Articles tagged with Map Kinases
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Researchers at EMBL Grenoble have obtained the first structure of p38α being activated by MKK6, opening up new directions for developing drugs to stop cytokine storms. The inflammatory response is triggered by a series of kinases, and inactivating p38α could prevent inflammation from occurring.
Researchers discovered that master-regulatory proteins SPEECHLESS and SCREAM regulate stomatal differentiation in plants. The exact mechanism of how these proteins interact with MAP kinases MPK3 and MPK6 was unclear until recently.
Researchers at Ruhr-University Bochum have discovered a new scaffold protein called PRO40 that plays a crucial role in the production of fruiting bodies in hyphae fungi. By binding to specific kinases, PRO40 enables signal transmission and regulates MAP kinase modules.
Researchers at Brown University have created an unprecedentedly detailed description of a kinase complex, which could lead to new therapeutic drugs for diseases such as Alzheimer's and cancer. The team discovered a unique binding site, called KIS, that plays a crucial role in the complex's formation.
Researchers created a mouse model of EDMD to investigate gene expression changes in the heart. They found increased expression of MAP kinases, which play roles in other forms of cardiomyopathy. This discovery opens possibilities for treating lamin-related cardiomyopathies with MAP kinase inhibitors.
Researchers have discovered a new inhibitor called hSef, which regulates the Ras/ERK MAP kinase cascade by limiting ERK activity to specific regions of the cell. This discovery provides insights into how cellular signals are localized and controlled within the cell.
A study by Emory University scientists identified the MAP kinase signaling pathway as a key player in early melanoma development. The researchers found that this pathway is abnormally activated in early melanomas, but not in precancerous moles. This finding has implications for diagnosis and treatment of melanoma.
Scientists discover that enzymes like p38 contain two binding sites, one for active site and another to tether substrate. This new understanding reveals a switch-like mechanism in cellular signaling.
A University of North Carolina Health Care study led by Lee Graves clarifies how cells grow and suggests new drug targets for cancer cells. The research focuses on the MAP kinase enzyme and its role in regulating cell growth.