Pennington Biomedical researchers propose a new understanding of how protein restriction promotes healthy aging and extends lifespan by triggering a coordinated whole-body response. The response connects cellular nutrient sensing with hormones, brain function, and changes throughout the body, influencing healthy aging and longevity.
Scientists create a novel nano-delivery system that boosts NAD+ synthesis and reduces consumption, rapidly restoring energy metabolism in damaged kidneys. The approach halts disease progression and prevents chronic kidney disease, offering a promising drug development platform for AKI and other energy metabolism disorders.
A comprehensive study decodes structure-function relationships governing surfactant-mediated enzyme protection, revealing a competitive stabilization mechanism. The research identifies key factors influencing mitigation efficacy, including hydrophobicity and hydrogen bonding capacity, and provides predictive power for designing more ef...
Researchers developed a bioorthogonal fluorescence probe and matching reporter enzyme that selectively activates at targeted tumor sites, enabling high-contrast tumor visualization with minimal background. This technology has potential for improving cancer surgery outcomes and may also be adapted for targeted drug delivery.
A global study by UniSA researchers found that 94% of people who use wearable activity trackers are open to sharing their health information with healthcare providers. This could lead to more personalized and responsive care. The demand for personalized healthcare is on the rise, and wearable activity tracker market is increasing.
Researchers developed a new viscoelastic model of enzymes, elucidating the intertwined effects of elastic forces and friction forces on enzyme function. This breakthrough allows proteins to be perceived as soft robots or programmable active matter, revolutionizing our understanding of enzymatic catalysis.
Researchers developed a sensor platform that tracks multiple metabolites continuously, offering a window into disease onset and health status. The technology harnesses natural biochemical processes, enabling reliable detection of over 800 metabolites, with potential applications in diagnosing metabolic disorders and optimizing fitness.
Researchers at Stanford University have illuminated how enzymes speed up life-sustaining biochemical reactions so dramatically. By understanding the chemical and physical interactions responsible for enzyme's enormous reaction rates, scientists may be able to design new enzymes that rival those found in nature.
Researchers have successfully combined electrocatalysis and biocatalysis to produce methanol from carbon dioxide. The hybrid process uses enzymes to catalyze the final steps, achieving high selectivity and efficiency.
Researchers at King's College London developed a new method to produce biofuels from fatty acids in cooking oil, making it as effective as diesel with improved efficiency. The technology uses enzymes to break down fatty acids into alkenes, reducing the need for conventional catalysts and toxic chemicals.
A team of researchers from the University of Tokyo proposes a new mathematical definition of cell death based on enzymatic reactions and thermodynamics. This definition enables the development of computational methods to quantify the life-death boundary, which could lead to better understanding and control of cellular processes.
The red milkweed beetle's genome has been sequenced, providing insights into how it safely feeds on toxic plants. The study found an apparent expansion of genes related to toxin sequestration and metabolic enzymes.
The team created a new method by adding two different enzymes to the existing reaction, increasing conversion rates from 46% in 7 hours to 80% in 5 hours. This approach also improved fumaric acid production efficiency from 10% to 16%.
A team from the University of Illinois has developed a modeling framework connecting enzyme activity related to photosynthesis to yield. This breakthrough model ties dynamic photosynthetic pathways directly to crop growth for the first time.
Researchers from Tokyo Institute of Technology developed a biocatalyzed carboxylation reaction using Thermoplasma acidophilum malic enzyme to fix CO2, increasing the yield and sustainability of the process. The method can be tailored for selective synthesis of wider carboxylation products, unlocking new avenues for renewable resources.
Researchers at Aarhus University have developed a three-stage process to convert polyethylene (PE) into biodegradable polyester, addressing the issue of plastic waste. The method utilizes enzymes, microorganisms, and chemical processes to break down PE's strong carbon bonds.
Scientists at DTU and Lund University have found new enzymes that can remove both the A and B blood antigens and their blocking sugars, enabling the production of universal donor blood. This breakthrough has the potential to reduce logistics and costs associated with storing four different blood types.
Scripps Research chemists develop a new set of copper-catalyzed reactions for building and modifying pharmaceuticals. The two-mode approach, inspired by human detox enzymes, offers a simple and efficient method for performing dehydrogenations and lactonizations on inexpensive starting compounds.
Researchers discovered a crucial amino acid exchange that enables PsiM to carry out double methylation during evolution. The enzyme plays a key role in psilocybin production, with implications for biotechnological production of the active ingredient.
A new research project, PHOTOZYME, aims to develop photobiocatalytic tools to convert basic chemicals into chiral molecules. The project combines biocatalysis, photochemistry, and directed evolution to create sustainable molecular synthesis.
A team of researchers has determined the detailed mechanism of cyclization catalyzed by the cyclization domain of cyclic β-1,2-glucan synthase from Thermoanaerobacter italicus. The study reveals that the enzyme produces β-glucosidase-resistant compounds and features a transglycosylation reaction.
Researchers have developed a novel imaging method to study the intricate relationships within a fungal garden cultivated by leafcutter ants. The technique revealed crucial metabolites and enzymes driving plant degradation, highlighting the fungus as the primary degrader of plant materials.
Researchers created a network of 4.9 billion plausible chemical reactions using blockchain, shedding light on prebiotic molecules and primitive metabolism. The study also demonstrates how blockchain can be used to solve complex problems in science at a lower cost.
A new catalyst developed by researchers at Nagoya University successfully synthesized a key intermediate for the incontinence drug oxybutynin in 5-30 minutes, significantly faster than existing methods. The discovery represents a major advance in chiral drug synthesis and holds great promise for future drug discovery efforts.
Researchers establish new standards for laboratory experiments to improve PET recycling efficiency. Four engineered enzymes were tested, with LCC-ICCG outperforming the others in terms of depolymerisation rate and enzyme requirement. The study aims to accelerate the development of industrial-scale solutions for PET waste management.
Scientists at NTU Singapore have developed a flexible, human cornea-thin battery that can store electricity from saline solution. The battery could power smart contact lenses with displays and augmented reality capabilities.
Researchers at CABBI develop photoenzymatic system to efficiently synthesize chiral amines, crucial chemical building blocks with wide applications. The team's new method addresses a longstanding challenge in synthetic chemistry and offers a promising platform for biomanufacturing.
Researchers have engineered bacteria to combine natural enzymatic reactions with the carbene transfer reaction, producing new-to-nature carbon products that can be used in biochemicals and advanced biofuels. This breakthrough could reduce industrial emissions by providing sustainable alternatives to chemical manufacturing processes.
Scientists at Duke University found electric fields within biological condensates, which could change the way researchers think about biological chemistry. The discovery suggests that these structures may have played a crucial role in the first life on Earth, providing energy for essential reactions.
Researchers have developed enzymes that can efficiently break down plastic, reducing its environmental impact. However, over-reliance on these technologies may not address the root issue of excessive plastic production.
Edward Chouchani, an associate professor at Harvard Medical School, has been awarded the $50,000 Vilcek Prize for Creative Promise in Biomedical Science. His research focuses on understanding metabolic disease using mass spectrometry and biochemical approaches.
Researchers at Tokyo University of Science used computer simulations to clarify why L-alanine was preferred over D-alanine during primordial RNA aminoacylation reactions. The study revealed that L-amino acid had more electrostatic stability in its transition state, providing a plausible reason for the selective aminoacylation.
Scientists studied F1-ATPase function in bacteria to clarify the angle of rotation during ATP hydrolysis. The study revealed three sets of short and long dwells associated with different intervals per revolution, resolving a long-term debate over the ATP-cleavage shaft angle.
The new homogeneous catalyst enables the direct synthesis of hydrogen peroxide with improved efficiency and safety. The process requires only one step and no separation of gases from the reaction flask.
Scientists have reconstructed the evolutionary history of flavin-containing monooxygenases (FMOs), a class of detoxifying enzymes present in all lifeforms. The study reveals that a single ancestral gene diverged into two distinct functions, with one gene triggering a different breakdown reaction.
A team of scientists developed a simplified and efficient method for artificial production of terpenes, using fluorinated alcohol catalyst solutions. This approach allows targeted production of natural substances from simple starting materials, offering potential applications in food, cosmetics, and pharmaceutical industries.
The EnzymeML format provides a standardized way to record enzymatic experiment results, including conditions, data, kinetic models, and parameters. This enables seamless communication between experimental platforms and promotes reproducibility and trust in scientific results.
Researchers discovered that positively charged micelles can significantly accelerate chemical reactions between like-charged molecules. By controlling the magnitude and spatial distribution of the electric charge on catalysts, reaction rates can be tuned within several orders of magnitude.
Rice University scientists identified a new Diels-Alderase enzyme, CtdP, which catalyzes the Diels-Alder reaction with precise stereochemistry control. This discovery could lead to improved pharmaceutical synthesis and development of more effective drugs.
A germline mutation of topoisomerase II B affects the movement of proteins in the nuclei of cells with this mutation. The study reveals that the mutation impacts nuclear dynamics and provides a platform to understand the biological relevance of such mutations.
Researchers from ETH Zurich elucidated the structure and function of tryptophan C-mannosyltransferase (CMT), a glycosyltransferase enzyme involved in C-mannosylation. The study reveals the enzyme's novel mechanism, enabling precise understanding of protein sequences and sugar substrates.
Researchers have developed a novel hybrid catalyst that combines enzymatic and single-atom catalysis, achieving high efficiency in one-pot chemoenzymatic reactions. This breakthrough simplifies chemical production and separation processes, offering a promising strategy for efficient synthesis of pharmaceutical intermediates.
Scientists at OIST successfully engineered a protein to bind a methylating agent instead of its natural coenzyme. The study uses insertions and deletions to modify the protein's structure, offering insights into coenzyme-protein interactions and potential applications in artificial enzyme design.
A team of researchers has discovered that a reaction sequence from the reverse Krebs cycle can take place without enzymes under metal or meteorite catalysis. The study suggests that simple organic molecules existed on early Earth, even before life as we know it developed.
SourceWiley·JournalAngewandte Chemie International Edition·TypeExperimental study·DateNov 23, 2022
Enzymatic reactions induce phase separation and autoregulation of enzyme activity, creating dynamic environments for cellular processes. This novel mechanism provides an alternative to traditional understanding of cellular organelle function.
Scientists defined the structure of a substrate-bound iron enzyme and found it uses cations to drive desaturation during catalysis. The work could lead to the creation of valuable molecules like vinyl isonitriles with antibiotic properties.
Researchers developed a new enzyme that can degrade poly(ethylene) terephthalate (PET), a common plastic used in bottles. The enzyme, HotPETase, is thermostable and selectively breaks down PET, offering a potential solution to the global plastic waste challenge.
Researchers at KAUST have found that molybdenum plays a central role in electrochemical hydride transfer, a process for producing valuable chemicals or carbon-free fuels. The discovery could enable more sustainable production of sustainable fuels and chemicals.
A team of scientists, led by Dr. Tor Savidge, has proposed a novel mechanism for enzymatic catalytic power, integrating transition state stabilization and ground state destabilization. This new understanding has significant implications for drug design applications and microbial enzymatic catalysis.
A team of scientists at Tokyo University of Science has successfully produced hydrogen peroxide using spent coffee grounds and tea leaf residue. The new method, which is simple, cost-effective, and environmentally friendly, opens up new applications for unused biomass resources.
A team of scientists successfully controlled multistep enzyme reactions using audible sound, creating a new method for spatiotemporal regulation. The researchers used standing waves generated by sound to separate and compartmentalize solutions, allowing for the precise control of chemical reactions.
A team of researchers developed a simple yet powerful strategy for creating new enzymes with novel reactivity that can produce valuable chemical compounds. They used photobiocatalysis to repurpose naturally occurring enzymes and achieved an enantioselective biocatalytic reaction.
A team of researchers discovered a soil microbe's enzyme that performs carbon fixation 20 times faster than plant enzymes. The enzyme consists of pairs of molecules working in sync to get the job done faster. This breakthrough could lead to more efficient artificial photosynthesis and produce fuels, fertilizers, and other products.
A new study reveals that two equal charges in enzymes do not repel each other, but instead attract, facilitating chemical reactions. The researchers used protein crystallography to obtain a structural snapshot of the substrate before the reaction and found an attractive interaction between the enzyme and substrate.
Researchers developed a simple, inexpensive test to detect organophosphate pesticides directly in foods and biological samples. The method uses a new enzymatic cascade reaction called HELP to synthesize luciferin analogues, which produce luminescence in different wavelengths.
SourceWiley·JournalAngewandte Chemie International Edition·TypeExperimental study·DateMar 11, 2022
A team of researchers developed a novel method for producing optically active hydroxy β-lactam derivatives using baker's yeast and microwave irradiation. The process yielded 3:1 ratio of two hydroxyl compounds in 65% yield, with the resulting compounds showing high optical purity.
Researchers have identified a novel enzyme that catalyzes the formation of glycosidic bonds in complex sugar moieties. The discovery provides fresh insights into carbohydrate metabolism and offers a breakthrough for the synthesis of sugar chains, which play key roles in various biological processes.
Scientists have created a 'greener' way to clean wastewater treatment filters by using glucose-based nanoparticles, which effectively remove contaminants without destroying the membrane. The new system is more cost-effective and environmentally friendly than traditional methods.
A new chemoenzymatic cascade reaction has been proposed for sustainable and cost-effective membrane cleaning. The reaction, which combines glucose oxidase and Fe3O4 catalysis, shows improved degradation efficiency compared to traditional Fenton reactions.
A team of researchers identified universal patterns in the chemistry of life that do not appear to depend on specific molecules. They discovered scaling laws between the number of enzymes in different functional classes and an organism's genome size, which don't depend on particular enzymes.