Articles tagged with G Proteins
Researchers at the Center for Genomic Regulation developed a new method to identify new druggable sites on GPCRs, a family of proteins targeted by one in three drugs. This approach enables the creation of detailed functional maps, leading to more precise control of cellular response and reduced unwanted side effects.
A recent study identified a new type of β-1,2-glucan-binding protein in bacteria, which binds cyclic β-1,2-glucans and has implications for understanding bacterial interactions with these complex molecules. The discovery opens up new avenues for developing biological pesticides to protect crops from pathogens.
Researchers at Sanford Burnham Prebys discovered a new mechanism to confer signaling bias in predictable ways, permitting rational design of new drugs. This breakthrough could lead to better therapies for addiction and psychiatric disorders by targeting the neurotensin receptor 1 (NTSR1) with biased modulators.
The study uses cryo-electron microscopy to observe the ETB receptor-G protein complex, revealing a strong binding interaction between G protein and ETB receptor. This finding may deepen understanding of endothelin signaling mechanisms and inform the development of new drugs.