Add BrightSurf on Google Email

Programmed cell death in cancer cells: Overcoming resistance through paraptosis-inducing compounds

Researchers from Tokyo University of Science developed novel complex-peptide hybrids that induce programmed cell death in apoptosis-resistant cancer cells through paraptosis. The compounds, syn-6 and anti-6, inhibit cell death by uncoupling mitochondrial calcium uptake and inducing cytoplasmic vacuolization, leading to cell death.

SourceTokyo University of Science·JournalBioconjugate Chemistry·TypeExperimental study·DateJul 11, 2022