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Composition of neuronal motor proteins regulates their cargo-specificity

Researchers discovered multiple molecular subtypes of kinesin-2 with distinct compositions and functions, including a KIF3B/B/KAP3 complex that preferentially associates with TRIM46 and facilitates its transport to the AIS. This study provides insights into how neurons regulate cargo delivery with specificity.

SourceJuntendo University Research Promotion Center·JournalJournal of Cell Biology·TypeExperimental study·DateApr 10, 2026

Capturing the moment of organelle handoff inside living cells

For the first time, researchers have directly visualized how newly formed cellular organelles leave the endoplasmic reticulum and transition onto microtubule tracks inside living cells. The study reveals that the ER plays an active role in steering intracellular traffic.

SourceInstitute for Basic Science·JournalACS Nano·TypeExperimental study·DateJan 28, 2026
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Newly discovered ‘hook’ in motor protein reveals how neurons deliver cargo with precision

Researchers uncover a unique structural motif in the tail region of kinesin-2 that acts as a molecular 'connector,' allowing the motor to correctly recognize and transport its cargo inside cells. The discovery provides new insights into brain transport and diseases, paving the way for diagnostic and therapeutic approaches.

SourceJuntendo University Research Promotion Center·JournalScience Advances·TypeExperimental study·DateNov 6, 2025

Spirited away: Key protein aids transport within plant cells

Researchers at Osaka Metropolitan University have discovered a key protein involved in transporting boron into plant cells. The protein complex, containing KNS3 and its homologs, facilitates the movement of boric acid channels from endoplasmic reticulum to plasma membrane.

SourceOsaka Metropolitan University·JournalJournal of Experimental Botany·TypeExperimental study·DateOct 29, 2024
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High-speed super-resolution microscopy via temporal compression

Researchers developed temporal compressive super-resolution microscopy (TCSRM) to overcome optical diffraction's spatial resolution restriction. TCSRM achieves high-speed imaging at 1200 frames per second with a spatial resolution of 100 nanometers, enabling observation of fast dynamics in fine structures.

SourceSPIE--International Society for Optics and Photonics·JournalAdvanced Photonics·DateMar 10, 2023
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First 3D structure of regulator protein revealed

Scientists at the University of Münster and Max Planck Institute have clarified the molecular basis for cellular degradation processes by elucidating the 3D structure of Mon1/Ccz1. The complex determines which vesicles deliver their content to the lysosome, a key step in protein regulation.

SourceUniversity of Münster·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateFeb 2, 2022

First evidence of microtubules’ mechanosensitive behavior

A research team led by Associate Professor Akira Kakugo of Hokkaido University has provided direct evidence that microtubules function as mechanosensors, slowing down kinesin movement when bent. This phenomenon is attributed to enhanced interaction energy between kinesin and deformed microtubule structural units.

SourceHokkaido University·JournalScience Advances·TypeExperimental study·DateOct 13, 2021

Biophysical Society names 2010 award recipients

The Biophysical Society has named eight award recipients for their groundbreaking work in biophysics. The winners include Tom Rapoport, James Hamilton, and S. Walter Englander, who will receive prestigious awards for their contributions to fields such as protein transport, lipid biology, and single molecule biology.

SourceBiophysical Society·DateSep 4, 2009