Articles tagged with Ancient Proteins
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Researchers have identified two proteins in birds that compensate for the loss of a key immune component in humans, providing insights into combating respiratory diseases. The study sheds light on how birds maintain lung protection despite their unique respiratory anatomy.
Penghu 1, discovered on the seabed of the Penghu Channel in Taiwan, is revealed to be a Denisovan mandible dating back to 10,000 years ago. The fossil's molecular identification sheds light on the mysterious distribution and appearance of Denisovans in eastern Asia.
Researchers identified critical proteins involved in animal stem cell regulation, including SOX and POU transcription factors, which existed in single-celled organisms over 700 million years ago. These ancient proteins retained functional properties that enabled them to induce stem cell reprogramming in mouse cells.
A new study uses nanoscopic 3-D imaging to analyze ancient bone samples, revealing insights into protein and tissue preservation during fossilization. The technique shows that Ice Age bones still retain original collagen protein frameworks, offering a potential proxy for screening specimen suitability for molecular sequencing.
Researchers have identified an ancient protein that partners with a modern plant enzyme to synthesize lignin, a key component of plant cell walls. This discovery provides insights into the evolution of plant protective mechanisms and their potential industrial applications.
Scientists from OIST created synthetic droplets to mimic biological processes, finding that pH gradients facilitate Marangoni effect and enabling droplets to detect and migrate towards each other. This study sheds light on the movement of simplest forms of life in primordial soup billions of years ago.
New research reveals similarities between dinosaurs and birds in terms of protein composition in their feathers. Analysis of fossil feathers from Sinornithosaurus and Confuciusornis showed beta-proteins, similar to those found in modern bird feathers.
Researchers found stable antibodies in 800-year-old medieval human teeth that can still recognize viral proteins, allowing them to study the history of infectious human diseases. This discovery expands the field of palaeoproteomics and may enable experts to analyze how human antibody responses developed over time.
Scientists at Tohoku University found that boric acid catalyzes polypeptide synthesis under neutral and acidic conditions, producing up to 39 monomer-long glycine polypeptides. This discovery challenges previous studies suggesting neutral conditions hinder peptide synthesis.
A new study reveals that dairy was a key component of early human diets on the Tibetan Plateau, consumed by diverse populations including females and males. Dairying supported prehistoric occupation of the highland region, allowing humans to thrive in extreme environments.
Researchers at Linköping University found that C-reactive protein has a beneficial function in systemic lupus erythematosus, reducing interferon activity and promoting milder disease. The study's findings suggest new treatment strategies to reduce immune complexes and elevated interferon levels.
Researchers at Max Planck Institute successfully revived ancient enzymes, revealing a novel protein component that increased CO2 specificity in Rubisco. This discovery provides new insights into the evolution of modern photosynthesis and suggests adding new components may improve its efficiency.
Researchers analyzed ancient proteins in high-status Viking graves to identify beaver fur, supporting the idea that it was a luxury item. The discovery suggests that wearing exotic fur was an obvious visual statement of affluence and social status during the Viking Age.
A team of researchers has identified the ancient bird species behind giant prehistoric eggs in Australia, resolving a years-long debate. The study found that the eggs belonged to a unique duck-like line of megafauna known as the 'Demon Ducks of Doom', which was laid by the Genyornis newtoni bird.
A team of scientists has confirmed that the earliest humans in Australia consumed eggs from a two-metre tall bird called Genyornis, which became extinct 47,000 years ago. The ancient proteins found in eggshell fragments provide conclusive evidence for this species.
A new study reveals that most mutations in biologically essential genes change steadily and randomly across 700 million years of evolution. This constant drift makes it impossible to reliably predict the effects of most mutations into the future or back into the past.
A new protein called NDF has been discovered to enhance gene activation and may be involved in diseases like cancer. Found in all human tissues, NDF works by stimulating RNA polymerase elongation, a key step in gene expression.
Scientists studying fossilized dinosaur eggshells from Mexico have identified nine amino acids and evidence of ancient protein structures, providing insights into the early lives of these creatures. The analysis also sheds light on the fossilization processes and the role of minerals in preserving organic compounds.
Scientists at Uppsala University resurrected 3.3 billion-year-old bacterial proteins to study their properties and evolutionary history. The researchers found that these ancient proteins had broader specificities than modern counterparts and could function with various types of ribosomes.
A team of researchers has found evidence that people in the Levant were eating turmeric, bananas, and soy in the Bronze and Early Iron Ages, tracing back to South and East Asia. Long-distance trade in culinary goods connected distant societies since at least the Bronze Age.
A new study found that proteins become biochemically addicted to complex interactions, even if they serve no purpose. The 'hydrophobic ratchet' mechanism drives the accumulation of useless complexity inside cells.
A team of researchers identified the evolutionary 'missing link' in hemoglobin evolution, revealing that complexity can emerge through simple mechanisms. The study found that just two mutations triggered the emergence of modern hemoglobin's structure and function over 400 million years ago.
Researchers have resurrected ancient forms of two cell division proteins to study their evolution. They found that one protein boosted the activity of the other through allosteric regulation, a mechanism that has become crucial for cells.
Scientists have successfully linked the extinct giant ape, Gigantopithecus blacki, to its closest living relative, the orangutan. Genetic material from a 2-million-year-old fossil was retrieved using ancient protein sequencing, revealing key insights into human evolution.
Researchers from IBE and Globe Institute rebuilt proteins from a 2-million-year-old fossil, clarifying the evolutionary history of hominids. The technique has shed light on the ancient DNA techniques' limitations, allowing for clearer understanding of human and great ape lineage.
Researchers have extracted almost complete sets of proteins from ancient dental enamel, allowing scientists to reconstruct molecular evolution beyond the usual DNA preservation limit. This breakthrough enables scientists to study hundreds of species, including humans, and could revolutionize our understanding of the world's evolution.
Researchers extracted genetic info from a 1.77 million-year-old rhino tooth, revealing an almost complete set of proteins and expanding the possibilities of retrieving reliable genetic information from mammal fossils. This breakthrough could solve long-standing mysteries of ancient animal and human biology.
Researchers have found the earliest direct evidence of milk consumption in human teeth dating back 6,000 years to Neolithic Britain. The discovery suggests that dairy products were a widespread dietary practice among ancient farmers.
Researchers reverse-engineered a primordial protein and inserted it into a living bacterium, successfully powering its metabolism, growth, and reproduction. The discovery sheds light on the origins of metabolism and has implications for synthetic biology and bioelectronics.
Scientists can now study ancient proteins to gain a more complete picture of past species and cultures. Research has revealed that ancient humans consumed grains, legumes, dairy products and meat, while Mongolians consumed dairy products long before known genetic mutations for lactose tolerance.
Researchers from Boston University School of Medicine have discovered a previously unknown role of Serum Amyloid A (SAA) in rapidly removing lipid debris from damaged cells. This process is crucial for tissue healing and survival during acute events such as injury, infection, or inflammation.
Researchers from Skoltech and MIPT analyzed the protein and lipid composition of a Siberian mammoth bone, identifying 98 proteins and 73 lipids. The study provides insights into the mammoth's diet, health, and nervous system development, complementing paleogenomics and paleoproteomics.
A team of researchers from institutions at the leading edge of palaeoproteomics have published guidelines to support good practices in the field and ensure robust, reproducible results. The guide aims to provide consistency to a new field, addressing issues such as data reporting standards, authentication measures, and lab contamination.
A team of scientists at the University of Arizona has discovered that a newly evolved yeast protein can fold into a compact three-dimensional structure, contrary to the long-held assumption that such proteins are incomplete and 'works-in-progress',
Researchers discovered over 800 alternative ways evolution could have led to the protein's new function, highlighting chance mutations' role. The study reveals how idiosyncratic evolution unfolded, with many possible mutations occurring before reaching the historical solution.
Researchers successfully resurrected Precambrian β-lactamases to study the emergence of primordial enzymes and explore the creation of novel active sites. The team demonstrated that ancestral protein resurrection enables the generation of new enzyme functions, overcoming current limitations in molecular biology.
Researchers have successfully resurrected a four-billion-year-old protein in modern E. coli bacteria, protecting it from viruses. This breakthrough could lead to the development of crop-resistant plants, as the ancient protein can't be hijacked by phages.
Researchers can extract proteins from 80-million-year-old dinosaur bones, providing information on evolution, biomaterials, and potential applications for drug development. The study also explores the age and environment of samples, as well as the functions of ancient proteins.
Researchers studied 15 thioredoxin proteins, including extinct sequences, to understand how they unfold at different temperatures. They found that proteins with similar structure but greater ability to tolerate heat unfold more slowly, making them useful for industrial processes.
Researchers identified an ancient protein mutation that enabled the evolution of a protein necessary for multicellularity in animals. The study, published in eLife, describes a molecular mechanism involved in the origin of complex life and establishes a paradigm for research in evolutionary cell biology.
A study reveals that stress hormone cortisol's inhibitory effects on the immune system may be hundreds of millions of years old. GR, a glucocorticoid receptor, can adopt different shapes to bind DNA, highlighting the importance of protein flexibility in evolving new functions.
A new study reveals a plant protein's role in detecting molecular signals from beneficial fungi, allowing plants to harness essential nutrients and sugars. This symbiotic relationship, prevalent across the plant kingdom, is believed to be crucial to early terrestrial survival and the evolution of life on Earth.
Researchers identify MSL8, a mechanosensitive ion channel, that protects pollen from lethal pressures. The protein helps the hydrating pollen grain relieve excessive pressure and survive the stressful transition.
A Pitt study reveals how ancient proteins like RAD51 paralogues repair damaged DNA and their potential role in tumor development. The findings suggest that targeting these proteins could be a way to tailor cancer therapies.
Researchers have found remarkably preserved 15-million-year-old thin protein sheets in fossil shells from southern Maryland. The proteins share characteristics with modern mollusk shell proteins, offering insights into the evolution of mollusks and the ecology of the Chesapeake Bay during the mid-Miocene era.
Scientists at the Max Planck Institute for Developmental Biology discovered that proteins can be constructed of similar amino acid chains even when their three-dimensional shapes differ significantly. This suggests that modern proteins arose from common precursors, built up from smaller fragments according to a modular principle.
Researchers resurrected an ancient ancestor of a human protein and created millions of alternative histories to test the role of chance events in evolution. They found that two extremely unlikely mutations were necessary for the protein's modern-day function to evolve.
Researchers analyzed aminoacyl tRNA synthetases and found ancient domains linked to dipeptide formation, indicating protein flexibility played a role in genetic code emergence
Protein networks are essential for organisms, and their evolution is a fascinating research question. Researchers have reconstructed ancient protein networks, finding that present-day networks can be explained by the mechanism of duplication and divergence, supporting the interpretation of genome sequence data.
A new study adds giant viruses to the universal family tree, revealing they are ancient living organisms. The research found that many of the most ancient protein folds were also present in giant viruses, suggesting they appeared early in evolution.
Researchers at Yale University have successfully re-engineered the genetic code of bacteria to synthesize special forms of proteins that can mimic natural or disease states. This new technology enables the production of human proteins with their naturally occurring phosphorylation sites, a crucial step in understanding disease processes.
A study reveals that ancient enzymes known as thioredoxin were chemically stable at temperatures up to 32 degrees Celsius higher than their modern counterparts. The enzymes also showed increased activity at lower pH levels, indicating they operated in a hot, acidic environment during early life.
Researchers reconstructed an ancient protein and traced its subtle changes over time to produce diverse modern-day descendants. They found that evolution tweaked the ancestral structure to create partnerships with new hormones or signals, leading to independent proteins with increased stability.
Researchers at Penn State have developed a computational method to trace evolutionary histories of proteins back to cells or viruses, aiming to settle the debate on which came first. The new approach uses phylogenetic profiles and tree-like diagrams to provide clearer insights into retroelement evolution.
Researchers found a motor protein, myosin 2, remains structurally identical in turkeys and scallops despite their different physical paths. This suggests the protein's importance in regulating smooth muscle function, potentially holding key to understanding aneurisms in humans.
Researchers recreated a 450-million-year-old protein using X-ray crystallography and mapped its structure. They found that only seven mutations were needed to evolve the ancient receptor into its modern form, with some 'permissive' changes paving the way for more significant transformations.
Researchers used state-of-the-art techniques to recreate an ancient human protein, tracing its evolution and discovering how it acquired a crucial new function. By analyzing the protein's atomic structure, scientists identified seven key historical mutations that recaptured the protein's present-day response to cortisol.
Researchers created a global family tree of metabolic protein architecture using phylogenetic analysis techniques. The study found that many metabolic protein folds are quite ancient, with some common in all species analyzed, while others are more recent.
Researchers have successfully sequenced tiny pieces of collagen protein from a 68 million-year-old Tyrannosaurus rex fossil, closely matching amino acid sequences found in present-day chickens. The findings support the long-debated proposal that birds and dinosaurs are evolutionarily related.
Biological clocks are reset by slow action of White Collar-1 and White Collar-2 proteins; these proteins work in the dark without light stimulation. Their discovery provides a link between light perception and circadian rhythms, opening an evolutionary window into clock mechanisms.