Articles tagged with Phosphoinositides
A team from the University of Osaka has created a high-throughput platform to engineer versatile biosensors that can track lipid molecules in living cells. This method, called Cell surface Liposome Binding (CLiB) assay, uses yeast cells and fluorescence readouts to test protein variants' binding to lipids.
Researchers discover that kinases play a crucial role in moving cholesterol to activate a growth pathway in aggressive cancers. Without these enzymes, cancer cells are blocked from fueling tumor growth. The study highlights the importance of targeting lipid enzymes as a potential treatment strategy for cancers with TP53 mutations.
A team of researchers at the University of Pennsylvania has designed a new light-controlled cholesterol molecule that selectively targets two poorly understood sterol transport proteins, ORP1 and ORP2. This breakthrough enables precise spatiotemporal control over cholesterol's biological activity, paving the way for advanced therapeutics.
A new study identifies phosphatidylinositol 4,5-bisphosphate as a key regulator of the SK2 channel, which plays a critical role in cardiac ion channels and heart rhythm. The research provides critical translational insights into possible mechanisms of cardiac arrhythmias in heart failure.
A new study reveals that Salmonella uses a two-pronged approach to protect itself within the host's defense mechanisms, involving protein SopB. By altering phosphoinositide dynamics and preventing lysosome production, SopB allows the bacteria to survive inside macrophages.
A new system called PRMC-MS enables the comprehensive analysis of phosphoinositide acyl variants in various types of biological samples. This method allows for the simultaneous measurement of all eight classes of phosphoinositides and detection of tiny changes in intracellular levels.
A UCL study has found that a natural compound in beans can inhibit the growth of tumors and enhance the effect of existing anti-cancer drugs. The compound, inositol pentakisphosphate, is non-toxic and water-soluble, making it a promising therapeutic agent for cancer treatment.