactive in these conditions.
Scientists create unique disease 'catalog' linked to immune system gene variations
A comprehensive catalog of diseases associated with human leukocyte antigen (HLA) gene variations has been generated by researchers at Vanderbilt University Medical Center. The catalog identifies individuals at risk for certain autoimmune diseases and potential new associations with multiple sclerosis and cervical cancer.
Deciphering an embryo-protecting protein
A team of researchers at Hokkaido University has uncovered the structure of a protein called HLA-G2 that protects embryos from being attacked by their mothers' immune systems during pregnancy. The structure was found to be similar to another class of human leukocyte antigens, suggesting its evolutionary origin.
Study reveals surprises concerning COPD and smoking
A new study reveals a significant decrease in airway wall cells and certain inflammatory cells in smokers and mild to moderate COPD patients. The findings challenge the widely accepted description of airway inflammation in these individuals, suggesting a more complex underlying mechanism.
New PET radiotracer identifies inflammation in life-threatening atherosclerosis
Researchers develop a new PET radiotracer that can quickly identify life-threatening atherosclerotic plaques by detecting inflammation. This breakthrough has the potential to prevent heart attacks and strokes by allowing for early treatment of atherosclerosis.
Cardiovascular health linked to cellular aging
Researchers found that shorter leukocyte telomere length is associated with poorer cardiovascular health and reflects cardiovascular health more accurately in women and white people. The study used data from the National Health and Nutrition Examination Survey to measure telomere length and overall cardiovascular health in 5,194 subjects.
Encapsulated human islet cells can normalize blood sugar levels in mice
Scientists successfully implanted encapsulated insulin-producing human stem cell-derived islet cells into mouse models of diabetes, maintaining long-term blood glucose control without immunosuppression. The study uses chemically-tweaked gel capsules that resist scar tissue buildup, a major hurdle in previous research.
MARC travel awards announced for: Society of Leukocyte Biology 2014 Joint Meeting
The FASEB MARC Program has announced travel award recipients for the Society of Leukocyte Biology Joint Meeting. This year, 1 student and postdoctoral researcher received a total of $1,850 to encourage participation from underrepresented groups in biomedical research.
Researchers identify novel approach to create red blood cells, platelets in vitro
A novel approach to create human red blood cells and platelets in vitro has been identified by researchers at Boston University School of Medicine. This finding could potentially reduce the need for blood donations, speed up research on therapies to treat diseases such as sickle cell disease.
Endothelium, heal thyself
The endothelium, a cellular layer lining blood vessels, has an efficient barrier function maintained by its ability to heal micro-wounds. New research shows that biomechanical signals trigger the recovery response, generating reactive oxygen species to close gaps and restore functionality.
Scientists refute Greenpeace claim that genetically modified corn caused new insect pest
The JIPM authors refute Greenpeace's claim that genetically modified corn caused the western bean cutworm to spread. Instead, they cite various ecological and agronomic factors, such as conservation tillage, reduced insecticide use, and climate change, which may have contributed to the WBC's range expansion.
Changes in gene expression may be responsible for clinical complications following major trauma
A study found that gene expression changes in some patients following major trauma can lead to severe inflammatory complications. Researchers used DNA microarrays to analyze blood samples and identified genes associated with long-term outcomes. This discovery could help scientists develop new drug targets to prevent such complications.
MARC Travel Awards announced for the 2011 Society for Leukocyte Biology Meeting
The FASEB MARC Program has selected three travel award recipients to promote diversity in the basic science community and encourage young scientists at the 2011 SLB Meeting. The awards totaled $4,950 and aim to increase competitiveness of underrepresented minorities engaged in biomedical research.
MARC Travel Awards announced for the 2010 Society for Leukocyte Biology Meeting
The FASEB MARC Program has awarded $18,500 to Ashley S. Triplett from the University of Louisville for participation at the 2010 SLB Meeting, aiming to increase underrepresented minorities in biomedical research. The program, funded by the National Institute of General Medical Sciences, supports young scientists and postdoctorates.
Length of biological marker associated with risk of cancer
A new study reveals that shorter leukocyte telomere length is associated with a significantly increased risk of developing cancer and dying from cancer. Participants with the shortest telomere lengths had approximately three times the risk of cancer compared to those in the longest group.
Reflux esophagitis due to immune reaction, not acute acid burn
Researchers found that gastroesophageal reflux disease spurs cytokine release, attracting inflammatory cells to the esophagus. This leads to damage characteristic of GERD, including symptoms like heartburn and chest pain.
Phase of clock gene expression in human leukocytes correlates with habitual sleep timing
Research reveals a correlation between the phase of clock gene expression and habitual sleep timing, suggesting a peripheral circadian clock's role in regulating hormone rhythms and sleep-wake cycles. The study's findings provide new insights into the relationship between genetic markers and sleep disorders.
Blood clotting protein linked to rheumatoid arthritis
A study by Cincinnati Children's reveals that fibrin plays a crucial role in the inflammatory response and development of rheumatoid arthritis. Researchers suggest that therapies targeting the interaction between fibrin and a specific integrin receptor may help treat arthritis patients.
A little stress gives beneficial oomph! to immune system
Acute stress temporarily mobilizes all major types of immune cells, which may enhance the immune system's ability to protect against infections and diseases. However, chronic stress may weaken the immune system, and excessive stress can worsen pre-existing inflammatory illnesses.
Novel IBD therapeutic approaches reported from Washington Univ., Barcelona, LSU at APS meeting
Researchers present novel therapeutic approaches to treat IBD by targeting adhesion molecules, platelet recruitment, and CTLA-4-Ig. These approaches show promise in reducing intestinal inflammation and promoting tolerance in experimental models.
MMP enzymes play key role in stability and breakdown of atherosclerotic plaques
Researchers have found that MMP enzymes recruit circulating inflammatory cells to form atherosclerotic plaques, which can lead to acute cardiovascular events. The study also reveals the complex roles of MMP enzymes in remodeling the extracellular matrix, suggesting new therapeutic strategies to limit plaque growth.
Stem cell transplants may be effective for MS patients
A new autologous stem cell transplantation treatment has shown promising results in stabilizing the disability of 26 people with severe multiple sclerosis. The study found that 20 patients remained stable, while six showed mild improvement, with only three experiencing new brain lesions at one year after the transplant.