Researchers developed a new, three times more effective version of the antibothropic serum used to treat snake venom poisoning. The improved serum had increased neutralizing antibodies and fewer proteins associated with side effects, resulting in greater potency and reduced risk of adverse reactions.
Researchers at TUM have developed a novel method to purify proteins using short-wave UV light, eliminating the need for chemical reagents. The 'Azo-tag' system changes shape under light exposure, allowing for targeted purification of proteins in a more efficient and gentler manner.
A team of University of Florida chemical engineers has developed a microfluidic device for DNA purification that extracts genomic DNA without centrifuges or magnetic beads. The device uses fluid flow and electric fields to remove contaminants, resulting in more accurate results and reducing DNA fragmentation.
Researchers at Osaka Metropolitan University have discovered yeast cell wall-derived proteins that exhibit high emulsifying activity, comparable to commercial casein emulsifier. These easily released protein molecules could potentially replace emulsifiers derived from milk, eggs, and soybeans, reducing allergenic concerns.
The study uses cryo-electron microscopy to observe the ETB receptor-G protein complex, revealing a strong binding interaction between G protein and ETB receptor. This finding may deepen understanding of endothelin signaling mechanisms and inform the development of new drugs.
Guan's lab will apply accumulated experience and methods to study SLC6A14, a sodium-coupled epithelial amino acid co-transporter involved in cancer and several chronic diseases. CryoEM will be used to determine the structure of SLC6A14, providing insight into its substrate specificity and inhibitory mechanisms.
Researchers at ISTA have discovered the composition of poxviral cores, a key factor in their infectivity. The study's findings could lead to the development of new therapeutics targeting the viral core.
Scientists have developed a new system to display epitopes in mammal cells for immunization studies, potentially speeding up the immunization process. This method allows for targeted immune responses against specific viral proteins without the need to purify antigens.
A team of scientists has identified a key player in the coupling between early transcription termination and RNA degradation. The ARS2 protein recruits ZC3H4, which interacts with the NEXT complex to target nascent transcripts for degradation.
MIT engineers develop a new purification method using bioconjugate-functionalized nanoparticles to rapidly crystallize proteins, reducing the cost of manufacturing protein drugs. The approach has shown promising results in isolating lysozyme and insulin, with faster crystallization times and increased nucleation rates.
Scientists have developed a novel CRISPR-Cas3 editor from the bacteria Neisseria lactamica that improves editing efficiency and is more easily produced. The tool enables 50% editing efficiency in stem cells and 95% efficiency in other human cell lines, paving the way for research in genetic diseases and developmental biology.
The study's findings provide a foundation for developing efficient protein isolation techniques from insect powders, which could help address global hunger and malnutrition issues. Insect-based protein sources are rich in essential amino acids and offer a sustainable alternative to traditional farming methods.
Researchers aim to make drug purification more efficient and scalable by understanding unwanted element interactions. They explored ligand-surface interactions using NMR spectroscopy and simulations.
The study utilizes gas-phase electrophoresis (GEMMA) to separate nanovesicles from proteins in natural samples. This allows for accurate attribution of effects to transport vesicles, crucial for understanding cellular communication and metabolism. The method has significant implications for extracellular vesicle research and its releva...
A new study from the University of Illinois at Urbana-Champaign introduces an electrochemical redox desalination process that removes up to 99% of excess salt from whey while refining over 98% of its valuable protein content. The process uses less energy and operates at a lower cost compared to conventional desalination systems.
Researchers from the University of Tsukuba have developed a new tagging system for detecting and purifying proteins in plant cells, using a short sequence called RAP tag. The approach shows high affinity and specificity, making it a powerful tool for protein purification, particularly at low expression levels.
Researchers have developed a simpler detection procedure to identify and purify specific proteins from complex mixtures. The new method uses a UV-excitable fluorophore that binds to polyhistidine tags, allowing for easy detection of tagged proteins in gel electrophoresis.
Researchers at Princeton University developed OptoBinders, light-switchable molecular tools that control cellular processes. These antibody-like proteins can bind or release targets in response to blue light, offering new capabilities for protein purification, biofuel production, and targeted cancer therapies.
A new purification technique using molecular affinity interaction has been developed to purify therapeutic proteins with high efficiency and purity. The technique uses synthetic host molecules cucurbit[7]uril and adamantane to secure manufacturability, sterilization, and recyclability of purified materials.
A new class of proteins, dubbed 'Hero', has been discovered that protects vulnerable proteins from aggregation and denaturation under extreme heat and other stresses. These flexible proteins may help prevent neurodegenerative diseases such as ALS and Huntington's disease by preserving molecular order.
Biomedical engineers create biomanufacturing platform using bursting bacteria and shrinking capsules to produce targeted proteins, enabling flexible and efficient production of diverse biologics. The new technology simplifies the creation of protein complexes and offers an easy way to produce multiple proteins simultaneously.
Researchers at the University of Alabama at Birmingham have developed a novel method for one-step protein purification that improves yield, purity, and activity by 10- to 500-fold. The CL7/Im7 affinity chromatography purification scheme overcomes weaknesses of current commercially available systems.
Researchers investigate the differences between A1 and A2 milk proteins, finding that a specific peptide is present in both types. However, the content of this peptide is higher in A1 milk, suggesting that more research is needed to determine its impact on human health.
The International Working Group on Antibody Validation has established five conceptual pillars for antibody validation, including genetic strategies, orthogonal methods, independent antibody approaches, expression of tagged proteins, and immunocapture followed by mass spectrometry. The proposal aims to provide a scientific foundation f...
A research team has mapped the structure of a unique nuclear pore complex found in trypanosomes, an ancient parasite species diverged from yeast and humans. The study reveals that the architecture of the inner ring is similar across different eukaryotes, while the outer ring exhibits distinct features, suggesting an ancient origin.
Scientists discovered that polyphosphate, an ancient chemical present in all living creatures, plays a crucial role in protein folding and can substitute for complex chaperone proteins. This breakthrough could lead to new strategies for treating protein folding diseases like Alzheimer's and Parkinson's.
Researchers are developing protein microarray technology to identify early signs of diseases such as diabetes and cancers. This technique allows for the simultaneous analysis of thousands of proteins, facilitating high specificity and reduced cost.
Michigan State University researchers Merlin Bruening and Greg Baker have invented a high-performance membrane protein purifier that can simplify the process of isolating desired proteins. This innovation has the potential to reduce costs, speed up new drug development, and improve pharmaceutical efficiency.
Scientists at Hebrew University and Harvard have developed a low-cost, 'robotic' growth factor protein that speeds up wound healing. The protein responds to temperature, simplifying purification and enabling it to remain at the burn site, dramatically increasing healing rates in diabetic mice.
Scientists at the University of Montreal and Maisonneuve-Rosemont Hospital Research Centre have cloned human sperm-binding protein BSP, which may improve fertility treatments and male contraception. The researchers successfully purified the protein after decades of trying to isolate it from human sources.
Researchers at MIT have made a breakthrough in understanding the molecular basis of smell by mass-producing olfactory receptors. This advance could lead to the development of artificial noses for various settings, including medicine and industry. The innovation involves isolating and purifying protein structures using a novel method.
Researchers have discovered a cullin-dependent E3 ligase as a crucial component of the Clr4 methyltransferase complex, controlling histone methylation and heterochromatin assembly. The study suggests that polyubiquitylation of regulatory proteins may play a key role in regulating these processes.
Researchers have developed a new purification process that combines high throughput with high selectivity, enabling more fine separations. By attaching a negatively-charged dye molecule to the protein of interest, retention is enhanced in higher proportion than when it wasn't tagged.
Researchers at New Jersey Institute of Technology have discovered a novel filtration system that can efficiently separate proteins, a crucial step for pharmaceutical applications. The new technology uses a membrane with almost identical molecular weights for proteins, making the process more cost-effective and faster.