Articles tagged with Cytosol
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers used live fluorescence imaging experiments to uncover the mechanism behind cell volume regulation, revealing that WNK kinases activate the 'switch' through phase separation. This discovery has implications for human health, particularly in relation to kidney function and salt-sensitive hypertension.
The study assesses how temperature influences droplet size in elastic matrices, providing insights into biological molecule arrangement and condensate formation. It also explores the role of phase separation and its effect on droplet growth.
Divita Mathur is investigating cytosolic access and instability of DNA nanoparticles to overcome current delivery mechanisms. The goal is to create more biocompatible delivery systems, enabling advanced targeted therapies.
Researchers have unraveled the mechanisms of how cells capture and degrade fluid droplets through autophagy. The study reveals that a tug-of-war between the droplet's surface tension and the isolation membrane's bending energy governs this process, with the outcome determining whether a piece or complete droplet is captured.
Researchers identified a crown-shaped molecular pore in coronavirus replication compartments that may facilitate viral RNA export. This discovery offers a potential target for antiviral strategies against SARS-CoV-2 and other coronaviruses.
Researchers at Ludwig-Maximilians-Universität München identified a signaling pathway enabling mitochondria to transmit distress signals to the surrounding cytosol. This pathway involves enzymes OMA1 and DELE1, which trigger cellular responses to stress, potentially opening new therapeutic approaches for age-related diseases.
A study published in The Plant Journal has provided new insights into the dynamics of metabolic processes in eukaryotic cells. By quantifying the subcellular distribution of proteins and metabolites, researchers have identified key regulatory mechanisms controlling plant metabolism.
Researchers at ETH Zurich have developed a new method for extracting the content of single living cells, enabling scientists to study individual cells at the molecular level. The technique allows for precise extraction of intracellular material, preserving live cells for repeated sampling and analysis.
The International Classification of Functioning, Disability and Health (ICF) provides a scientific basis for understanding health and disability states. ICF has become a valuable tool to increase communication among different users in clinical practice and research.
A new theoretical model shows that the length of microtubules is regulated by the attachment of motor proteins, which grow towards the plus-end and shorten the filament. This interplay between growth and shrinkage maintains a precisely regulated microtubule length essential for various intracellular tasks.
The DALYs system, widely used to measure public health interventions' effects, fails to account for the complexities of disability. Critics argue that this approach undervalues the lives of disabled individuals, instead prioritizing those without disabilities.
A study found a higher prevalence of the D variant in the ACE gene among Gulf War veterans with chronic fatigue syndrome. Veterans with specific genetic variants were more likely to develop CFS/ICF, suggesting an interaction between genetics and environmental factors related to deployment.
Researchers found that bacterial proteins are destroyed by the proteasome within the cytosol during infection, activating the immune system. Bacteria like Listeria avoid recognition by moving within the cytosol, preventing immune activation.
A new theory explains how prion diseases get started and kill neurons by showing that small amounts of misfolded PrP in the cytosol can cause cell death. The research also reveals a mechanism for the conversion of normal PrP to its toxic form, which can then spread and aggregate.