Researchers discovered multiple molecular subtypes of kinesin-2 with distinct compositions and functions, including a KIF3B/B/KAP3 complex that preferentially associates with TRIM46 and facilitates its transport to the AIS. This study provides insights into how neurons regulate cargo delivery with specificity.
SourceJuntendo University Research Promotion Center·JournalJournal of Cell Biology·TypeExperimental study·DateApr 10, 2026
For the first time, researchers have directly visualized how newly formed cellular organelles leave the endoplasmic reticulum and transition onto microtubule tracks inside living cells. The study reveals that the ER plays an active role in steering intracellular traffic.
SourceInstitute for Basic Science·JournalACS Nano·TypeExperimental study·DateJan 28, 2026
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Researchers uncover a unique structural motif in the tail region of kinesin-2 that acts as a molecular 'connector,' allowing the motor to correctly recognize and transport its cargo inside cells. The discovery provides new insights into brain transport and diseases, paving the way for diagnostic and therapeutic approaches.
SourceJuntendo University Research Promotion Center·JournalScience Advances·TypeExperimental study·DateNov 6, 2025
Researchers at Osaka Metropolitan University have discovered a key protein involved in transporting boron into plant cells. The protein complex, containing KNS3 and its homologs, facilitates the movement of boric acid channels from endoplasmic reticulum to plasma membrane.
SourceOsaka Metropolitan University·JournalJournal of Experimental Botany·TypeExperimental study·DateOct 29, 2024
Live imaging techniques reveal that the secretory pathway plays a crucial role in de novo membrane formation, with Gip1 identified as a key molecule affecting this process. In Gip1-deficient cells, abnormal spore plasma membranes are formed due to defects in regenerating ER exit sites.
SourceUniversity of Tsukuba·JournaliScience·DateSep 27, 2024
The study reveals two distinct modes of endosomal fusion: homotypic fusion, where small vesicles fuse rapidly, and heterotypic fusion, where large vesicles absorb endosomes. Mathematical analysis and experiments suggest that actin dynamics plays a crucial role in promoting homotypic fusion.
SourceUniversity of Tsukuba·JournaleLife·DateApr 8, 2024
Researchers developed temporal compressive super-resolution microscopy (TCSRM) to overcome optical diffraction's spatial resolution restriction. TCSRM achieves high-speed imaging at 1200 frames per second with a spatial resolution of 100 nanometers, enabling observation of fast dynamics in fine structures.
SourceSPIE--International Society for Optics and Photonics·JournalAdvanced Photonics·DateMar 10, 2023
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Scientists have elucidated the regulatory functions of Pan1p, a key player in late-stage clathrin-mediated endocytosis. The protein drives actin assembly and disassembly, facilitating vesicle internalization.
SourceTokyo University of Science·JournalJournal of Cell Biology·TypeExperimental study·DateAug 24, 2022
Researchers developed a mathematical model to predict the efficiency of nanoparticle delivery into cells, particularly in stem cells. They found that nanoparticles become trapped in bubble-like vesicles, preventing them from reaching their targets.
SourceXi'an Jiaotong-Liverpool University·JournalACS Nano·TypeExperimental study·DateJul 20, 2022
Scientists at the University of Münster and Max Planck Institute have clarified the molecular basis for cellular degradation processes by elucidating the 3D structure of Mon1/Ccz1. The complex determines which vesicles deliver their content to the lysosome, a key step in protein regulation.
SourceUniversity of Münster·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateFeb 2, 2022
A research team led by Associate Professor Akira Kakugo of Hokkaido University has provided direct evidence that microtubules function as mechanosensors, slowing down kinesin movement when bent. This phenomenon is attributed to enhanced interaction energy between kinesin and deformed microtubule structural units.
SourceHokkaido University·JournalScience Advances·TypeExperimental study·DateOct 13, 2021
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The Biophysical Society has named eight award recipients for their groundbreaking work in biophysics. The winners include Tom Rapoport, James Hamilton, and S. Walter Englander, who will receive prestigious awards for their contributions to fields such as protein transport, lipid biology, and single molecule biology.