Articles tagged with Transposase
Researchers developed a TnpB generation model to generate 100,000 mutant sequences of ISDra2 TnpB, selecting top five for experimental validation. The results showed high editing efficiencies at specific loci with the TnpB-TD mutant exhibiting stronger capabilities and diverse editing outcomes.
Researchers at EMBL developed a new variant of the Sleeping Beauty transposase with improved biochemical properties, allowing for direct protein delivery and autonomous cell penetration. This breakthrough enables efficient and stable genome modifications in target cells on demand.
Researchers identified five groups of PiggyBac transposases working together with PiggyMac to accurately delete specific pieces of DNA. This discovery sheds light on the mechanism of gene removal and its role in species development and evolution.
A team of scientists has identified a previously unknown mechanism that keeps transposable elements from causing harm by detaining them at the cell membrane. This discovery opens up new avenues for research on similar mechanisms in other organisms.