Articles tagged with M Cells
Researchers have identified a new immune function of human M cells, which can process and present gluten antigens, suggesting a potential link to celiac disease. This discovery sheds light on gut immunity and may support future research into celiac disease diagnosis or treatment.
Researchers at UC Riverside have discovered a new cell type in the thymus that is similar to M cells found in the gut and airways. The newly discovered cells are like gatekeepers, acting as antigen-delivery cells for the immune system in organs such as the intestine and lung.
The study found that a combination of NOX1, loss of function, and TNF leads to an abnormal increase in microfold cells, driving increased recruitment of immune cells. Reversing the defect with reactive oxygen species restored healthy gut balance. Further studies on reactive oxygen species-stem cell modulation therapy are proposed.
A joint team from Hokkaido University and Keio University has identified a key player in the gut defense mechanism of infants, a protein called Sox8. This discovery could help understand how infants develop their own intestinal immune systems after weaning.
A team of biomedical scientists at UC Riverside has identified a specific receptor, TNFR2, that induces M cells, which promote inflammation and worsen IBD. Targeting only this receptor may lead to more effective therapies for IBD patients.
Researchers found that prion diseases can infect the gut through contaminated meat, and that M cells are key to whether or not the infection takes hold. The study suggests that factors like inflammation and ageing may influence a person's risk of contracting prion diseases.
Research found that TNF-alpha induces immune surveillance cells called M cells, which promote the body's ability to regulate and suppress inflammatory responses. This discovery could lead to more targeted drug therapies for treating IBD and other autoimmune diseases.
Scientists discovered that enterocytes play a significant role in absorbing relatively large particles, challenging conventional wisdom and offering new avenues for increasing the absorption of medicines taken by mouth. The study found that between 10-50% of spheres were absorbed via endocytosis in cells called enterocytes.
Researchers have identified a master regulator gene, Spi-B, essential for the development of M cells, which play a crucial role in initiating immune responses. This discovery could aid research on oral vaccines and inflammatory bowel diseases by providing valuable insights into M cell differentiation and function.