The first oncogene was found more than 40 years ago. CNIO researchers have just discovered that it has a previously unknown mechanism of action
CNIO researchers have discovered a previously unknown mechanism of action for the first oncogene, c-Src. The study reveals that c-Src can autonomously activate itself through autophosphorylation, leading to cancer formation. This finding has significant implications for the development of new drugs targeting this enzyme.
SourceCentro Nacional de Investigaciones Oncológicas (CNIO)·JournalNature Communications·TypeExperimental study·DateOct 31, 2023