RNF167 mediates atypical ubiquitylation of RIG-I/MDA5, leading to autophagic degradation via K6-linked polyubiquitination. K11-linked polyubiquitination also promotes proteasome-dependent degradation of RLRs. This study reveals the importance of dual proteolysis in regulating antiviral immunity.
Cells use autophagy as a recycling system to transport and break down damaged organelles, including mitochondria. A recent study reveals the molecular details of how an enzyme called TBK1 participates in mitophagy, a disease-relevant process linked to Parkinson's disease.
A team of researchers at Osaka University has identified a specific enzyme complex that initiates the removal of damaged lysosomes from cells. The complex, composed of CUL4A, DDB1, and WDFY1 proteins, acts preferentially during lysophagy to facilitate the degradation process.
Researchers at VCU Massey Cancer Center have discovered a new signaling pathway linked to IL-1 and IRF1 in sterile inflammation. This discovery offers insight into the role of IRF1 in producing chemokines and recruiting immune cells, potentially leading to new treatments for autoinflammatory diseases.