Articles tagged with Polymerases
A study from UMBC reveals a conserved RNA-protein interaction as a promising target for broad-spectrum enterovirus antivirals. The researchers found that a fusion protein called 3CD recruits proteins to assemble the replication complex, and targeting this interface could lead to universal drugs.
A new study by researchers from Rice University has uncovered a mechanism by which the identity of nucleotides following a given nucleotide in DNA affects transcription accuracy. The discovery offers insight into hidden factors that influence transcription accuracy and may improve synthetic and therapeutic RNA.
Researchers at IOCB Prague have discovered the HelD protein's role in protecting bacterial RNA polymerase from antibiotic effects. The protein not only frees the enzyme but also ensures its recycling, allowing bacteria to multiply again.
Silent gene mutations may have significant consequences beyond their own gene, according to a study published in the Proceedings of the National Academy of Sciences. Researchers found that synonymous mutations in one gene can increase the production of a neighboring gene by recruiting RNA polymerase to cryptic transcription sites.
Researchers have developed a novel solubilizer for olaparib, a selective PARP inhibitor, using π-π-stacked poly (ɛ-caprolactone)-based micelles. The studies found that these micelles improved the solubility of olaparib and exhibited sustained release behavior in vitro.
Researchers discuss therapeutic opportunities for hypermutated urothelial carcinomas that are resistant to immunotherapy, including the potential of targeted therapies. High TMB is associated with defects in mismatch repair proteins and can lead to increased sensitivity to cancer treatments.
Researchers unveiled a previously unknown effect of PG545 in ovarian cancer cells, inducing DNA damage and promoting autophagic degradation of RAD51. This breakthrough could aid in selecting the most appropriate treatments for ovarian cancer patients with PARPi resistance.
Researchers at La Jolla Institute for Immunology have discovered the inner workings of Ebola virus replication inside host cells, revealing 'viral factories' that form clusters of viral proteins and genomes. These microscopic structures are formed in host cells and play a crucial role in the virus's life cycle.
Scientists at Münster University identified specific modifications to the influenza A virus polymerase that are triggered by host cell proteins, such as ubiquitin. These stable modifications may lead to the development of medicines resistant to viral mutations.
Researchers at La Jolla Institute for Immunology have identified a critical protein, GSPT1, that facilitates Lassa virus infection. Targeting this protein with an existing drug candidate, CC-90009, shows promise in reducing Lassa virus growth without cell toxicity.
RPA is a rapidly emerging technology for the rapid, sensitive, and economical detection of zoonotic pathogens. Its minimal sample preparation requirements and constant low-temperature performance make it suitable for field settings.
A new study sheds light on the molecular interactions between remdesivir and various viruses, revealing why it works against SARS-CoV-2 but not others like influenza. The findings aim to develop broad-spectrum therapies for future pandemics.
Researchers at UCLA have identified rare T cells capable of targeting a protein found in SARS-CoV-2 and other coronaviruses. By adding a fragment of this protein to vaccines, they hope to create a longer-lasting immune response and increase protection against new variants. This breakthrough could lead to more effective COVID-19 vaccines.
Scientists at Georgia State University have identified a potent and well-tolerated antiviral compound, GHP-88309, that targets paramyxovirus polymerases. The compound is effective against both human parainfluenzaviruses and the measles virus.
Scientists uncover the flu's secret formula for evolving within host species: balance. The virus replicates with enough mutations to spread but not so many that it leads to its demise.
Researchers found that viral polymerase is a key target for preventing systemic flu in humans. The study discovered that avian influenza adapted to infect mice caused severe illness and death due to suppression of the immune system.
Scientists have produced the first 3-dimensional image of a key influenza protein, revealing insights into transmission between birds and humans. The study sheds light on how polymerase mutations contribute to avian flu's ability to jump species barriers.