Radical Sam

How a particular protein regulates up to two-thirds of the world’s methane emission: key mechanism for methane emission in anaerobic environments is now understood, potentially helping the fight against climate change.

Researchers have deciphered the activity of B12-dependent radical SAM enzymes, which regulate methane production by archaea. The study's findings have implications for biotechnologies that control key enzymatic events and could help reduce global warming.

The key to a powerful antibiotic’s formation now clear

Researchers have imaged an enzyme involved in carbapenem biosynthesis, shedding light on the process of creating a potent side chain that makes these antibiotics effective against antibiotic-resistant bacteria. The discovery could lead to improved antibiotics and new strategies for combating bacterial resistance.

How to modify RNA: Crucial steps for adding chemical tag to transfer RNA revealed

Researchers at Penn State have imaged a protein facilitating RNA modification, allowing them to reconstruct the process. The study reveals how a chemical tag is added to tRNA, improving its ability to translate messenger RNA into proteins.

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Synthesis of potent antibiotic follows unusual chemical pathway

Researchers at Penn State have discovered a unique enzyme-catalyzed reaction in the production of thiostrepton, a potent antibiotic that can also target breast cancer cells. The breakthrough, detailed in a new Nature Chemistry study, could lead to the development of more effective human medicines.