Articles tagged with Riboswitches
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
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Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Scientists developed a new RNA-based toolkit that can regulate gene expression, potentially improving regenerative medicine, gene therapy, and biotechnology. The technology uses small molecules to control the activity of synthetic RNA, allowing for precise control over gene expression.
Researchers have developed a new approach to studying RNA molecules using nanotechnology and cryo-electron microscopy (cryo-EM), enabling the analysis of RNA subunits with unprecedented resolution. This breakthrough has significant implications for fundamental research, drug development, and RNA therapeutics.
Researchers at Northwestern University discovered a new mechanism called strand displacement, where RNA strands invade and displace each other to enable genetic expression. This finding has potential implications for designing successful drugs to target RNA-based diagnostics and treating illness and disease.
Researchers discovered RNA can bind two metabolites in a single pocket, regulating gene expression and potentially creating new antibacterial drugs. This finding provides more support for the 'RNA World' theory, which suggests RNA molecules enabled life to evolve 3.5 billion years ago.
A Northwestern University research team discovered similarities in RNA folding among riboswitches, which could impact the design of future RNA-specific therapeutics and synthetic biology tools. The findings could also inform efforts to treat diseases triggered by RNA-level misfolding.
Researchers at OIST and Osaka University develop an artificial cell system that interacts with histamine, a natural chemical compound. The system uses a riboswitch to turn on a gene inside the cells, which can eventually be used to release drugs in response to histamine signals.
Researchers deciphered the workings of a common bacterial switch that regulates protein production, revealing a snap-lock mechanism. This discovery could lead to new antibiotics as gram-positive bacteria use T-box riboswitches to regulate protein production.
Researchers analyzed the structure and dynamics of riboswitches using optical single-molecule experiments. They found that the riboswitch fluctuates between different conformations, with SAM attachment accelerating structure changes to ensure quick gene expression shutdown.
Researchers at UNC School of Medicine have developed a new imaging technique using nuclear magnetic resonance (NMR) to visualize RNA structure and motion over time. This discovery opens up new avenues for developing drugs that target RNA, crucial for understanding health and disease.
Researchers use X-ray laser to study RNA and biomolecules, gaining insights into fundamental cell workings and potential disease treatments. The study opens new paths to understanding how RNA regulates protein production and fine-tunes gene function.
Edward Nikonowicz will investigate a gene-regulating switch that could lead to the development of new antibiotics, targeting Bacillus anthracis bacteria.
Researchers at Ruhr-University Bochum successfully taught bacteria to swim by combining various RNA modules in a new way. The team used riboswitches and RNA thermometers to control the bacterium's behavior and responded to temperature and metabolic products.
Researchers at SISSA have identified a key mechanism by which riboswitches regulate gene expression in bacteria. By using computer simulations to model the dynamics of the process, they found that binding to a metabolite molecule stabilizes the active form of the riboswitch, triggering protein synthesis.
Researchers at Scripps Research Institute have discovered a genetic sequence that can alter its host gene's activity in response to cellular energy levels, a finding that could have broad implications for biology and medicine. The energy-sensing switch, known as a riboswitch, detects the molecule ATP and controls global metabolic regul...
Bacteria use riboswitches to detect and counteract the effects of fluoride, a key component of toothpaste. The discovery sheds light on how microbes overcome fluoride toxicity, potentially leading to new treatments for dental health issues.
New research reveals that many bacteria try to fend off fluoride by throwing it out, and that the presence of this transport system indicates fluoride has antimicrobial properties. The discovery also highlights a genetic switch called riboswitches, which can be used to enhance fluoride's effects against bacteria.
Scientists from Scripps Research Institute have discovered a new type of RNA molecule, called riboswitches, that can turn genes on or off in response to cellular energy needs. These findings may have implications for designing new antibiotics against harmful bacteria.
Max Planck scientists have successfully inserted a gene switch into the genetic material of chloroplasts in plant cells, allowing for controlled protein production. This breakthrough enables researchers to study the functions of chloroplasts and explore potential applications in biotechnology, such as producing antibiotics.
Researchers have achieved a breakthrough in regulating genes by hijacking riboswitches, opening doors for targeted drug discovery and synthetic biology. The study, published in Proceedings of the National Academy of Sciences, uses synthetic molecules to activate genes previously controlled by small naturally occurring molecules.
Researchers have identified a genetic mechanism in bacteria that could lead to the development of new antibiotics. The preQ1 riboswitch regulates gene expression by controlling the availability of queuosine, a molecule essential for bacterial survival and human disease.
Researchers at Stanford University used an optical trap to physically pull and fold a 3D RNA molecule, revealing the step-by-step formation of its tertiary structure. This breakthrough provides unprecedented insight into molecular folding behavior and opens doors for detailed studies of other molecules.
Researchers at Stanford University use an optical trap to physically manipulate RNA molecules, directly observing their three-dimensional folding for the first time. The study reveals the energy and folding behavior of a riboswitch, providing new insights into how biomolecules take shape and function.
Researchers created hairpin-shaped RNA molecules that can differentiate between riboswitches in on and off states. These aptamers could help find new antibiotics by binding to the switches of pathogens, blocking essential protein synthesis.
Researchers discovered a novel RNA-based sensor in Salmonella that responds to magnesium ions, allowing cells to assess and react to their environment. The discovery expands the types of molecules that can be detected by riboswitches.
Riboswitches are RNA elements that control gene expression in essential metabolic pathways. Researchers at Yale University have identified pyrithiamine as a toxic compound that disrupts these pathways, leading to the development of new antibiotics.
Researchers at Yale University have identified a cooperative RNA switch in nature, which responds to various target compounds and regulates metabolic processes. This discovery supports the theory of an RNA World, where RNA molecules served a central role in early life.