Sjogrens Syndrome
Articles tagged with Sjogrens Syndrome
Extrahepatic autoimmune diseases in autoimmune hepatitis: their prevalence, predictors, and influence on early treatment outcomes
A study of 371 patients with autoimmune hepatitis (AIH) found that extrahepatic autoimmune diseases (EADs) are common, particularly Sjogren's syndrome and autoimmune thyroid disease. Patients with EADs had a poorer early treatment response but achieved comparable outcomes after six months.
New antibodies developed that can inhibit inflammation in autoimmune diseases
Two first-in-class antibodies, C01 and C04, have been developed to inhibit inflammation in autoimmune diseases by blocking the high-affinity IgG receptor FcγRI. The antibodies were discovered using a unique immunization method and exhibit higher affinity for FcγRI than human IgG.
KAIST discovers protein switch that turns anti-viral immune response on and off
Researchers at KAIST have identified a critical protein called SLIRP that acts as an 'immune switch' regulating immune responses to viruses and autoimmune diseases. Suppressing SLIRP can alleviate abnormal immune responses in patients with Sjögren's syndrome, coronavirus, and encephalomyocarditis virus infection.
Autoimmune disease and pregnancy
A study published in Lancet eClinical Health found pregnancy outcomes for pregnant individuals with autoimmune disease vary greatly depending on the specific condition and individual factors. Research highlights the importance of considering comorbidities when discussing autoimmune disease and pregnancy.
‘Off target’ metabolic effects of anti-inflammatory drugs used for autoimmune disorders needs better treatment strategy
A large-scale review of anti-inflammatory drugs used for autoimmune disorders suggests that current treatments can worsen lipid metabolism, leading to increased cardiovascular disease risk. Researchers propose the development of combination therapies targeting lipid metabolism to reduce immune complications and CVD risk in patients.
Complement genes add to sex-based vulnerability in lupus and schizophrenia
Research found that complement gene variants contribute to sex-based differences in vulnerability to autoimmune diseases lupus and Sjögren's syndrome, as well as mental disorder schizophrenia. Complement protein levels vary between men and women, with different age-related elevations and effects on disease incidence.
Hope offered to patients with a rare autoimmune condition
A new study has discovered four subtypes of primary Sjögren's syndrome, a chronic inflammatory disease affecting the body's fluid production. This finding offers hope for personalized treatment and improved quality of life for patients.
Infections linked with an increased risk of developing Sjögren's syndrome
A study of 9,048 individuals in Sweden found that respiratory, skin, and urogenital infections significantly increase the risk of developing Sjögren's syndrome. The findings support the hypothesis that environmental triggers play a crucial role in its development.
Forsyth study provides new insight in the fight against Sjögren's syndrome
Researchers at the Forsyth Institute have defined the immune-regulatory mechanisms of Sjögren's syndrome, revealing how PD-L1 and PD-1 proteins interact to suppress protective immunity. The study found that inhibiting this pathway accelerates autoimmune responses and disease development.
New study to investigate how good antibodies go bad
A new study led by University at Buffalo researcher Jill Kramer aims to re-examine the role of IgM in Sjögren's syndrome. The research seeks to understand whether this protective antibody is also pathogenic, potentially leading to a better understanding of autoimmune diseases.
Females with primary Sjogren's syndrome more likely to experience sexual dysfunction
Women with primary Sjögren's syndrome experience impaired sexual functioning and higher levels of distress compared to healthy controls. Vaginal dryness, pain, fatigue, and depressive symptoms significantly contribute to their symptoms. Healthcare providers should acknowledge and discuss these issues to help patients cope.
Common treatment of certain autoimmune disease does not appear effective
A recent study published in JAMA found that hydroxychloroquine, a commonly prescribed treatment for primary Sjögren syndrome, did not improve symptoms in patients. The 24-week trial involved 120 patients and showed no significant difference between hydroxychloroquine and placebo groups.
Sjögren's Syndrome significantly increases risk of heart attack
A study found that Sjögren's Syndrome significantly increases the risk of heart attack in patients, particularly within the first year following diagnosis. The research highlights the importance of active management of cardiovascular risk factors to reduce the risk of a future heart attack.
Despite burden, Sjögren's syndrome may not impede function
Patients with Sjögren's syndrome report higher levels of cognitive, psychological, and physical impairment than peers, yet still maintain high functional levels. The study suggests that people with Sjögren's can compensate for the disease's effects and function reasonably well.
Autoantibodies found in blood years before symptom onset of autoimmune disease
Researchers found autoantibodies in patients with primary Sjögren syndrome 18-7 years before symptoms appeared. The study's results suggest that autoantibody profiling may help identify individuals at risk of autoimmune disease years before symptom onset.
International coalition of researchers finds 6 new Sjögren's syndrome genes
Researchers have identified six new disease-related genes for Sjögren's syndrome, an autoimmune disease that affects moisture-producing glands. The findings provide a first step towards understanding how genetic variants alter immune system functions and may lead to the development of therapeutics.
2012 AADR Sjogren's Syndrome Foundation Student Fellowship awarded to Collymore
The American Association for Dental Research awarded Page Linae Collymore a $4,000 student fellowship to encourage research on Sjögren's Syndrome. She is a student at Southern Illinois University and will be recognized at the AADR's 41st Annual Meeting in March 2012.
Inability to cry in patients with Sjogrens syndrome affect emotional and mental well-being
A study found that patients with Sjögren's syndrome are more likely to experience difficulty identifying and describing emotions (alexithymia), which is associated with poorer mental wellbeing. The inability to cry may also contribute to this issue, as patients rely on words and facial expressions instead of tears.
Validation of salivary-biomarkers for Sjogren's syndrome detection in US population
Researchers validated three salivary mRNA biomarkers (B2M, GIP2, MNDA) and three protein biomarkers (B2M, SSA, SSB) for detecting Sjogren's syndrome in the US population, expanding clinical utility of existing biomarkers.
Shao wins grant from Research to Prevent Blindness organization for dry eye research
Dr. Hui Shao has received a grant from the Research to Prevent Blindness organization to study Sjogren's syndrome, a chronic autoimmune disease affecting millions of Americans. Her team has discovered a protein called Klk22, which may play a role in the development of the disease.
Green tea may delay onset of type 1 diabetes
Researchers found that green tea's EGCG reduced salivary gland damage and delayed insulin-dependent type 1 diabetes in a laboratory mouse. The study also showed that EGCG suppressed abnormal gene expression and lowered serum autoantibodies, reducing Sjogren's syndrome-like symptoms.
Green tea may help prevent autoimmune diseases
Researchers found significantly less salivary gland damage in a group treated with green tea extract, suggesting a reduction of Sjogren's Syndrome symptoms like dry mouth. Green tea's EGCG component may also suppress inflammation and turn on the body's defense system against TNF-alpha.
Gene-altered mouse is model for rare autoimmune syndrome
Researchers developed a genetically altered mouse model for Sjögren's syndrome, a rare autoimmune disorder affecting 0.6 percent of the population. The Id3-deficient mice exhibited reduced tear and saliva secretion, lymphocyte infiltration, and autoantibody production, mirroring human disease characteristics.
Researchers identify candidate vaccine for Sjögren syndrome
A team of researchers at the University of Toronto has identified a protein and developed a prototype vaccine that shows promise in treating Sjögren syndrome. The vaccine was able to stop disease progression even after the condition had fully developed.