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Fewer laboratory animals thanks to secondary nanobodies

Researchers at the Max Planck Institute for Biophysical Chemistry have developed secondary nanobodies that outperform traditional antibodies in key cell-biological applications. These nanobodies can be produced in large scale by bacteria, reducing the need for animals in antibody production and improving resolution in light microscopy.

Bottle-brush design enhances cellular imaging

Researchers developed bottle-brush nanotags to enhance cellular imaging by containing thousands of fluorophores, overcoming the limit of self-quenching and amplifying signal detection. The design permits the use of different dyes, enabling a wide range of colors for these fluorescent nanotags.