Articles tagged with Thioredoxins
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Researchers have discovered that certain molecules inhibiting thioredoxin reductase (TrxR) have a more specific effect than gold-based therapy auranofin. TRi-1 and TRi-2 compounds show promise as anticancer drugs, with higher specificity in their inhibition of TrxR.
Researchers at MUSC discovered that thioredoxin, a powerful antioxidant molecule, can extend the life of adoptive T-cells and improve anti-tumor activity. This finding suggests that treating human T-cells with thioredoxin before administration may increase cell viability and improve the effectiveness of immune-based therapies.
Researchers have successfully resurrected a four-billion-year-old protein in modern E. coli bacteria, protecting it from viruses. This breakthrough could lead to the development of crop-resistant plants, as the ancient protein can't be hijacked by phages.
A University of Maryland research team identified a cell signaling pathway that contributes to developmental defects in babies of women with diabetes. The study suggests that reducing ASK1 activity may prevent these defects and proposes the use of a naturally occurring antioxidant, thioredoxin, as a potential therapeutic target.
Researchers found a compound called ebselen effectively inhibits the thioredoxin reductase system in Helicobacter pylori, which causes gastric ulcers, and Mycobacterium tuberculosis, which causes tuberculosis. Ebselen's mechanism targets bacteria lacking glutathione.
Scientists have discovered a new antibiotic principle that selectively blocks the thioredoxin system in bacterial cells, making certain bacteria vulnerable to inhibition. This mechanism could potentially treat conditions like stomach ulcers, TB, and MRSA, providing a new solution for combating antibiotic-resistant infections.
A study reveals that ancient enzymes known as thioredoxin were chemically stable at temperatures up to 32 degrees Celsius higher than their modern counterparts. The enzymes also showed increased activity at lower pH levels, indicating they operated in a hot, acidic environment during early life.
Scientists at the University of Leeds have identified a previously unknown natural mechanism that activates ion channels through thioredoxin, offering new opportunities for treating inflammatory diseases like rheumatoid arthritis. This breakthrough could lead to the development of innovative therapies.
A research team at the University of Michigan and the University of Texas describes how a resourceful bacterium developed an entirely new way to make disulfide bonds. This breakthrough could have significant implications for disease states like Alzheimer's and cystic fibrosis, as well as biotech applications.