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Battling persistence in TB bacteria

Researchers found a single gene involved in iron-sulphur clusters crucial for TB bacterium's persistence. The IscS gene helps regulate the SUF operon, preventing hypervirulence and allowing the bacteria to survive harsh lung conditions.

SourceIndian Institute of Science (IISc)·JournalScience Advances·DateDec 26, 2023

Life cycle of operons yields new look at bacterial genetics

Researchers have determined the life cycle of operons, small groups of genes with related functions co-transcribed in a single strand of messenger RNA. The findings reveal that operon creation and destruction lead to large changes in gene expression patterns, suggesting adaptation to environmental stresses.

SourceDOE/Lawrence Berkeley National Laboratory·JournalPLOS Genetics·DateJul 5, 2006
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See Spot work

Researchers at Cold Spring Harbor Laboratory have discovered that Spot 42, a small RNA, differentially regulates gene expression in the E. coli galactose operon through an antisense mechanism. The study provides mechanistic insight into the process and answers long-standing biological questions.

SourceCold Spring Harbor Laboratory·JournalGenes & Development·DateJun 30, 2002