Articles tagged with Receptor Tyrosine Kinases
A recent study found that oleacein increases BDNF expression in human neuronal cells and reduces depressive behavior in mouse models. Gene expression analysis reveals the activation of cell cycle and neurogenesis processes, as well as a decrease in inflammatory response.
Researchers found that gatekeeper mutations in kinases can destabilize the inactive form, making them more active and prone to cancer recurrence. This could inform which drugs oncologists use as a first-line treatment.
Finnish researchers created a comprehensive map of molecular interactions between 58 human receptor tyrosine kinases (RTKs), revealing key insights into their functions and roles in disease. The study's findings can aid understanding of diseases linked to abnormal RTK activity, particularly cancer.
Dr. Adam Smith receives $650,000 CAREER award to develop a quantitative chemical model for receptor tyrosine kinases, targeting anti-cancer therapies. The project also includes education initiatives and citizen science projects.
Researchers identified a potential combination therapy to effectively use receptor tyrosine kinases inhibitors for KRAS mutant colorectal cancers by combining with MEK/ERK signaling pathway inhibitors. This approach could offer new treatment options for individuals with KRAS mutant cancers.
A joint study by Helmholtz Zentrum München and Karolinska Institutet reveals that lipid peroxides temporarily inactivate protein tyrosine phosphatases, regulating cellular communication. This finding is crucial as aberrant activation of receptor tyrosine kinases contributes to various diseases, including cancer.
Scientists discovered a receptor tyrosine kinase in single-celled choanoflagellates, a group of protists with characteristics similar to those of multicellular animals. The finding provides strong support for the hypothesis that choanoflagellates are closely related to metazoans and may represent modern examples of animal ancestors.