Articles tagged with Action Potential
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
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Scientists investigate whether living neurons can transport light through their axons, which would significantly change current models of the nervous system. If successful, it could have major implications for treating brain diseases and healing the brain.
Researchers at Thomas Jefferson University discovered a specific molecular change that affects the strength of pain sensation by altering action potential duration. This finding offers a novel approach to alleviate clinically relevant pain conditions through boosting potassium channel function.
Researchers propose a new model for understanding how information is transmitted in the brain by describing a unique axon morphology that changes size and modulates action potential speed
Researchers aim to shed light on how hearing impairment affects auditory perception, particularly in complex environments. They will use animal models to examine neural mechanisms contributing to difficulties in sound localization.
A team of scientists at Kanazawa University used high-speed atomic force microscopy to study the structural dynamics of sodium ion channels in cell membranes. They found that voltage sensor domains can dissociate from pore domains when the channel is in a resting state, leading to dimerization between neighboring channels. These findin...
A Venus flytrap mutant with a genetic defect has lost its ability to count prey touch numbers. Researchers analyzed gene expression patterns and calcium signaling pathways to understand the cause of the numerical disability.
Researchers developed an iEMG classifier framework for detecting myopathy and neuropathy, achieving high accuracy in three muscle types and low computational time. The study showed promise for real-time implementation, aiding clinicians in making quick and accurate diagnoses.
Researchers at OHSU have discovered a unique neural cell assembly that enables complex learning in songbirds, similar to those found in the human primary motor cortex. This finding has implications for understanding fine motor control and may lead to new avenues for treating disorders such as ALS.
Researchers developed a new system to measure and stimulate the entire ventricular surface of mouse hearts, allowing for simultaneous optical and electrical tracking of heart activity. The POEMS system provides accurate measurements of action potential propagation with minimal differences between modalities.
A multi-institutional team has identified a compound that prevents the lengthening of the heart's electrical event, preventing cardiac arrhythmia. The compound, C28, enhances the IKs potassium ion channel function without affecting normal action potentials.
A team of scientists has found that Venus flytrap electrical signals generate magnetic fields, detected using atomic magnetometers. The magnetic signals are weak, but comparable to human nerve impulse signals.
Researchers have isolated sensory hairs from the Venus flytrap and identified genes that convert mechanical stimuli into electrical signals. The discovery sheds light on how plants can detect and respond to touch, revolutionizing our understanding of plant biology.
Researchers discovered neurons adjust neurotransmitter release via signal tone modulation, enabling rapid communication. This mechanism allows neurons to fine-tune their 'voice' in real-time.
Researchers proposed an algorithm to create patient-specific models describing electrical excitation of human heart cells. The model uses gene expression profiles to predict action potential in other patients. This could lead to personalized treatment and drug design for heart conditions.
Researchers found that isoflurane weakens the transmission of electrical signals between neurons, particularly at higher frequency impulses. The anesthetic preferentially blocks these high frequency signals, while having minimal effect on low frequency impulses that control life-supporting functions.
Researchers have identified a link between abnormal calcium release and arrhythmias in heart failure, suggesting new therapies may improve early Ca2+ release. Restoration of AP phase 1 repolarization could mitigate defective excitation-contraction coupling and reduce sudden death risk.
Dendritic action potentials amplify human brain computational power, enabling single neurons to solve complex problems previously thought to require multi-layer neural networks. The investigation reveals a new class of dendritic calcium action potentials in L2/3 neurons.
Researchers have discovered two potassium channels, TREK-1 and TRAAK, at the Nodes of Ranvier that enable rapid sensory and motor reactions in mammals. The channels allow for high-frequency nerve impulses with speeds up to 200 meters per second, essential for survival in a predator-prey world.
Researchers at Johns Hopkins Medicine used mice to study decision-based memories, finding that they are stored in the prefrontal cortex. The study revealed that neurons in this region fire at a higher rate when making decisions, and that this rate slows down over time. This knowledge can help develop models of decision-making and poten...
Researchers discovered that the Venus flytrap's tactile sensors respond to minute pressure stimuli, converting them into electrical signals that cause the trap to close. The plant has evolved smaller traps to detect the smaller forces generated by lightweight mosquitoes.
Scientists have found spiking neurons in the tiny roundworm C. elegans, which could help understand fundamental principles of brain computation. The discovery overturns decades of dogma and reveals a unique coding mechanism that allows the worm's olfactory neurons to encode information in two ways.
A study by Columbia University researchers found that loss of Rbfox genes disrupts the assembly of the axon initial segment, crucial for neurons to fire action potentials. The team identified the Rbfox-controlled splicing of the Ankyrin-G gene as a key factor in this process.
A UTA researcher is working to determine how mechanical forces like blasts or repeated blows to the head can damage neurons and lead to neurological disorders. The goal is to create a computational model that can trace action potential inside neurons, potentially revealing the condition of brain's neurons.
Researchers found that a single docking site uses a single cluster of calcium channels and that both numbers change with brain age, establishing the first clear link between morphology and function of docking sites.
A study by Georgia Institute of Technology and FDA researchers found a new factor contributing to dangerous electrical turbulence in the heart, including varying amplitude of action potential. This discovery could lead to new methods for predicting and preventing life-threatening cardiac fibrillation.
Scientists have identified a mechanism that alters neural excitability, a key factor in diseases such as epilepsy, depression, and drug addiction. The discovery provides insight into these conditions and may offer a potential therapeutic target.
Researchers at Max Planck Florida Institute for Neuroscience developed novel approaches to study axonal excitability with unprecedented detail. They discovered that action potentials vary in shape depending on subcellular location and are influenced by potassium channel subtypes.
A team of Monell researchers used mice engineered with OMP knocked out to demonstrate that OMP filters 'noisy' signals, allowing accurate odor information to reach the brain. The findings increase understanding of how the olfactory system integrates and transmits data about odors.
Researchers found that axon initial segment (AIS) plasticity can occur quickly, influencing neuronal firing responses. After 3 hours of elevated activity, the AIS was shortened by approximately 25%, but did not immediately lead to reduced excitability.
A team of researchers has found that variations in the morphology of auditory axons, particularly the length of internodes and diameter, impact the speed and precision of signal transmission. This discovery challenges long-held assumptions about axon structure and function.
Researchers found that mutant sodium channels with opposite effects on channel function can lead to disruptions in normal cardiac function due to ion leaks. This overload of positively charged ions within the cell may be a key mechanism linking these mutations to atypical arrhythmias and dilated cardiomyopathy.
Researchers at OIST Graduate University found that extrasynaptic receptors are essential for establishing a plateau in the membrane potential of neurons, allowing them to signal more effectively. Blocking these receptors with memantine reduces the frequency and synchrony of neural activity.
Researchers analyzed 500 patients with diabetes mellitus and found altered nerve conduction in the early asymptomatic stage of diabetic peripheral neuropathy. The amplitude of sensory nerve action potential was the most sensitive measure of this condition, revealing varying degrees of nerve conduction changes.
The study found that a distance of 5 mm between recording and stimulating electrodes, and a distance of 10 mm between recording and stimulating sites, was optimal for compound nerve action potential recording. Additionally, orthodromic compound action potentials were more stable and displayed less interference than antidromic ones.
Basket cells convert excitatory signals into inhibitory outputs within milliseconds; researchers identify controlled increase in Na+ channels and conductance for fast transmission. Signal processing is made possible by high density of Na+ channels and increased conductance, compensating for small axon diameter and lack of myelination.
A team of researchers at ETH Zurich used high-resolution microelectrode arrays to measure axonal signal speed, finding significant variations within the same neuron. The study challenges the long-held assumption that axonal signal conduction is purely digital.
Researchers at the University of Bristol identified a novel cellular mechanism underlying age-related cognitive decline, revealing that changes to sodium channels contribute to decreased neuronal excitability. The study found that aged brain cells struggle to generate action potentials due to altered sodium channel activation properties.
Researchers have discovered that HCN channels, essential for the heart's electrical signals, are vital for normal repolarization. A new animal model showed a significant reduction in repolarization phase duration when one subtype of HCN channel protein was missing.
Researchers at the University of Bristol have received a major funding boost to continue their research into the pathological processes underpinning Alzheimer's disease. They have found that neuronal excitability is substantially altered in the model of Alzheimer's disease, leading to changes in action potential generation and waveform.
Researchers discovered that membrane potential-dependent modulation of recurrent inhibition is a key mechanism for maintaining dynamic balance of excitation and inhibition in the cortex. This finding has implications for understanding cortical rhythms and preventing abnormal cortical activities during seizures.
Researchers at Arizona State University have developed a new method of noninvasive brain stimulation using pulsed ultrasound, which stimulates action potentials and drives intact brain activity without surgery. The approach shows promise for diagnosing and treating brain dysfunctions such as epilepsy, Parkinson's disease, and depression.
Researchers successfully used a specialized fluorescent protein to visualize electrical activity in living mice, allowing them to study brain function and behavior in real-time. The 'cameleon' protein enables measurement of action potentials without electrodes, providing insights into neural networks and brain circuitry.
Scientists at Baylor College of Medicine discovered that adjacent neurons in the brain do not synchronize their action potentials, contrary to previous beliefs. This finding provides insight into how the brain processes information efficiently by introducing a 'decorrelated state' that allows for uncorrelated activity.
Researchers at the Max-Planck Institute for Brain Research found that brain cells can generate nerve impulses while being energy efficient. This discovery challenges previous estimates and has implications for understanding brain metabolism and non-invasive brain imaging techniques.
Researchers successfully optically detected individual action potentials in brain cells of mice, enabling observation of brain activity over months. This new method provides insights into neural communication and may aid in identifying early onset of neurological disorders like Alzheimer's and Parkinson's.
Researchers have developed a new system to improve hearing in patients with cochlear implants, analyzing Compound Action Potential records and voice processor programming. The study found that refractory periods decrease with auditory experience, reaching a stable value after 3-4 months.
A new mechanism of neuronal conduction of excitation has been discovered, independent of action potentials, using ceramide production. This finding opens up new perspectives for research and breaks away from the classic concept of neuronal functioning.
A study published in PLOS Computational Biology reveals that noise effects in ion channels are much larger than previously assumed, compromising the fidelity of neural transmission. The researchers used detailed models and simulations to demonstrate how channel noise destroys information in action potentials.
Researchers discovered a new mechanism in nerve cells that enables them to filter and transfer signals rapidly, contrary to the traditional Hodgkin-Huxley model. This allows for high precision in transmitting fast-changing signals while ignoring slowly varying stimuli.
Researchers have discovered that the brain uses a code more efficient than previously thought, with analog signals influencing synaptic transmission onto other neurons. This finding has significant implications for our basic understanding of brain operation and neuronal dysfunction.
The study reveals inhibitory systems play a crucial role in controlling the timing of action potentials and network synchronization. This fine-tuning affects cognitive functions and may underlie problems in psychiatric disorders like schizophrenia.
A new math model of heart cells has identified a novel calcium pathway that regulates cardiac electrical activity and is linked to arrhythmia research. The study, published in Circulation, provides a valuable tool for understanding the relationship between calcium handling and cardiac arrhythmias.
Biophysicists at Cornell University have developed a new technique to optically record millisecond-by-millisecond signaling through nerve cells. The method combines multiphoton microscopy with specially developed dyes and second-harmonic generation, allowing for high-resolution images of brain nerve impulses. This breakthrough could he...
Researchers at Rockefeller University have discovered the molecular mechanism by which potassium ions flow through living cells during a nerve or muscle impulse. The structure reveals four red-tipped paddles that open and close in response to positive and negative charges.