Articles tagged with Helicases
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
The treatment demonstrated early signals of efficacy, with 65.7% of patients experiencing lasting stable disease, and was generally well-tolerated, with most adverse events being mild and manageable.
Scientists have captured the first detailed molecular movie of DNA being unzipped at the atomic level, revealing how cells copy their genetic material. The discovery has significant implications for understanding viral and cancer replication.
For the first time, scientists have witnessed the moment DNA begins to unravel, revealing a necessary molecular event for DNA replication. This direct observation sheds light on the fundamental mechanisms that allow cells to faithfully duplicate their genetic material.
Researchers discovered Werner syndrome gene WRN plays a crucial role in maintaining constitutive heterochromatin structure, essential for DNA stability. Loss of WRN function disrupts protein interactions, potentially accelerating aging due to cellular disorganization.
A team of researchers has identified the USP50 protein's role in regulating DNA replication by deciding which enzymes to use during critical processes. The study found that USP50 helps cells balance nuclease and helicase activity, preventing replication defects when it is absent.
Researchers found that Werner syndrome mice experience age-dependent and sex-specific changes in their livers and immune systems, including fatty liver accumulation and altered lipid metabolism. These findings suggest a potential link between immunoglobulin variants and fatty liver progression in the disorder.
Researchers have developed a powerful platform to design molecules targeting helicases involved in COVID and certain cancers. The new approach uses electrophilic small molecules to scout out weak points in the enzyme, providing chemical starting points for developing drugs.
Researchers have characterized the functional significance of DDX41 in molecular processes underlying cancer. The study reveals that DDX41 serves crucial functions in transcriptional processes, RNA splicing, and genomic integrity maintenance, which may hold significance in treating hematopoietic malignancies.
Researchers have modelled a key mechanism by which DNA replicates, revealing details about how helicases wrangle DNA during replication. The simulations showed each step of translocation can travel more than 12 nucleotides along the backbone, pinpointing interactions involved in long-distance movement.
Duke researchers identify DDX3X gene as crucial for neuron formation and brain development, with dosage-dependent defects leading to developmental disabilities. The study sheds light on the molecular mechanisms underlying DDX3X syndrome and related disorders, potentially paving the way for therapies.
A recent study published in Aging-US reveals the crucial role of WRN in making choices between classical and alternative non-homologous end joining (NHEJ) DNA repair pathways. The research provides new insights into progeroid syndromes, such as Werner syndrome, and their connection to aging.
Researchers at Arizona State University have developed a new microscopy method that can track 100 single molecules simultaneously in three dimensions. The technique uses surface plasmon resonance (SPR) technology to precisely image molecular binding events and study their dynamic activities in real time.
Researchers used a yeast model to understand the dynamics of early-stage ribosomal subunit assembly, discovering snR190 functions as an RNA chaperone. The study also identified Dbp7 as the enzyme responsible for dissociating snR190 from ribosomal RNA precursors.
Researchers identify nsp13 as a key helicase enzyme in coronaviruses, which could be targeted for COVID-19 treatment and prevention. The study found that nsp13 is a relatively weak helicase requiring assistance to function, providing a potential first line of defense against future coronavirus outbreaks.
Scientists have created glowing probes to visualize four-stranded DNA in living cells, revealing its interaction with molecules and shedding light on its role in cancer and other diseases. The discovery opens up new avenues for research and potential drug development.
A study published in PNAS reveals that DNA helicases unwind the double strand more easily in one direction than the other, with the speed of unwinding depending on the sequence composition of the bases. This discovery has implications for understanding gene expression and the regulation of cellular activities.
Scientists at Johns Hopkins University have unraveled how the DNA machinery fits together, revealing a paradigm shift in understanding genetic illness. The discovery of how nucleosomes change shape to bind with an enzyme could unveil new treatment opportunities for childhood leukemia.
Researchers at Indiana University have identified two enzymes that combine to speed up telomere growth, potentially leading to new ways to treat cancer and premature aging disorders. The study sheds light on the role of helicases in telomere maintenance and may lead to the development of new therapies.
Researchers have gained insight into how the double helix unwinds in the earliest stages of DNA replication. The new cryo-EM images show that the twin helicase enzymes load head to head, forming a complex that positions one strand for extrusion and another as the leading strand.
Scientists at Van Andel Research Institute and collaborators have shed new light on the critical step of DNA replication, revealing a spring-loaded mechanism that positions DNA strands toward two side-way gates. This discovery offers fresh insights into a fundamental process of life and driver of many different diseases, including cancer.
Researchers at University of Southampton discover natural killer cells can recognize global pathogens through a single receptor, paving the way for a new type of vaccine. The study identifies a non-variable part of the virus called the NS3 helicase protein as a key target for the immune system.
The study reveals a left-handed coil structure of the Mcm2-7 hexamer and Cdt1-MCM heptamer, shedding light on DNA unwinding mechanisms. The open-coil structure has profound implications for understanding DNA replication initiation and elongation.
Researchers have mapped the critical steps of DNA replication, revealing how a ring-shaped protein called origin recognition complex (ORC) initiates the process by slipping into a groove on DNA and initiating a cascade of microscopic interactions. The study provides new insights into an immensely complex system that is constantly ongoi...
A new study reveals the structure of DNA helicase at the replication fork, reversing a long-held assumption about its orientation. The findings provide a crucial piece in understanding how life propagates and may lead to new treatments for diseases such as cancers and anemias.
Researchers have solved the mystery of DNA replication by identifying a ring of proteins that binds to origin DNA, causing it to melt and initiate replication. This discovery could lead to understanding genetic duplication and potentially blocking viral pathogens and cancer cells.
Researchers from Tianjin University and Nankai University have unraveled the puzzle of how Zika virus replicates. They discovered a tunnel in the enzyme that holds viral RNA, allowing it to unwind its genetic material. This breakthrough could lead to the development of antiretroviral drugs against this spreading disease.
Cells use programmed fork arrest to halt DNA replication at terminator sites, controlling life span and preserving genome stability. The process involves proteins working together to calibrate fork movement, preventing constant machinery operation.
Scientists have successfully obtained a high-resolution image of the Zika virus helicase, a key target for antiviral development. The structural information will help researchers design and develop effective small-molecule inhibitors to stop viral replication and prevent disease.
Researchers found proofreading molecules apply physical tension to RNA, preventing splicing errors and enabling alternative splicing sites. This mechanism regulates splice site choice, shifting the perspective on the realm of possible activities for this class of enzymes.
Researchers proposed a new mechanism for DNA replication called the 'pumpjack' mechanism, which involves a molecular machine with two distinct conformations that rock back and forth to split the DNA double helix. This linear translocation mechanism appears different from previously thought mechanisms in more primitive organisms.
A team of researchers has revealed the molecular architecture of the replisome, a complex responsible for unwinding and replicating DNA in eukaryotic organisms. The findings show that the replisome has a unique structure, with one polymerase sitting above the helicase, challenging decades-old textbook drawings.
Researchers have produced the first-ever images of the protein complex that unwinds, splits, and copies double-stranded DNA, revealing a counterintuitive architecture. The helicase coordinates with polymerases to duplicate each strand, suggesting potential molecular quality control and developmental biology implications.
Researchers at Florida State University have identified a protein called Treslin that shows promise in stopping the unregulated division of cancer cells. Treslin stimulates the activation of helicase, a key enzyme involved in DNA replication, and assembles it for cell division.
Scientists at the University of Illinois have developed a new lab technique that simultaneously observes protein structure and function in DNA repair. The technique, combining fluorescence microscopy and optical trapping, provides definitive answers to long-debated questions and opens up new avenues for biological engineering.
Researchers pinpoint key moments in the beginning of DNA replication, including structural details about the enzyme that unwinds the DNA double helix. The study's findings offer insights into how the enzyme becomes reactivated to begin its work splitting the DNA.
A team of researchers has identified a unique molecular mechanism involved in DNA duplication during cell division, revealing how a key enzyme governs DNA through a gated system. The study suggests a route for stopping cell division in diseases like cancer by controlling the entry point of the helicase onto DNA.
Researchers have captured a key step in the molecular 'dance' necessary for cell division by imaging the enzyme that unwinds DNA double helices. The study reveals how this enzyme recruits and interacts with the origin recognition complex, enhancing understanding of essential biological processes.
Researchers have discovered a new mechanism of DNA helicase that utilizes thermal motion to move long distances along DNA, providing an energy-efficient way to unwind double-stranded DNA
The National Institute of General Medical Sciences (NIGMS) is honoring its 50th anniversary with a symposium showcasing research advancements in disease diagnosis, treatment, and prevention. NIGMS has funded over 74 Nobel laureates and supports research training programs to foster the next generation of scientists.
Researchers observe helicase enzymes unzipping DNA by manipulating single molecules and observing nucleotide effects. They found ATP can cause unwinding, but only in single-molecule studies.
Researchers discovered that Mtr4p, a RNA helicase, controls the number of adenosines appended to RNAs by TRAMP complex. This tagging is critical for cell function and preservation of normal cell process initiation.
Researchers at the University of Pennsylvania School of Medicine have discovered how telomere caps, made up of G-quadruplexes, protect chromosomes from unraveling. This discovery has implications for studying human aging, Werner syndrome, and Bloom syndrome.
Researchers found that the core protein interacts with non-structural helicase protein, playing a critical role in viral replication. This new understanding supports a potential new therapeutic target for hepatitis C drug development and may prevent production of infectious viral particles.
Researchers have revealed the mechanisms of the DNA-regulating enzyme PcrA, which controls recombination by removing recombination proteins from the DNA. By combining structure-specific binding and motor function, PcrA reels in DNA and kicks off recombination proteins.
Researchers have uncovered the critical action shapshot of an enzyme known as the Rho transcription termination factor, a remarkable class of ring-shaped protein motors. The study reveals a rotary engine-like mechanism that enables the motor to selectively terminate transcription at discrete points along the genome.
Researchers identify HARP, the first motor protein that rewinds defective DNA, preventing gene expression and potentially treating Schimke immuno-osseous dysplasia. The discovery expands our understanding of molecular mechanisms underlying this devastating genetic disorder.
Researchers have solved the XPD protein structure, revealing how small changes in its architecture can cause different diseases. The findings provide novel insight into the processes of aging and cancer.
The researchers studied the archaeal version of Rad3, a unique helicase involved in DNA repair. The findings revealed that the integrity of an iron-sulfur cluster is crucial for proper function of the enzyme.
Research on human RecQ helicases reveals their role in regulating homologous recombination, a DNA repair pathway. Mutations in these enzymes cause cancer-predisposition syndromes, highlighting their importance in maintaining genomic stability.
Researchers have shed new light on how the Hepatitis C helicase plays its role in duplicating genes by tracking the gradual separation of nucleotide pairs. The study found that the helicase unwinds DNA in discrete jumps, requiring three ATP molecules for each reaction.
Cornell researchers have solved a fundamental question about DNA strand separation by demonstrating the active role of an enzyme called helicase. The study found that helicase exerts a force onto the fork and separates the two strands, contradicting earlier passive unwinding mechanisms.
Researchers describe two structural forms of human RECQ1 helicase, which regulate its dual enzymatic activity. The larger complex is associated with DNA strand annealing, while the smaller form carries out DNA unwinding.
Researchers found that motor proteins can snap back to their starting point when hitting obstacles, potentially playing a role in maintaining genome integrity. This 'recycling action' may prevent the accumulation of toxic proteins on DNA.
Researchers at Yale University have made significant breakthroughs in understanding the helicase function of the hepatitis C virus. By visualizing the behavior of the viral enzyme NS3, scientists discovered that it moves with a discontinuous stepping motion that alternates rapid translocation with pausing.
Researchers from Case Western Reserve University School of Medicine have discovered that RNA helicases can displace proteins from single-stranded RNA and change shape without unwinding duplexes. This finding redefines the mechanism of action of RNA helicases, providing new insights into their roles in various biological processes.
Scientists have developed a 3D image of the UvsW enzyme, crucial for understanding replication-dependent replication in human cells. The findings reveal how this enzyme orchestrates the process by which viruses, plants and animals introduce new genes into DNA during replication.
New research has solved a long-standing mystery about DNA unzipping, revealing that it requires at least two proteins working together. The study found that if one protein falls away, the process stops and DNA reverts to its zipped state unless another protein joins in.
Harvard researchers have created the first atomic-resolution image of a donut-shaped enzyme that unwinds the DNA double helix for replication. The structure reveals how six individual polypeptide lobes arrange themselves to look like a ring of bread buns, providing new insights into the molecular motor's mechanism.
Researchers at UNC-CH discovered DNA helicase II can act individually in DNA repair, similar to fixing a car. This finding brings scientists closer to correcting defective biological processes and treating diseases like Werner's and Bloom's syndromes.
Researchers from Vertex Pharmaceuticals have solved the three-dimensional atomic structure of the hepatitis C virus NS3 helicase enzyme, an enzyme critical to viral replication. The achievement provides valuable insights into the mechanism of helicase enzymes and offers opportunities for accelerating antiviral drug development.