Articles tagged with Oxidases
Researchers used cryo-EM to investigate the molecular basis of functional diversity in alcohol oxidase isozymes. The study found structural differences in cofactor binding and amino acid residues that affect enzyme stability and catalytic performance, ultimately resulting in distinct roles among the variants.
Researchers at Nagoya University have developed a new method called SMART that accelerates enzyme evolution and reduces costs by accelerating the selection period from weeks to days. The system uses mRNA display, next-generation sequencing, and bioinformatics to identify superior enzyme variants.
Researchers developed a battery-independent fluorescent nanosensor for continuous, reversible, and non-invasive bioimaging of glucose levels in body fluids and tissues. The sensor uses an inactive form of the glucose oxidase enzyme, eliminating toxic byproducts and enabling reliable detection.
Research suggests visfatin stimulates membrane raft clustering, leading to NLRP3 inflammasome activation and podocyte injury. The study highlights the role of membrane raft redox signaling in visfatin-induced inflammation and kidney damage.
A team at Osaka University used neutron crystallography to image the atom-by-atom structure of a copper amine oxidase enzyme, revealing unprecedented structural insights. The study provided details on the protonation/deprotonation state and motions of key cofactors, facilitating single-electron transfer.
A new enzyme, CtdY, has been identified that can break an amide bond, a fundamental type of bond found in proteins. This discovery holds significant promise for the pharmaceutical industry, as it could enable the creation of new anticancer drugs and improve treatment outcomes.
A study suggests that the powerhouse-pruning protein Drp1 plays a crucial role in generating energy for new blood vessel growth, particularly under low oxygen conditions. When oxygen levels are low, Drp1 gets modified to produce reactive oxygen species (ROS), which enables glycolysis and subsequent cell signaling.
Researchers found elevated plasma xanthine oxidase activity and more fragments of damaged mitochondrial DNA in Black adults with resistant hypertension compared to white adults. These findings suggest an important underlying cause of increased cardiovascular risk in Blacks with difficult-to-treat hypertension.
Researchers developed a simple synthesis method for Co nanoparticles using melted imidazole as solvent, improving activity and stability. The synthesized material simulates the function of natural NADH oxidase, consuming NADH in cancer cells to induce oxidative damage.
Researchers successfully mimic nano spatial compartments to create artificial mitochondria, capable of supplying ATP or other useful molecules to cells in damaged or diseased tissues. The artificial organelles are generated from Exosome fusion and can function as energy reserves in the damaged tissues.
Acidobacteria use low-affinity terminal oxidases to 'breathe' oxygen at nanomolar concentrations, challenging traditional assumptions. These microbes also scavenge atmospheric hydrogen to survive nutrient-poor periods, playing a central role in soil microbial communities and ecological balance.
Researchers identified a core set of 24 genes that activate in response to bacterial colonization, acting as volume control for plant responses and predicting the extent of colonization
The study reveals that bacteria have multiple oxidases, with cytochrome bd oxidase playing a crucial role in energy production and stress protection. The novel findings provide insights into the development of new antimicrobials targeting pathogens.
Scientists from the University of Tsukuba have isolated bacteria that break down cyclic imines, a key component in medicines for hypertension. The discovery highlights copper amine oxidase as the enzyme responsible for this process.
Researchers capture snapshots of crystal structures in biochemical pathway that enables us to breathe, providing key insights into aerobic respiration. The study uses a new 'diffraction before destruction' method to determine the structure of an oxygen intermediate in cytochrome c oxidase.
A study found that the monoamine oxidase A gene is linked to self-assessed well-being and stress levels among men. The researchers suggest that genetics can influence social phenomena, and this connection may be significant for understanding human behavior.
The study investigates the susceptibility of TSNPRs to H2O2 etching, revealing that small-sized TSNPRs capping with citrate show great interest for glucose sensing. The research offers an ultrahigh sensitive analytical platform for point-of-care diagnostics.
Bacteria access oxygen for energy production in crowded, oxygen-deprived environments through a specific terminal oxidase and phenazine molecules. This discovery could inform the development of new therapies for cystic fibrosis infections.
Scientists identify a protein that suppresses the body's key antiviral reaction, leading to stronger or more virulent disease. A new prototype drug has been found effective in suppressing disease caused by influenza infection.
A phase III clinical trial showed that combining lesinurad with febuxostat was more effective at lowering blood urate levels than febuxostat alone. The combination group achieved target urate levels in significantly more patients over 12 months.
A genetic mutation in the lysyl oxidase gene has been identified as a cause of thoracic aortic aneurysms and dissections. Researchers have found that this mutation disrupts the structure and strength of the aorta, leading to increased risk of rupture.
Russian scientists have identified a unique enzyme in E. coli that enables the bacterium to breathe, despite the presence of hydrogen sulfide, which would normally inhibit mitochondrial respiration. This discovery could lead to the development of new antibiotics that target specific types of bacteria without harming human cells.
Researchers from the University of Vienna have successfully characterised aurone synthase, a catechol oxidase with hydroxylase activity. The study provides insights into the mechanism of plant polyphenol oxidases and has potential applications in biotechnology, pharmaceuticals, and agriculture.
A study found that compounds in New Zealand blackcurrants increased mental performance indicators such as accuracy and attention, while also reducing the activity of monoamine oxidase enzymes. This may lead to potential benefits for brain health and managing symptoms of disorders like Parkinson's disease and depression.
Women with postpartum depression exhibit elevated levels of the enzyme monoamine oxidase A in their brains. The study suggests that reducing MAO-A levels could help prevent the condition, with lifestyle strategies like quitting smoking being key to lowering levels.
Researchers discovered that molybdenum trioxide nanoparticles can mimic the function of sulfite oxidase, an enzyme responsible for cellular detoxification processes. The nanoparticles can cross cell membranes and accumulate at mitochondria, recovering sulfite oxidase activity and potentially treating sulfite oxidase deficiency.
Researchers have developed a non-invasive biosensor that can detect minute concentrations of glucose in saliva, tears, and urine, with the potential to reduce the frequency of pinprick testing for diabetes. The sensor uses graphene nanosheets and platinum nanoparticles, enabling it to distinguish between glucose and other compounds.
Researchers have uncovered a key enzyme in plant immunity, NADPH oxidase, which regulates the production of toxic molecules that encourage cell death. This discovery could lead to disease-resistant crop varieties and new treatments for human immune disorders such as chronic granulomatous disease.
Researchers at the University of Southern California found that mice lacking a key enzyme are unable to properly assess threats, leading to defensive behaviors in response to neutral stimuli and reduced caution in the presence of danger. The study suggests that this deficiency may be related to an inability to adapt to environmental cues.
Researchers at NIH found that even tiny amounts of superoxide production in people with chronic granulomatous disease (CGD) are linked to better survival rates. The study allows for early assessment of patient risk, enabling personalized treatment options.
Researchers found that obstructive sleep apnea thickens blood vessels due to NADPH oxidase enzyme activation, increasing the risk of pulmonary hypertension and other heart diseases. In mice, inhibiting NADPH oxidase reduced hypoxia-induced pulmonary hypertension, suggesting potential treatment strategies.
Research at UCSD reveals ketamine impairs brain circuitry by increasing superoxide production, leading to memory and attention problems. Inhibiting NADPH oxidase could provide novel treatments for schizophrenia.
Researchers replaced a single amino acid in a modern desaturase enzyme to create an oxidase, revealing similarities with a simple peroxidase. This substitution supports the theory of a common origin for the two enzymes around 2.5 billion years ago.
Researchers discovered that reactive oxygen species are essential for the development of balance machinery in the inner ear. The study found that a specific mutation in the Noxo1 gene, which encodes an NADPH oxidase enzyme, led to impaired balance and altered posture in mice.
Scientists at Johns Hopkins Medicine have found that a low-dose combination of arsenic and bryostatin can kill APL cell lines by activating the cancer cells' natural self-destruct mechanism. This therapy has potential for treating treatment-resistant acute promyelocytic leukemia, a subtype of acute myeloid leukemia with poor outcomes.
Researchers identified a critical protein, NADPH oxidase 3 (Nox3), essential for otoconia development and balance. The discovery may aid in regenerating otoconia and treating balance-related disorders.
Researchers found glucose oxidase in caterpillar saliva, which converts glucose to gluconic acid and hydrogen peroxide. The enzyme suppresses plant nicotine production by 26%, making caterpillars healthier.