Articles tagged with Reporter Genes
Researchers developed a cell-based reporter assay that can quantify epigenetic changes induced by chemicals and potential carcinogens. The epi-TK assay detects gene silencing and activation, reflecting epigenetic changes associated with both gene expression and DNA methylation.
A team of researchers at Harvard's Wyss Institute and ETH Zurich have developed a computational approach to identify genomic safe harbors (GSHs) with high potential for safe insertion of therapeutic genes. The study validated two GSH sites in adoptive T cell therapies and in vivo gene therapies for skin diseases.
The CRISPR Journal publishes outstanding research on all aspects of CRISPR and gene editing. Two new articles explore the ethics of germline editing and the use of alternative PAM sequences for mouse genome editing.
Researchers at MIT have developed a new way to image a reporter gene that turns on or off to signal events in the body using MRI. This approach allows scientists to determine when and where the gene is turned on, providing insights into brain function and memory formation.
Biologists at Brown University found that gene silencing via chromatin in fruit flies declines with age, but administering life span extending measures such as lower calorie diets or increased expression of the protein Sir2 restores the loss of gene silencing due to age. The study suggests a possible line of research to develop more pr...
Researchers developed a promising new technique to track genetically engineered cells using antibody fragments as reporter genes, which could advance disease treatment. The technique offers several advantages over existing methods, including improved specificity and accuracy.
Researchers have developed a genetically modified mouse model using the ferritin reporter gene, enabling live cell imaging via magnetic resonance imaging (MRI) without additional substances. This breakthrough overcomes limitations in detecting signal changes in tissues, such as fetal development and the central nervous system.