Articles tagged with Molecular Targets
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
The collaboration aims to accelerate the development of small molecule inhibitors for treating metabolic diseases. Insilico will utilize its Pharma.AI platform to design and optimize novel molecules, while Qilu will handle subsequent development and commercialization.
The article highlights Insilico Medicine's exclusive contributions to two chapters in the latest AI for Drug Discovery Volume, showcasing its expertise in real-life application of AI in early drug target-related tasks. The company's roadmap to 2030 using Quantum Machine Learning (QML) algorithms is also presented, with successful case ...
The companies will jointly develop ISM8969, a brain penetrant NLRP3 inhibitor for treating neuroinflammation-related diseases. Preclinical data shows the molecule's efficacy and favorable safety profile.
Insilico Medicine's Phase IIa clinical trial assesses Garutadustat's safety and efficacy in ulcerative colitis. The novel PHD inhibitor has shown favorable safety and tolerability profiles in completed Phase I studies.
Insilico Medicine collaborates with Servier to develop novel therapeutics in oncology through AI-driven platform Pharma.AI. The partnership is focused on identifying promising targets and generating molecular structures with desired properties.
Insilico Medicine raised a total of HKD 2.277 billion in its largest Hong Kong biotech IPO, with 94,690,500 shares offered globally and oversubscribed by approximately 1427 times. The company aims to advance its mission of extending human productive longevity using AI-powered drug discovery and development.
Researchers at Harvard Medical School have uncovered crucial insights into how a new class of antiviral drugs works, shedding light on an important tool for fighting drug-resistant strains of herpes simplex virus. The discovery may lead to new pathways for treating herpesviruses and other kinds of DNA viruses.
Researchers developed a new imaging technique called vCATCH to map drug binding in individual cells throughout the entire mouse body. The method revealed unexpected binding sites for two cancer drugs, providing clues about their side effects.
Scientists have discovered a shape-shifting molecular valve in PANX1, a cellular gate that controls the flow of chemical messages. Researchers found that a common antimalarial drug can enhance or inhibit this gate's activity, paving the way for precision therapies.
Insilico Medicine and Taigen Biotechnology collaborate to develop and commercialize ISM4808, an AI-driven PHD inhibitor for treating anemia of Chronic Kidney Disease (CKD). The partnership grants TaiGen exclusive rights for further development, commercialization, and sub-licensing in the Greater China area.
Insilico Medicine's Chemistry42 platform enables the efficient discovery of a potent, oral CBLB inhibitor with low toxicity risks and favorable ADME/PK profiles. The compound demonstrates strong in vitro activity and improved metabolic stability in mouse, rat, and dog models.
Insilico Medicine has nominated ISM3830, a highly selective CBLB inhibitor, as a preclinical candidate for advanced tumor immunotherapy. ISM3830 showed robust anti-tumor activity in multiple murine models and induction of long-term tumor immunity.
A new computational tool called DeepTarget predicts direct and indirect targets of cancer drugs, revealing that small molecules can have different targets and effects depending on the disease and cell type. The study demonstrates the tool's superior performance in real-world scenarios, highlighting its potential to accelerate drug deve...
The collaboration combines Insilico's Pharma.AI platforms with Lilly's expertise to discover and advance new therapies. Insilico will utilize its platform to generate candidate compounds, accelerating the development of transformative treatments for urgent patient needs.
Researchers focus on unraveling immunoregulatory mechanisms in sepsis, exploring the NF-κB and JAK/STAT signaling pathways. Emerging treatments aim to mitigate hyperinflammation and prevent organ failure through personalized, multi-target modulatory approaches.
UCSF researchers found a key cellular switch driving pulmonary fibrosis and developed a new therapy to block it in mice. The treatment works by preventing healthy lung cells from converting to harmful cell types, reducing scarring and improving lung function.
Researchers at the University of Bath develop a peptide fragment that locks alpha-synuclein into its healthy shape, blocking toxic clumps that cause nerve cell death. The breakthrough demonstrates the potential of rational peptide design to transform large proteins into compact drug-like molecules.
Pharma.AI is a comprehensive generative AI-powered drug discovery platform featuring PandaOmics, Generative Biologics, Chemistry42, Science42: DORA, and PreciousGPT. These platforms enhance target and biomarker discovery, biologics engineering, small molecule design, scientific research, and disease modelling.
Researchers created a glycan-binding protein that can analyze and treat diseases via sugar patterns found on the surface of cells. The tool, named sCore2, was developed by retraining an enzyme to bind to specific sugars, providing a new way to study glycans and their role in disease.
Insilico Medicine has completed IND-enabling studies for ISM8969, an orally available NLRP3 inhibitor targeting inflammation and neurodegenerative disorders. The drug candidate demonstrated favorable PD/PK profiles and dose-dependent efficacy in motor functions in animal models.
A Korean research team has developed a new single-atom catalyst that selectively performs only peroxidase-like reactions while maintaining high reaction efficiency. The platform enables test results to be read within minutes in near-physiological conditions, improving medical accessibility and ensuring timely treatment.
The Insilico Medicine recent summer updates webinar introduced new features and functional updates to the company's generative AI platform, including Generative Biologics, Chemistry42, PandaOmics, DORA, and PreciousGPT. These updates aim to accelerate drug discovery and advance life sciences research.
Insilico Medicine's latest Pharma.ai updates showcase advancements in Biology42 and Chemistry42, enhancing antibody design and omics data analysis. The company's AI software suite has demonstrated significant efficiency improvements in practical applications, setting a benchmark for AI-driven drug research.
At the upcoming AI for Good Global Summit, Alex Zhavoronkov PhD will discuss the future potential of generative AI. Insilico Medicine's founder and CEO has invented critical technologies in generative AI and reinforcement learning, and his keynote will explore applications in drug discovery and longevity.
A new gene therapy delivery device called NANOSPRESSO could revolutionize how hospitals treat rare diseases by allowing them to create personalized nanomedicines in-house. This democratized approach to precision medicine could boost access to low-cost bespoke gene and RNA therapies, especially in low-resource settings.
Insilico Medicine has completed the first-in-patient dosing of ISM3412, a novel MAT2A inhibitor with potential as a best-in-class treatment for locally advanced and metastatic solid tumors. The Phase 1 study aims to evaluate safety, tolerability, and preliminary anti-tumor efficacy of ISM3412.
Researchers at EPFL have created ultra-selective aptamers that target specific binding sites on viral spike proteins with unprecedented precision. These multivalent binders show stronger and more selective binding affinities than traditional monovalent binders, making them promising for biomedical diagnostics and therapeutics.
The Phase IIa trial of Rentosertib showed encouraging clinical data, with patients receiving the treatment experiencing significant improvements in lung function compared to placebo. The study also validated the biological mechanism of TNIK inhibition using exploratory biomarkers analyses.
The Psychedelics journal has expanded its focus to include all psychoactive drugs, challenging traditional classifications and embracing a broader understanding of consciousness-altering substances. This move aims to reveal novel therapeutic applications and deepen human knowledge of the mind.
Researchers developed a carbene-catalyzed phthalide ether functionalization method, creating chiral phytovirucides targeting the viral Nia protein. The compounds showed superior antiviral efficacy against Potato virus Y (PVY), with potential for developing new plant viruses management strategies.
Researchers at MD Anderson Cancer Center present promising results from clinical trials in three minisymposia abstracts. The studies explore personalized vaccine combination therapy for colorectal cancer, radiotherapy to avoid toxicities of systemic treatments for kidney cancer, and engineered exosomes to silence mutant KRAS in pancrea...
A new study finds that radioiodine therapy significantly increases relative survival rates in differentiated thyroid cancer patients, with benefits observed across low-, intermediate-, and high-risk subgroups. The treatment reduces recurrence rates and improves long-term survival in high-risk groups, while also showing promise for low-...
A research team developed a novel strategy to balance high catalytic activity and durability under industrial-level conditions. They constructed a MOF@POM superstructure that undergoes an in-situ transformation into a single-layer CoFe hydroxide catalyst, exhibiting exceptional performance in alkaline electrolytes.
Long non-coding RNAs (lncRNAs) play a crucial role in regulating the tumor microenvironment, influencing processes such as immune evasion, angiogenesis, and metastasis. They mediate interactions between tumor cells and their surrounding microenvironment, modulating stromal cell activities and promoting tumor growth and survival.
A recent study discovered that simultaneously targeting PIKfyve and KRAS-MAPK can eliminate tumors in preclinical human and mouse models. This approach shows promise for treating pancreatic ductal adenocarcinoma, the most common type of pancreatic cancer, which is challenging to treat due to its cellular environment.
A new study at Stellenbosch University found that blocking the enzymes involved in glycolysis could cut off the malaria parasite's primary energy source and kill it. This approach has shown promise for developing new malaria drugs, particularly against resistant parasites.
Researchers at UCSF's AViDD Center have developed powerful drug candidates that outperformed Paxlovid in preclinical testing against SARS-CoV-2 and MERS. The compounds could inhibit coronaviruses in general, providing a head start against future pandemics.
Researchers have discovered a new druggable cancer target, NPM1, which is expressed on the surface of malignant AML cells. Monoclonal antibodies targeting NPM1 showed robust anti-tumor activity in multiple in vivo models of AML, with no apparent toxicity to non-cancerous blood cells and stem cells.
A research team at the California NanoSystems Institute has created the most detailed 3D map yet of the flagellum on Trypanosoma brucei, which causes sleeping sickness. The study identified 154 different proteins that make up the flagellum, including 40 unique to the parasite.
Researchers at UT Arlington's CIHI are developing innovative solutions to address complex health needs in children with disabilities, behavioral health issues, and medical conditions. The projects aim to improve healthcare services, enhance quality of life, and promote healthier aging through cutting-edge research and model organisms.
Researchers at Texas Tech University Health Sciences Center have received a $1.94 million grant to study inhibitors that target peripheral neuropathic pain. The project aims to develop novel non-opioid and non-addicting therapies capable of effectively managing chronic pain.
Bacteria use tactile sensors to detect surfaces and trigger biochemical signals for colonization. Understanding mechanosensing is crucial for improving gut health and preventing biofouling in industries.
Participants who took the supplement showed improvements in grip strength, lower body mobility, and reductions in body weight. The supplement appeared to reduce stem cell turnover, regulate immune function, and influence gene activity related to stress response.
Insilico Medicine's Pharma.AI Day 2025 will showcase the latest AI breakthroughs and updates, including precision target discovery engine PandaOmics and generative biologics platform Generative Biologics. The company aims to accelerate drug discovery and advance life sciences research with its proprietary platform.
Researchers have found that targeting PGM3 can help stop the growth of glioblastoma, a fast-growing brain tumor. By blocking this enzyme, tumors can be effectively suppressed.
Researchers from the UCLA Health Jonsson Comprehensive Cancer Center are presenting new findings on combination therapies for liver and pancreatic cancers, including a new organoid model for personalized head and neck cancer treatment. Additionally, they are discussing the potential of liquid biopsies for cancer detection and monitoring.
Researchers have discovered RNA pseudouridine as a novel diagnostic target for colorectal cancer. The study found correlations between pseudouridine modifications and clinical markers, enabling potential non-invasive diagnosis. The findings provide a molecular framework for RNA epigenetics-based stratification and targeted interventions.
A novel radiolabeled antibody targeting the cancer antigen IL13Rα2 has been developed with high specificity for diagnosing and treating solid tumors. The antibody was effective in delineating malignancies at a low injected mass dose, making it a potential candidate for radioimmunotherapy applications.
Researchers have uncovered the molecular mechanism of ATG-9 in regulating lysosome integrity by modulating phospholipid distribution. This study suggests that reduced ATG-9 scramblase activity facilitates lysosome biogenesis and repair, highlighting ATG-9 as a promising therapeutic target for diseases related to lysosomal dysfunction.
Researchers develop novel synthesis method for multi-shelled gold clusters and precisely remove atoms to study magnetic spin influence on catalytic behavior. They find that spin density concentrates more on iodine atoms than sulfur atoms, indicating potential role in tuning catalytic properties.
Researchers discovered that aging causes inflammation, oxidative stress, and gene disruption in the retinal pigment epithelium, a vital layer of cells in the eye. This study provides a clearer understanding of why aging leads to eye disease and introduces a reliable laboratory model for testing new therapies.
A novel brain study uncovers the critical role of the HDAC5 enzyme in regulating gene expression and neuronal activity, which can trigger relapse in individuals with substance use disorders. The study highlights a new molecular target for developing novel treatments to reduce relapse risk.
Researchers have found that a specific protein modification to the immune protein MDA5 can block viral replication and reduce heart inflammation. The study's findings could lead to the development of broad-spectrum antiviral treatments that target multiple viruses.
Researchers have developed a new approach to overcome treatment resistance in estrogen receptor-positive (ER+) breast cancer. Dual aromatase-steroid sulfatase inhibitors (DASIs) show promise in effectively blocking both enzymes involved in oestrogen production, potentially reducing tumour growth.
Isowalsuranolide activates autophagy-dependent cell death by targeting TrxR1/2, leading to ROS-mediated lysosomal biogenesis and reduced cell growth. The study reveals the TrxR1/2-p53-TFEB/TFE3 axis as a key regulator of cellular homeostasis in cancer.
A promising new target for a Lyme disease vaccine has emerged: the Lyme bacterial protein CspZ. Genetic engineering revealed hidden regions that trigger a strong immune response. The modified protein promotes continuous production of protective antibodies, reducing the need for booster shots.
Researchers have isolated three new bitter compounds from the mushroom Amaropostia stiptica and found that one of them, oligoporin D, stimulates a specific human bitter taste receptor type at very low concentrations. This discovery expands knowledge of natural bitter compounds and their receptors, which could lead to new applications i...
Researchers investigated why bones become less responsive to exercise with age, finding increased mtROS or decreased Atg7-dependent autophagy in osteoblastic cells do not contribute to reduced mechanoresponsiveness. Damage to the bone's osteocyte network also does not prevent a healthy bone-building response.
Researchers found that combining imipridones with radiation therapy and temozolomide slowed glioblastoma growth and prolonged survival in mice. The treatment also boosted immune responses and suppressed MGMT protein expression, making it more effective.
Researchers at MIT have developed a method to mass manufacture nanoparticles that target cancer cells, eliminating the need for manual polymer mixing and streamlining production. This approach integrates good manufacturing practice (GMP)-compliant processes, making it suitable for large-scale production of cancer treatments.