Antibodies that mimic the SARS-CoV-2 virus may explain lingering symptoms of long-haul COVID-19 and rare vaccine side effects like allergic reactions and blood-clotting. This theory, based on classic immunological concepts, suggests a cascade of immune responses that can lead to adverse effects.
Researchers at the Max Planck Institute for Biophysical Chemistry have developed secondary nanobodies that outperform traditional antibodies in key cell-biological applications. These nanobodies can be produced in large scale by bacteria, reducing the need for animals in antibody production and improving resolution in light microscopy.
Researchers developed bottle-brush nanotags to enhance cellular imaging by containing thousands of fluorophores, overcoming the limit of self-quenching and amplifying signal detection. The design permits the use of different dyes, enabling a wide range of colors for these fluorescent nanotags.