Articles tagged with Lysozymes
A study reveals that oral lysozyme can restore a healthy gut balance and reverse signs of vascular aging in older adults. The research identifies the PI3K–Akt signaling pathway as a key mediator, suggesting new lines of research into metabolites and microbial strains for vascular health.
Researchers identified a gut-lung axis driven by intestinal antimicrobial peptide expression and mediated by the intestinal microbiota that influences hyperoxia-induced lung injury. Supplemental lysozyme reduced lung injury in neonatal mice, suggesting a potential therapeutic target.
Researchers developed a novel hybrid protein complex by binding lysozyme to copper for enhanced reactive oxygen species (ROS) removal. The CuST@lysozyme hybrid protein showed high SOD activity and stability in biological fluids, paving the way for its therapeutic applications.
Researchers have developed a novel technology for nanoencapsulation of bioactive compounds, specifically anthocyanin, using pectin and lysozyme. The methodology ensures slow release of the compound, allowing it to survive gut bacteria and digestive enzymes.
Scientists developed an AI system, ProGen, that can generate artificial enzymes from scratch, working as well as those found in nature. The AI model learned aspects of evolution and was able to tune its generation for specific effects, creating proteins with unique properties.
A new study found that a subtilisin-like proteinase from Bacillus pumilus 3-19 exhibits proteolytic activity in Pichia pastoris, dependent on incubation time and signal peptide choice. The production of this enzyme makes the system promising for developing new feed additives for animal husbandry.
Researchers have identified a unique enzyme used by predatory bacteria to rupture the cell wall of its prey bacteria and exit without damaging its own cell wall. The discovery of this novel lysozyme holds promise for developing new therapies against antibiotic-resistant pathogens.
The team used terahertz-frequency light to probe the vibrational modes of lysozyme, discovering that its glassy and fractal nature explains the anomalously large vibrations. The study may lead to improvements in industrial glass manufacturing by understanding disordered materials.
A Rutgers-Newark study discovered that lysozyme in the gut stimulates inflammation in some people with ulcerative colitis, leading to ulcers and sores in the large intestine. The study may help develop future treatments for inflammatory bowel disease by gaining insights into immune balance.
Researchers developed a fluorescence-based technique to monitor single molecules, accelerating structural biology and potentially aiding in structure-guided drug design. The technique uses FRET to visualize biomolecules with unprecedented spatial and temporal resolution.
Gonorrhea researchers have identified a novel protein that powers the virulence of the bacteria causing gonorrhea, opening the possibility of a new target for antibiotics. The discovery could lead to the development of a vaccine and improved treatment options for the highly damaging disease.
Researchers at Newcastle University have identified how lysozyme and penicillin work together to cause recurrent infections, shedding light on why some patients become resistant to antibiotics. The study also reveals the formation of L-forms, bacteria that can grow in human tissue without cell walls, leading to recurring infections.
Scientists from Ural Federal University and the University of Limerick proved that lysozyme exhibits piezoelectric properties, generating electric charges that can power pacemakers and stimulate nerve endings. This discovery has implications for various biomedical applications, including biosensors for disease detection.
Researchers at the University of Limerick have discovered that applying pressure to crystals of lysozyme, a protein found in egg whites and tears, can generate electricity. This finding has significant implications for innovative applications such as electroactive coatings for medical implants.
Proteins' tiny motions, called vibrations, enable interactions with other molecules. A new study shows that the direction of these vibrations matters more than previously thought, shedding light on how proteins interact and facilitating tasks like absorbing oxygen and repairing cells.
Researchers found that lysozyme increases in the brains of Alzheimer's patients and has favorable effects on fly models of the disease. The findings indicate that lysozyme may represent a clinical marker for Alzheimer's and a potential therapeutic strategy to slow disease progression.
Researchers at SLAC's Linac Coherent Light Source (LCLS) X-ray laser used the technique to generate an accurate model of lysozyme, a well-studied enzyme found in egg whites. The study opens the door to new discoveries and explores the potential for LCLS to play a leading role in studying important biomolecules of unknown structure.
A study found that colistin resistance in bacteria also makes them resistant to the human immune system's defense mechanisms, such as LL-37 and lysozyme. This cross-resistance increases the risk of complications for patients with life-threatening multi-drug resistant infections.
Researchers at UC Davis found that goats' milk carrying higher levels of the antimicrobial protein lysozyme successfully treated diarrhea caused by bacterial infection in young pigs. The study suggests that such milk may eventually help prevent human diarrheal diseases, which claim millions of lives annually.
An international team led by SLAC National Accelerator Laboratory has used the world's most powerful X-ray laser to obtain ultrahigh-resolution views of nano-crystals of biomolecules, including a small protein found in egg whites. This technique enables researchers to view molecular dynamics at a time-scale never observed before.
Scientists used a novel X-ray technique to analyze the structure of hen egg white lysozyme at a high resolution of 0.19 nanometres, demonstrating the potential of free-electron lasers in structural biology. The technique, which uses ultrashort X-ray pulses, enables the study of previously intractable molecular structures.
Scientists have successfully imaged biomolecules at individual atom level using X-ray lasers, enabling new avenues for biological research. The technique, known as serial femtosecond crystallography, has been used to study a small protein called lysozyme and holds promise for understanding complex biological systems.
Purdue University scientist Kevin Keener's research suggests that rapidly cooling eggs can increase the activity of lysozyme, an enzyme that defends egg whites from bacteria. By re-saturating egg whites with carbon dioxide and altering pH levels, the technology aims to create a safer food product.
An antibacterial enzyme found in human tears and body fluids, lysozyme has the potential to eliminate anthrax-producing bacteria from processed foods. The study shows that lysozyme application can kill Bacillus anthracis spores, including avirulent forms.
Researchers at the University of Oregon have successfully demonstrated that specially synthesized boron compounds can be accepted by biologically active enzymes. This breakthrough could lead to new drug design strategies and boost boron's expanding use in medicine.
Cystic fibrosis patients may benefit from a new therapeutic strategy that targets deadly bacterial infections by manipulating the binding of antimicrobials in mucus. By reducing the charge on lysozyme, researchers found it could float independently in the mucus and kill bacteria effectively.
A new protein, Lyz, has been discovered to transform into a different structure, enabling medical researchers to design drugs that can turn proteins on or off at the cellular level. This discovery could lead to treatment for difficult-to-cure diseases such as cancer and HIV.