Articles tagged with Notch Proteins
Researchers at Karolinska Institutet used DNA origami to activate the Notch receptor in a new way, revealing it can be activated 'on demand' with the help of a protein called Jag1. The study opens new avenues for understanding the Notch signalling pathway and its role in serious diseases like cancer and Alagille Syndrome.
Researchers discovered that distinct Notch family members are modified differently by phosphorylation, leading to opposite effects on transcriptional activity and oncogenic behavior. The study suggests that targeting PIM or Notch proteins may provide new treatment options for hormone-dependent breast cancer with poor prognosis.
Researchers have identified a key piece of the Notch signaling pathway, specifically a domain within the Notch receptor that is crucial for determining which ligand to bind. This finding provides a molecular handle for future studies and potential therapeutic targets for diseases such as cancer.
Researchers found that Notch protein represses the pathway in cells emitting signals, but activates it in neighboring cells. This discovery may lead to more effective therapies against cancers such as leukemia and breast cancer.
Notch signaling pathway activation has been linked to tuberous sclerosis complex (TSC) tumors. Inhibition of Notch was shown to suppress tumor growth in rat cells deficient in either TSC1 or TSC2. These findings support a role for TSC proteins in regulating Notch activity.
Researchers discovered the rumi gene's effect on bristles in fruit flies, finding a subtle loss of Notch activity at 25 degrees C. The protein associated with rumi is an O-glycosyltransferase that adds glucose to the Notch protein.
Researchers at RIKEN Center for Developmental Biology identified Nedd4 as a key player in protecting the Notch receptor from activation. The study found that Nedd4 works as an antagonist of Notch signaling, suppressing its activity and preventing molecular loose cannons from fouling the precisely ordered workplan.