Articles tagged with Gtpases
Researchers at UCSF develop a method to target GTPases, enzymes involved in Parkinson's and many other diseases, by using drugs targeting the K-Ras oncogene. This approach reveals new drug binding sites that could not be predicted by computational tools.
In animal models, increasing mTOR activity just slightly accelerates aging and shortens lifetime by up to 20%. This research provides clues on why obesity-related diseases worsen with age. A new model allows researchers to study the relationship between nutrient increase and organ aging.
Researchers found that extracellular vesicles transport RNA molecules between haloarchaea, enabling communication and gene regulation across microbial populations. A small GTPase similar to eukaryotic cells drives this process, suggesting an early evolutionary origin.
A new study develops an algorithm to decode the coordinated regulation of cell-edge velocity by Rho GTPases, revealing specific characteristics of each enzyme. The model predicts edge velocity from activity time series with high accuracy.
Researchers use high-speed atomic force microscopy to visualize the structural dynamics and factor pooling of ribosome stalk proteins, shedding light on the translational GTPase factor mechanism. The study reveals two conformations of the stalk protein and provides evidence for a potential role in further stages of protein synthesis.
Researchers have identified three new genes that play a role in preventing fatty liver development. The genes IRGM, Ifgga2, and Ifgga4 produce regulatory proteins that counteract fat accumulation in the liver, but genetic variations lead to reduced protein production, resulting in increased fat content.
Researchers discovered that GTPases like EF-Tu can exist in a mixture of structures, rather than being fixed as 'on' or 'off'. This flexibility may help develop targeted drugs for bacterial infections and cancer treatment.
Scientists have created an optogenetic process that inhibits intracellular membrane vesicle trafficking, effectively pausing cellular activity. This innovation enables the observation and control of cell membranes, opening up new avenues for studying diseases like neurodegenerative disorders.
A research team discovered an interferon-induced GTPase protein family that destroys bacterial camouflage, allowing cells to recognize and eliminate Salmonella. This finding sheds light on the immune system's strategies against bacterial pathogens.
Researchers found that the ROP18 protein disables host cell proteins that protect against infection, allowing the parasite to thrive. This discovery could lead to new treatments for Toxoplasmosis and other parasitic infections.
Researchers discovered the structure of dynamin, a protein that pinches off tiny pouches from cells' outer membranes, revealing how vesicles form and advancing knowledge of endocytosis. The findings may lead to better ways for delivering drugs.
Biologists have found a critical mechanism in cell division, promoting cytokinesis completion by down-regulating branched microfilaments. The discovery uses roundworms and provides insight into protein interactions and signaling mechanisms.