Phosphoproteins

Newly discovered ‘molecular fingerprints’ could transform diabetes treatment and diagnosis

Researchers have uncovered unique molecular fingerprints for insulin sensitivity, challenging traditional binary classification of people with type 2 diabetes. These signatures can help identify individuals at risk earlier than current methods, paving the way for personalized treatments and precision medicine.

SourceUniversity of Copenhagen - The Faculty of Health and Medical Sciences·JournalCell·DateMay 27, 2025

Tiny proteins found across the animal kingdom play a key role in cancer spread

Researchers at McGill University discovered that phosphatases of regenerating liver (PRLs) are overexpressed in some cancers, making cells more metastatic and driving disease progression. The study sheds light on PRLs' role in binding magnesium transporters, a common pathway among all studied species.

SourceMcGill University·JournalJournal of Biological Chemistry·DateMay 15, 2023

Message received: Scientists identify the molecular mechanisms behind learning and memory, may open door to new therapeutic strategies for Alzheimer’s disease

Researchers elucidated the molecular mechanisms of acetylcholine in learning and memory, revealing a signaling cascade involving protein kinase C. The study opens doors to new therapeutic strategies for Alzheimer's disease.

SourceFujita Health University·JournalMolecular Psychiatry·TypeExperimental study·DateJun 27, 2022

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KANPHOS: Newly developed database for kinase-associated protein phosphorylation eases neural signaling research

The newly developed KANPHOS database provides comprehensive information on kinase-associated protein phosphorylation, facilitating research into neural signaling pathways. The database contains information on phosphoproteins, phosphorylation sites, and participant kinases, allowing for searches based on various parameters.

SourceFujita Health University·JournalCells·TypeExperimental study·DateMar 16, 2022

A machine learning approach to identify functional human phosphosites

Researchers at EMBL-EBI have created the largest reference phosphoproteome of almost 120,000 human phosphosites using a machine learning approach. This freely-accessible resource enables scientists to identify critical phosphosites relevant for various biological processes and diseases.

SourceEuropean Molecular Biology Laboratory - European Bioinformatics Institute·JournalNature Biotechnology·DateDec 11, 2019

Synaptic function closely tied to overall need for sleep, regardless of day or night

Two studies in mice reveal that sleep deprivation alters daily changes in synaptic functions and proteins, leading to impaired cognitive abilities. The research suggests that sleep pressure plays a crucial role in maintaining synaptic function, independent of the circadian clock.

SourceAmerican Association for the Advancement of Science (AAAS)·JournalScience·DateOct 10, 2019

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Apple AirPods Pro (2nd Generation, USB-C) provide clear calls and strong noise reduction for interviews, conferences, and noisy field environments.

What makes stem cells tick?

A team of researchers has identified phosphorylated signaling proteins in human embryonic stem cells, shedding light on the mechanisms that determine cell fate. The study's findings may lead to the development of new therapies by controlling stem cell differentiation.

SourceSanford Burnham Prebys·JournalCell Stem Cell·DateAug 6, 2009