Subcellular Distribution | Topics

Bulges calculated in the supercomputer: How cells digest their internal canal system

Researchers have discovered a mechanism to detach and recycle parts of cellular canal membranes as needed. The study, conducted with supercomputer simulations, shows that protein regions can cause the membrane to bulge and pinch off, forming vesicles for recycling.

SourceGoethe University Frankfurt·JournalProceedings of the National Academy of Sciences·TypeComputational simulation/modeling·DateNov 12, 2024

New neural framework enhances reconstruction of high-resolution images

A novel approach to overcome limitations of traditional methods, NeuPh uses local conditional neural fields to reconstruct high-resolution phase information from low-resolution measurements. It provides robust resolution enhancement and outperforms existing models in accuracy.

SourceSPIE--International Society for Optics and Photonics·JournalAdvanced Photonics Nexus·DateSep 5, 2024

Protein droplets likely don’t cause Parkinson’s

Researchers investigated the relationship between protein aggregation and liquid-liquid phase separation, finding that droplet formation may actually protect against aggregation. The study, led by Paul Scherrer Institute, used over 500 conditions to test the behavior of alpha-synuclein proteins.

SourcePaul Scherrer Institute·JournalAdvanced Science·TypeExperimental study·DateJul 15, 2024