Articles tagged with Lectins
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers developed a new way to stimulate the immune system to attack tumor cells by blocking an immune checkpoint. They created multifunctional molecules called AbLecs, which combine a lectin with a tumor-targeting antibody, and showed they could boost the immune response to cancer cells.
Researchers identified hundreds of hidden binding partners for a blood protein receptor, revealing links to organ dysfunction and increased sepsis risk. The study found that Mrc1's absence led to the accumulation of mannosylated proteins, which disrupted normal physiology and function.
Researchers have reexamined the Ashwell-Morell receptor's functions using innovative glycoengineering techniques, clarifying its roles in sepsis and inflammation control. The study reveals that the receptor can bind to a specific type of protein glycan chain, which was previously thought to be incompatible with binding.
The study found that decreasing LSECtin levels increases specific immune cells that contribute to disease progression, suggesting restoring these levels could restore altered liver functions. Researchers restored LSECtin activity in cirrhotic animal cells using anti-inflammatory mediators, proposing a potential therapeutic strategy.
Researchers at Université de Montréal's Department of Chemistry have created a new fluorogenic probe to study interactions between sugars and proteins, which are essential to life. The probe can visualize these interactions using fluorescence, providing a valuable tool for studying biological processes critical to human health.
MIT chemists develop rapid test to determine whether individuals have neutralizing antibodies against Covid-19, offering protection against future infections. The technique uses a fingerprint of sugar molecules to identify neutralizing antibodies in blood samples.
Researchers have discovered a mechanism in Pseudomonas aeruginosa bacteria that likely contributes to the severity of infections and could be a target for future treatments. The study found that the lectin LecB renders immune cells ineffective, preventing them from triggering an immune response.
Research from Brigham and Women's Hospital found that genetic analysis can identify up to 65% more A2 donors, increasing potential kidney transplants for recipient candidates with blood type B. This could improve availability and equity in kidney transplantation.
A banana protein-derived therapy called H84T-BanLec has been shown to be effective against all known strains of the flu and all human-infecting coronaviruses, including SARS-CoV-2. The therapy works by binding to high-mannose glycans on the surface of viruses but rarely found on normal human cells.
Researchers found that HIV prefers to infect memory CD4 T cells with large amounts of specific sugars, including fucose and sialic acid. The study also reveals that HIV boosts the production of these sugars in infected cells, highlighting a new target for potential treatments.
Researchers identify a molecular culprit for COVID-19's seasonal nature, finding a galectin-like structure on the spike protein that responds to external seasonal patterns. This discovery could help predict future mutations and potentially pave the way for new therapeutics or vaccines.
Researchers identified two lectins, Clec4g and CD209c, that strongly bind to the SARS-CoV-2 Spike protein, blocking viral entry into cells. These findings hold promise for developing robust therapeutic interventions against circulating variants.
A new function of Pseudomonas aeruginosa lectin LecB has been discovered: it blocks the cell cycle in host cells, leading to slowed or halted wound healing. This impairment occurs through the silent internalization of growth factor receptors, triggering intense vacuolization and cell death.
Researchers discovered a mechanism by which bacteria like Burkholderia ambifaria activate white blood cells and attack the immune system. The study found that lectin BambL binds to carbohydrate residues on the surface of B cells, triggering an immune response in immunocompromised hosts.
Researchers found that combining low doses of paraquat herbicide with sugar-binding proteins called lectins triggered Parkinsonism-like symptoms in rats. The study suggests that the toxin travels from the stomach to the brain, forming a misfolded protein alpha-synuclein that causes the disease.
Researchers have developed a microgel scavenger that targets intestinal toxins, reducing inflammation and supporting natural gut flora. The new therapy has the potential to treat conditions caused by bacterial infections, such as C. difficile-induced colitis.
A recent study reveals galectin-3's ability to interact with GAGs and proteoglycans, challenging previous biological functions. This discovery has significant implications for cancer treatment and research into immunodeficiency, neural growth, and inflammation.
Researchers have discovered a new class of compounds that stick to the sugary coating of the AIDS virus and inhibit its entry into cells. The synthetic lectins, developed from a compound called benzoboroxole, show promise as a potential microbicide to prevent HIV infection.
A Scripps Research team has overcome a major purification problem for stem cells, enabling more reliable and safe treatments. The new method uses lectin arrays to separate stem cells from other cell types, promising significant cost savings and reliability improvements.
A new injection has been developed to limit the devastating consequences of heart attacks and strokes, with potential applications in transplant surgery. The injection targets a key enzyme responsible for inflammation, neutralizing its effects and significantly reducing tissue damage.
Researchers have identified BanLec, a lectin in bananas, as an effective anti-HIV agent that can inhibit HIV infection by binding to the sugar-rich HIV-1 envelope protein. This discovery could lead to the development of new microcides to prevent sexual transmission of HIV.
EhROM1 enzyme plays a crucial role in E. histolytica's immune evasion and surface protein shedding. The discovery paves the way for developing rhomboid inhibitors as a novel anti-parasitic strategy.
Researchers genetically engineered a mosquito to release sea-cucumber protein, which impairs malaria parasite development in the insect's gut. The study shows promise for preventing transmission of malaria by disrupting parasite growth and development.
Researchers genetically engineered mosquitoes to release a sea-cucumber protein that impairs malaria parasite development, potentially preventing transmission. The study shows promising results but still requires further work before being effective in real-world scenarios.
Lectins, a family of proteins found in undercooked legumes and grains, can make people feel temporarily miserable by disabling GI tract cells from repairing tears. This can lead to gaps in the epithelial lining, exposing the nasty internal world of the GI tract to the blood supply.