Articles tagged with Glycolytic Pathway
A study identified exosomal microRNA-122-3p as a key driver of MASLD pathogenesis. Elevated miR-122-3p levels induced triglyceride accumulation and reactive oxygen species production in liver cells.
Researchers at the University of Pennsylvania developed lipid nanoparticles that modify immune metabolism to strengthen mRNA vaccines and reduce common side effects. The new lipid boosts the metabolism of immune cells, providing energy for the body's defenses while dialing down inflammatory signals.
Scientists discovered that metabolism plays a signalling role during embryonic development, controlling the tempo of growth. By modulating metabolism, they identified a key metabolite FBP regulating the segmentation clock, which impacts spatial patterns of body segments.
Researchers found that AUF1 helps prevent aging by breaking down enzymes involved in glucose metabolism. The study's findings improve our understanding of how metabolism affects the aging process.
Cancer cells utilize more energy from a less efficient pathway, but researchers found that power-generating waves on the cell membrane could be used to stage cancers and target drugs. Measuring these waves may help stage cancers in a standardized way.
A new study at Stellenbosch University found that blocking the enzymes involved in glycolysis could cut off the malaria parasite's primary energy source and kill it. This approach has shown promise for developing new malaria drugs, particularly against resistant parasites.
Researchers uncover glycolysis' instructive potential in early embryonic development, controlling cell fate decisions and end-state appearance of stem cell-based embryo models. By manipulating glucose concentration, they demonstrate glycolysis' role as an upstream regulator of signalling pathways.
A Japanese research team has discovered a novel global cooperative phenomenon of cell interactions in cervical cancer cells. The framework used in their studies could prove useful for investigating hidden states of a group of cells and may lead to novel cancer therapies.
Scientists at German Cancer Research Center (DKFZ) have found that blocking Aldolase A enzyme can trap energy in liver cancer cells, leading to slowed tumor growth. The team demonstrated this in mouse and human cancer cell lines, suggesting a promising strategy for combating cancer cells.
Researchers at the University of Alabama at Birmingham have identified HIF1α as a key regulator that induces cancer-killing capacity in T cells under hypoxic conditions. In this study, they found that HIF1α-glycolysis is indispensable for IFN-γ induction in hypoxic T cells.
Researchers will investigate how altered copper metabolism and redox balance contribute to endothelial cell dysfunction, leading to cardiovascular diseases. The five-year project aims to understand the underlying mechanisms of vascular disease and develop effective treatments.
Indiana University researchers have found that nicotinamide nucleotide adenylyl transferase 2 (NMNAT2) plays a critical role in protecting the brain from aging and neurodegenerative diseases. The enzyme provides energy to axons, enabling them to carry out nerve impulses and maintain healthy function.
A recent study published in Nature Communications reveals that disrupted NAD(H) homeostasis is a key factor in tuberculosis pathogenesis. The researchers found that the glycolytic pathway can be selectively inhibited using an LDH enzyme with mostly LDHA subunits, which preferentially converts pyruvate to lactate and NADH to NAD+.
Researchers have found that mouse stem cells mimic their parent animals' cold resistance, generating energy differently at low temperatures. This discovery opens up new avenues for studying organ preservation and human hibernation using in vitro models.
A new Northwestern Medicine study has furthered the understanding of metabolic pathways underlying organ development, specifically eye development. The research found that aerobic glycolysis and production of lactate regulate critical genes required for early eye development.
Researchers discovered that FDA-approved HDAC-inhibitors can impact energy metabolism in solid tumor cells, including glioblastoma. The combination of HDAC-inhibitors and imipridones may synergize to enhance killing of GBM cells by reversing cellular respiration.
Researchers at Gladstone Institutes have made a groundbreaking discovery about how neurons consume and metabolize glucose, a process crucial for maintaining normal energy levels. The study found that neurons rely on glycolysis to break down glucose, and its disruption can lead to severe learning and memory problems in mice.
A study suggests that the powerhouse-pruning protein Drp1 plays a crucial role in generating energy for new blood vessel growth, particularly under low oxygen conditions. When oxygen levels are low, Drp1 gets modified to produce reactive oxygen species (ROS), which enables glycolysis and subsequent cell signaling.
Researchers at Massachusetts General Hospital discovered that non-dividing colon cancer cells employ Warburg glycolysis to reduce toxic reactive oxygen species accumulation. This adaptation challenges the long-held dogma of the Warburg effect, highlighting the need for single-cell level analysis tools.
Researchers found that bilobalide, an active ingredient in Ginkgo biloba extract, protects the heart from ischemic injuries by preserving ATP generation and enhancing metabolic flux. The study suggests that bilobalide may provide a new herbal therapy for treating myocardial ischemia.
Researchers found that pyruvate supplementation prevents rapid cell death of peripheral sensory neurons and Schwann cells under high-glucose conditions. Exogenous pyruvate may play a key role in maintaining glycolysis-TCA cycle flux by suppressing PARP activity, thereby supporting cellular viability and energy production.
A team of researchers has developed a combined imaging and machine learning technique that can measure glycolysis in single endothelial cells, revealing a new mechanism of glucose transport. This breakthrough could lead to better treatments for cancer, vascular diseases, and COVID-19.
Scientists have identified new points to calm frenzied energy production in the retina, enabling recovery. The excessive byproducts of glycolysis initiate a vicious loop of crosstalk between endothelial cells and microglia, promoting inflammation and dysfunctional blood vessels.
Researchers found that polyphenol PCB2DG suppresses cytokine production in T cells by inhibiting glycolysis and the mTOR/HIF-1 pathway. This study provides insights into the mechanism underlying the immunosuppressive effects of polyphenols.
Researchers discovered that specific immune T cells from people with ME/CFS exhibit disruptions in energy production, suggesting changes in the immune system. The study found decreased levels of glycolysis and mitochondrial function in affected cells, potentially providing clues to understanding the mechanisms underlying ME/CFS.
A new study finds that women's brains are metabolically three years younger than men's of the same age, which may contribute to their greater mental sharpness in later years. The researchers used PET scans and machine-learning algorithms to measure brain metabolism and calculate each person's brain age.
A new study has identified glycolytic enzymes as potential biomarkers for early detection and prevention of liver cancer. The research found that the shift to glycolysis in cirrhotic livers is associated with a higher risk of developing hepatocellular carcinoma, offering hope for improved early detection and treatment.
A new study by researchers at Washington University School of Medicine found that women with kidney cancer who have substantial abdominal fat are more likely to die within 3 1/2 years after diagnosis, while those with little belly fat tend to live longer. For men, the amount of abdominal fat does not appear to affect survival rates.
Researchers found a connection between abnormal glucose breakdown in the brain and the severity of Alzheimer's symptoms, with lower glycolysis rates and higher brain glucose levels correlated to more severe pathology. The study suggests that targeting glycolysis defects could lead to new treatments for Alzheimer's disease.
Researchers at Kyoto University found that the Myc gene regulates stem cell self-renewal in mice, leading to a slower rate of proliferation and impaired energy production. This discovery may lead to new treatments for infertility by stimulating sperm cell metabolism.
Researchers analyze Cryptosporidium parvum protein involved in energy metabolism, identifying it as a potential target for developing therapeutics. The study found that lactate dehydrogenase inhibitors can inhibit parasite growth and ATP production.
Researchers at Stowers Institute have discovered a protein complex called SESAME that links glycolysis to chromatin modification, suggesting a potential target for detecting and treating cancers. The study's findings may also shed light on the relationship between cellular metabolism and gene expression in humans.
Research reveals that Mdm2 suppresses tumor growth by inhibiting glycolysis through the degradation of PGAM. This process prevents cells from entering senescence and allows them to continue proliferating. The study provides new insights into how damaged cells respond to stress and offers potential avenues for cancer treatment.
Research published in Cell Metabolism reveals that hotspots of fuel consumption in the adult brain are associated with ongoing development and remodeling. The study identifies 16 brain regions with elevated levels of aerobic glycolysis, which is linked to gene expression related to growth, synaptic transmission, and neurogenesis.
Researchers found that certain brain regions exhibit enhanced gene activity levels, similar to those in young brains, allowing for the establishment of new connections. This ability may support lifelong learning and memory formation.
New research reveals targeting blood vessel metabolism may block pathological growth by depriving it of energy and building blocks. Partially blocking PFKFB3 reduces blood vessel sprouting and amplifies VEGF blockade effects, offering a new treatment strategy for conditions like cancer, blindness, and inflammatory diseases.
Researchers at UCLA have created a synthetic metabolic pathway that converts all six glucose carbon atoms into three molecules of acetyl-CoA without losing any as carbon dioxide. This breakthrough could lead to a significant increase in the production of biofuels, with potential applications in biorefineries and photosynthetic microbes.
Researchers found that cancer cells' high sugar consumption disables immune cells' ability to produce inflammatory compounds, making it harder for them to fight tumors. This discovery may lead to new treatments by enhancing T cell function and treating autoimmune disorders.
Researchers discovered that interfering with Hexokinase-2 reduces medulloblastoma's aggressiveness and allows long-term survival in mice. The enzyme plays a key role in aerobic glycolysis, a process also used by rapidly dividing cells, including cancer cells.
A protein regulating glucose processing in cells may also function as a tumor suppressor, according to recent findings. Suppressing glycolysis can halt tumor formation in the absence of this protein.
Researchers identify microRNA-320a as a key regulator of glycolysis in tumors and unused muscles, potentially leading to new treatments for lung cancer and improving ventilator recovery. This discovery offers a significant therapeutic leap for numerous diseases and health conditions.
Scientists at Cornell's Baker Institute of Animal Health have successfully assembled and functioned a human-made device that mimics the biological pathway powering sperm, which could be used to release drugs or perform mechanical functions inside the body. The device uses a nickel-NTA chip to replicate the glycolysis pathway, allowing ...
Scientists discovered a genetic link between glycolysis and DNA replication in Bacillus subtilis, indicating that metabolic signals influence DNA synthesis and stability. This finding suggests a global regulatory function of central carbon metabolism in adjusting cellular functions to nutritional conditions.
A study by Harvard Medical School researchers found that knocking down the glycolytic pathway, specifically LDHA enzyme, effectively shut down glycolysis in breast cancer cells. Eighty percent of mice outlived a four-month experiment with tumor cells lacking this enzyme.
A genetic switch discovered by Hopkins researchers deliberately shuts off a cell's mitochondrial combustion engine under low oxygen conditions. This switch limits the production of toxic oxygen molecules and prevents cellular damage.
A new theory proposes that hyperglycemia and hypoxia contribute to diabetic complications by disrupting NADH recycling. This process produces free radicals that cause damage to tissues, including those in the eyes, heart, nerves, and kidneys. The study suggests that glycolysis and the sorbitol pathway play a crucial role in this process.