A molecule called Sindecam-4 (SDC4) on cell surfaces may help prevent tumor progression and metastasis. Silencing the receptor halted accelerated growth of tumor cells, causing them to resume responding to natural programmed cell death mechanisms.
SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalCytotechnology·DateJun 18, 2026
Researchers at Goethe University Frankfurt have discovered thalidomide derivatives that target and degrade BCL-2, a protein essential for the survival of cancer cells. The derivatives bind to CRBN, reprogramming its binding surface to mark BCL-2 for degradation, ultimately leading to cell death.
SourceGoethe University Frankfurt·JournalCell Reports Physical Science·TypeExperimental study·DateMay 13, 2024