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Researchers lay groundwork for potential dog-allergy vaccine

Scientists at Osaka Prefecture University have identified specific parts of the dog allergen Can f 1 that can trigger an immune response in people. The researchers used X-ray crystallography to determine the structure of the protein and found several potential epitopes, or regions, that could be targeted by a vaccine.

SourceOsaka Prefecture University·TypeNews article·DateDec 22, 2021
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How to use antibodies to control chemical reactions

Scientists from the University of Rome Tor Vergata created a method to use antibodies to control chemical reactions forming therapeutic agents and imaging molecules. The approach involves modifying synthetic DNA oligonucleotides with recognition elements targeting specific antibodies.

SourceUniversità Roma Tor Vergata·JournalNature Communications·DateDec 7, 2020

Hepatitis B: Natural controllers shed light on immunity mechanisms

Scientists discovered human monoclonal antibodies specific to HBV surface antigens in natural controllers, which showed neutralizing ability and capabilities of blocking viral infection. The findings highlight a promising therapeutic tool for treating chronic HBV infection and may provide an alternative to existing treatments.

SourceInstitut Pasteur·JournalJournal of Experimental Medicine·DateAug 13, 2020
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Antibody test gauges mosquito exposure

Researchers developed a blood test to assess human exposure to Aedes mosquitoes by measuring antibodies against one individual peptide from Aedes saliva. The test showed decreased human exposure to mosquito bites after a vector control program, with 88% of people having a positive antibody reaction before the intervention.

SourcePLOS·JournalPLOS Neglected Tropical Diseases·DateDec 1, 2016

Scientists engineer designer proteins that control enzyme activity

Researchers from the University of Chicago have developed a novel approach to control enzyme activity using monobodies, synthetic proteins that recognize and bind specific target molecules. They successfully altered the specificity of an enzyme used in the food industry without modifying it, paving the way for bespoke reactions.

SourceUniversity of Chicago Medical Center·JournalNature Chemical Biology·DateAug 31, 2015

Dartmouth, GlycoFi researchers make leap in protein bioengineering

GlycoFi researchers have made a major leap in protein bioengineering by controlling sugar structures on antibodies to boost cancer-killing ability. This approach can be applied to any therapeutic glycoprotein, and the company is poised to capitalize on the growing 20% annual growth of the therapeutic protein market.

SourceDartmouth College·JournalNature Biotechnology·DateJan 22, 2006
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