Articles tagged with Adaptor Proteins
Researchers at PSI have developed a platform to measure biased signalling in G protein-coupled receptors (GPCRs), enabling selective therapeutic effects and fewer side effects. By testing specially designed bivalent ligands, they can bias signalling towards desired pathways.
Scientists have identified a molecular mechanism that enables amphibians and fish to change their color by communicating between the actin and microtubule networks. The discovery reveals potential evolutionary paths and highlights the importance of motor proteins adapting to different cytoskeleton systems.
Researchers identified a molecular mechanism for communication between microtubule and actin networks, enabling color change in amphibians and fish. A theoretical model supports the findings, highlighting the regulatory efficiency of cytoskeletal interactions.
Researchers have identified a novel role for the adaptor protein p66shc in regulating glucose metabolism, suggesting its potential as a therapeutic target for cancer and diabetes. Silencing p66shc enhances glucose metabolism and cell growth, indicating it may act as an energy sensor that responds to nutrient availability.
Researchers have discovered two independent pathways for mRNA export from the nucleus, revealing the role of adapter proteins in regulating this process. The study used cell-permeable peptides to selectively block the action of these proteins, demonstrating their importance in transporting mRNAs for early response genes.